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Identification
HMDB Protein ID HMDBP03256
Secondary Accession Numbers
  • 8829
Name Sodium-dependent phosphate transport protein 1
Synonyms
  1. Na(+)/PI cotransporter 1
  2. Na/Pi-4
  3. Renal Na(+)-dependent phosphate cotransporter 1
  4. Renal sodium-dependent phosphate transport protein 1
  5. Renal sodium-phosphate transport protein 1
  6. Sodium/phosphate cotransporter 1
  7. Solute carrier family 17 member 1
Gene Name SLC17A1
Protein Type Unknown
Biological Properties
General Function Involved in transmembrane transport
Specific Function Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
urate metabolic process
sodium ion transport
Cellular Component
integral to plasma membrane
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
inorganic anion transmembrane transporter activity
phosphate transmembrane transporter activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
anion transmembrane transporter activity
Molecular Function
symporter activity
sodium-dependent phosphate transmembrane transporter activity
Process
establishment of localization
transport
phosphate transport
transmembrane transport
anion transport
inorganic anion transport
ion transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location 6
Locus 6p22.2
SNPs SLC17A1
Gene Sequence
>1404 bp
ATGCAAATGGATAACCGGTTGCCTCCCAAAAAAGTTCCAGGTTTCTGTTCCTTTCGCTAT
GGATTGTCTTTCCTTGTGCACTGTTGTAATGTTATAATAACAGCACAGCGTGCGTGCCTG
AACCTCACAATGGTAGTCATGGTGAATAGCACAGATCCACATGGTTTGCCCAACACCTCC
ACAAAGAAGCTCCTGGATAATATAAAGAACCCTATGTATAATTGGAGCCCAGATATCCAG
GGAATCATCTTGAGTTCCACCTCCTATGGTGTCATCATCATCCAAGTTCCTGTTGGATAC
TTCTCTGGAATATATTCTACAAAGAAAATGATTGGCTTTGCATTATGCCTCAGCTCTGTG
TTAAGCCTGCTCATCCCACCAGCAGCTGGAATTGGAGTAGCTTGGGTCGTTGTATGTCGA
GCAGTTCAGGGAGCAGCCCAGGGGATAGTTGCAACAGCCCAGTTTGAAATATATGTCAAA
TGGGCTCCTCCCCTGGAACGAGGCCGACTTACTTCTATGAGTACATCAGGGTTTTTGCTG
GGACCCTTTATTGTCCTACTTGTGACTGGAGTTATCTGTGAATCTCTGGGCTGGCCCATG
GTCTTCTATATTTTTGGTGCTTGTGGCTGTGCCGTATGTCTTCTCTGGTTCGTTCTGTTT
TATGATGACCCCAAAGACCACCCATGTATAAGCATCAGTGAAAAGGAATACATCACATCC
TCCCTGGTCCAGCAGGTCAGTTCAAGTAGACAATCTCTGCCTATCAAGGCTATACTTAAG
TCGCTTCCAGTCTGGGCTATTTCCACTGGTAGTTTTACGTTTTTCTGGTCACATAACATC
ATGACACTATACACTCCAATGTTTATCAACTCCATGCTTCATGTTAATATAAAAGAGAAT
GGGTTCTTGTCTTCCCTTCCCTATTTGTTTGCCTGGATCTGTGGTAACCTAGCAGGTCAG
TTATCAGACTTCTTCCTGACCAGGAATATTCTCAGCGTAATTGCTGTCCGGAAACTCTTC
ACAGCAGCAGGATTTCTCCTTCCTGCAATCTTTGGTGTCTGCCTGCCTTACCTGAGTTCC
ACCTTCTACAGCATTGTCATTTTCCTAATACTTGCTGGTGCAACAGGCAGCTTTTGCTTG
GGTGGAGTGTTTATAAATGGCTTGGATATTGCTCCCAGATATTTTGGATTTATTAAAGCA
TGTTCAACTTTAACTGGAATGATAGGAGGACTAATTGCTTCCACTTTGACTGGATTGATC
CTTAAGCAGGATCCGGAATCCGCCTGGTTTAAAACCTTCATCCTGATGGCAGCCATTAAT
GTGACTGGCCTAATTTTCTACCTTATAGTTGCTACAGCAGAAATTCAGGACTGGGCTAAA
GAAAAACAACACACACGTCTCTGA
Protein Properties
Number of Residues 467
Molecular Weight 51131.04
Theoretical pI 8.565
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Sodium-dependent phosphate transport protein 1
MQMDNRLPPKKVPGFCSFRYGLSFLVHCCNVIITAQRACLNLTMVVMVNSTDPHGLPNTS
TKKLLDNIKNPMYNWSPDIQGIILSSTSYGVIIIQVPVGYFSGIYSTKKMIGFALCLSSV
LSLLIPPAAGIGVAWVVVCRAVQGAAQGIVATAQFEIYVKWAPPLERGRLTSMSTSGFLL
GPFIVLLVTGVICESLGWPMVFYIFGACGCAVCLLWFVLFYDDPKDHPCISISEKEYITS
SLVQQVSSSRQSLPIKAILKSLPVWAISTGSFTFFWSHNIMTLYTPMFINSMLHVNIKEN
GFLSSLPYLFAWICGNLAGQLSDFFLTRNILSVIAVRKLFTAAGFLLPAIFGVCLPYLSS
TFYSIVIFLILAGATGSFCLGGVFINGLDIAPRYFGFIKACSTLTGMIGGLIASTLTGLI
LKQDPESAWFKTFILMAAINVTGLIFYLIVATAEIQDWAKEKQHTRL
GenBank ID Protein 154800443
UniProtKB/Swiss-Prot ID Q14916
UniProtKB/Swiss-Prot Entry Name NPT1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005074.3
GeneCard ID SLC17A1
GenAtlas ID SLC17A1
HGNC ID HGNC:10929
References
General References
  1. Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S: The DNA sequence and analysis of human chromosome 6. Nature. 2003 Oct 23;425(6960):805-11. [PubMed:14574404 ]
  2. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  3. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  4. Chong SS, Kristjansson K, Zoghbi HY, Hughes MR: Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. Genomics. 1993 Nov;18(2):355-9. [PubMed:8288239 ]
  5. Soumounou Y, Gauthier C, Tenenhouse HS: Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity. Am J Physiol Renal Physiol. 2001 Dec;281(6):F1082-91. [PubMed:11704559 ]
  6. Taketani Y, Miyamoto K, Chikamori M, Tanaka K, Yamamoto H, Tatsumi S, Morita K, Takeda E: Characterization of the 5' flanking region of the human NPT-1 Na+/phosphate cotransporter gene. Biochim Biophys Acta. 1998 Mar 13;1396(3):267-72. [PubMed:9545579 ]
  7. Miyamoto K, Tatsumi S, Sonoda T, Yamamoto H, Minami H, Taketani Y, Takeda E: Cloning and functional expression of a Na(+)-dependent phosphate co-transporter from human kidney: cDNA cloning and functional expression. Biochem J. 1995 Jan 1;305 ( Pt 1):81-5. [PubMed:7826357 ]