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Identification
HMDB Protein ID HMDBP03116
Secondary Accession Numbers
  • 8658
  • HMDBP05693
Name Phosphopantothenoylcysteine decarboxylase
Synonyms
  1. CoaC
  2. PPC-DC
Gene Name PPCDC
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Necessary for the biosynthesis of coenzyme A. Catalyzes the decarboxylation of 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
Pathways
  • coenzyme A biosynthesis
  • Pantothenate and CoA biosynthesis
  • Pantothenate and CoA Biosynthesis
Reactions
N-((R)-4'-phosphopantothenoyl)-L-cysteine → Pantetheine 4'-phosphate + CO(2) details
4'-Phosphopantothenoylcysteine → Pantetheine 4'-phosphate + Carbon dioxide details
GO Classification
Biological Process
pantothenate metabolic process
coenzyme A biosynthetic process
coenzyme biosynthetic process
Cellular Component
cytosol
Function
catalytic activity
Molecular Function
phosphopantothenoylcysteine decarboxylase activity
Cellular Location Not Available
Gene Properties
Chromosome Location 15
Locus 15q24.2
SNPs PPCDC
Gene Sequence
>615 bp
ATGGAACCAAAGGCCTCCTGTCCAGCTGCTGCACCCTTGATGGAGAGAAAATTCCATGTT
CTTGTGGGTGTCACGGGGAGTGTCGCAGCCCTGAAGTTGCCTCTTCTGGTGTCAAAGCTT
TTGGACATTCCTGGGCTGGAAGTAGCAGTGGTCACAACTGAGAGAGCCAAACATTTCTAC
AGCCCCCAGGACATTCCTGTCACCCTCTACAGCGACGCTGATGAATGGGAGATATGGAAG
AGCCGCTCTGACCCAGTTCTGCACATTGACCTGCGGAGGTGGGCAGACCTCCTGCTGGTG
GCTCCTCTTGATGCCAACACTCTGGGGAAGGTGGCCAGTGGCATCTGTGACAACTTGCTT
ACCTGCGTCATGCGGGCCTGGGACCGCAGCAAGCCCCTGCTCTTCTGCCCGGCCATGAAC
ACCGCCATGTGGGAGCACCCGATCACAGCGCAGCAGGTAGACCAGCTCAAGGCCTTTGGC
TATGTCGAGATCCCCTGTGTGGCCAAGAAGCTGGTGTGCGGAGATGAAGGTCTCGGGGCC
ATGGCTGAAGTGGGGACCATCGTGGACAAAGTGAAAGAAGTCCTCTTCCAGCACAGTGGC
TTCCAGCAGAGTTGA
Protein Properties
Number of Residues 204
Molecular Weight 22394.965
Theoretical pI 6.102
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphopantothenoylcysteine decarboxylase
MEPKASCPAAAPLMERKFHVLVGVTGSVAALKLPLLVSKLLDIPGLEVAVVTTERAKHFY
SPQDIPVTLYSDADEWEIWKSRSDPVLHIDLRRWADLLLVAPLDANTLGKVASGICDNLL
TCVMRAWDRSKPLLFCPAMNTAMWEHPITAQQVDQLKAFGYVEIPCVAKKLVCGDEGLGA
MAEVGTIVDKVKEVLFQHSGFQQS
GenBank ID Protein 71725351
UniProtKB/Swiss-Prot ID Q96CD2
UniProtKB/Swiss-Prot Entry Name COAC_HUMAN
PDB IDs
GenBank Gene ID NM_021823.3
GeneCard ID PPCDC
GenAtlas ID PPCDC
HGNC ID HGNC:28107
References
General References
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  3. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res. 2003 Oct;13(10):2265-70. Epub 2003 Sep 15. [PubMed:12975309 ]
  4. Zody MC, Garber M, Sharpe T, Young SK, Rowen L, O'Neill K, Whittaker CA, Kamal M, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Kodira CD, Madan A, Qin S, Yang X, Abbasi N, Abouelleil A, Arachchi HM, Baradarani L, Birditt B, Bloom S, Bloom T, Borowsky ML, Burke J, Butler J, Cook A, DeArellano K, DeCaprio D, Dorris L 3rd, Dors M, Eichler EE, Engels R, Fahey J, Fleetwood P, Friedman C, Gearin G, Hall JL, Hensley G, Johnson E, Jones C, Kamat A, Kaur A, Locke DP, Madan A, Munson G, Jaffe DB, Lui A, Macdonald P, Mauceli E, Naylor JW, Nesbitt R, Nicol R, O'Leary SB, Ratcliffe A, Rounsley S, She X, Sneddon KM, Stewart S, Sougnez C, Stone SM, Topham K, Vincent D, Wang S, Zimmer AR, Birren BW, Hood L, Lander ES, Nusbaum C: Analysis of the DNA sequence and duplication history of human chromosome 15. Nature. 2006 Mar 30;440(7084):671-5. [PubMed:16572171 ]
  5. Daugherty M, Polanuyer B, Farrell M, Scholle M, Lykidis A, de Crecy-Lagard V, Osterman A: Complete reconstitution of the human coenzyme A biosynthetic pathway via comparative genomics. J Biol Chem. 2002 Jun 14;277(24):21431-9. Epub 2002 Mar 28. [PubMed:11923312 ]
  6. Strauss E, Zhai H, Brand LA, McLafferty FW, Begley TP: Mechanistic studies on phosphopantothenoylcysteine decarboxylase: trapping of an enethiolate intermediate with a mechanism-based inactivating agent. Biochemistry. 2004 Dec 14;43(49):15520-33. [PubMed:15581364 ]
  7. Manoj N, Ealick SE: Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase. Acta Crystallogr D Biol Crystallogr. 2003 Oct;59(Pt 10):1762-6. Epub 2003 Sep 19. [PubMed:14501115 ]