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Identification
HMDB Protein ID HMDBP03881
Secondary Accession Numbers
  • 9469
Name Lengsin
Synonyms
  1. Glutamate-ammonia ligase domain-containing protein 1
  2. Lens glutamine synthase-like
Gene Name LGSN
Protein Type Enzyme
Biological Properties
General Function Involved in glutamate-ammonia ligase activity
Specific Function May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity
Pathways Not Available
Reactions Not Available
GO Classification
Function
catalytic activity
ligase activity
acid-ammonia (or amide) ligase activity
ammonia ligase activity
glutamate-ammonia ligase activity
ligase activity, forming carbon-nitrogen bonds
Process
metabolic process
nitrogen compound metabolic process
cellular metabolic process
glutamine metabolic process
glutamine family amino acid metabolic process
glutamine biosynthetic process
cellular amino acid and derivative metabolic process
cellular amino acid metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:6
Locus 6pter-q22.33
SNPs LGSN
Gene Sequence
>1530 bp
ATGAATAATGAAGAGGACCTTCTGCAGGAGGACTCAACAAGAGATGAAGGCAATGAGACT
GAAGCCAACAGCATGAACACATTAAGAAGGACAAGGAAGAAAGTCACTAAACCATATGTT
TGTTCAACTGAAGTGGGAGAAACGGATATGTCCAATTCAAATGATTGCATGAGGGACAGC
AGTCAAATTTTGACCCCACCTCAACTCTCTTCTAGAATGAAACACATTAGACAAGCCATG
GCCAAAAATCGCCTCCAGTTTGTACGATTTGAAGCAACAGACCTCCACGGCGTGTCCAGG
TCTAAGACTATCCCTGCACACTTTTTTCAAGAGAAAGTGAGCCATGGTGTTTGCATGCCC
CGAGGTTATCTTGAAGTGATACCAAATCCAAAGGACAATGAAATGAATAACATAAGAGCC
ACATGTTTTAATAGCGACATAGTCCTAATGCCAGAGTTATCAACCTTTAGAGTTTTGCCA
TGGGCTGACAGAACTGCAAGAGTGATATGTGATACCTTCACTGTGACTGGTGAGCCTCTT
TTGACTTCCCCAAGGTACATTGCAAAGAGGCAGCTGAGCCATCTGCAGGCCTCTGGCTTT
TCCCTGCTTTCTGCTTTCATCTATGATTTTTGCATTTTTGGTGTGCCCGAAATTTTAAAT
TCAAAGATTATATCTTTTCCTGCTTTAACATTTTTAAATAACCATGATCAGCCCTTCATG
CAGGAACTTGTTGATGGCTTGTATCACACTGGAGCCAATGTCGAGAGTTTTTCCTCCTCT
ACCAGGCCTGGTCAGATGGAAATCTCTTTCCTGCCTGAATTTGGCATTAGCTCAGCTGAT
AATGCATTTACCCTCAGAACAGGTGTCAAAGAAGTGGCAAGGAAATATAATTACATTGCC
AGCTTCTTCATTGAGACTGGATTTTGTGATTCAGGGATTTTGTCTCATAGTCTCTGGGAT
GTCGATAGGAAGAAAAACATGTTCTGCAGCACTTCTGGAACTGAGCAGCTCACGATCACT
GGGAAAAAATGGTTGGCAGGACTCTTGAAGCACTCTGCTGCGCTCAGCTGCCTGATGGCG
CCTTCTGTTAGCTGCCGAAAGCGTTATTCCAAGGACAGGAAAGACCTGAAGAAGAGTGTG
CCTACAACATGGGGATACAATGACAACAGCTGTATATTTAATATCAAATGTCATGGAGAG
AAAGGCACCCGGATAGAAAATAAACTAGGCTCAGCAACAGCAAACCCTTACTTGGTGCTG
GCTGCAACTGTTGCTGCCGGCTTAGATGGACTTCATAGCAGTAATGAGGTCTTGGCTGGT
CCAGATGAGAGCACAGACTTTTACCAAGTGGAACCTTCTGAGATCCCTTTAAAACTAGAA
GATGCCCTTGTGGCACTGGAAGAAGATCAATGCCAGAGACAGGCTCTAGGAGAAACCTTT
ATTCGATATTTTGTTGCCATGAAGAAATATGAGTTGGAGAATGAAGAAATAGCTGCAGAG
AGAAATAAATTCTTAGAGTATTTTATTTAG
Protein Properties
Number of Residues 509
Molecular Weight 57277.5
Theoretical pI 6.3
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Lengsin
MNNEEDLLQEDSTRDEGNETEANSMNTLRRTRKKVTKPYVCSTEVGETDMSNSNDCMRDS
SQILTPPQLSSRMKHIRQAMAKNRLQFVRFEATDLHGVSRSKTIPAHFFQEKVSHGVCMP
RGYLEVIPNPKDNEMNNIRATCFNSDIVLMPELSTFRVLPWADRTARVICDTFTVTGEPL
LTSPRYIAKRQLSHLQASGFSLLSAFIYDFCIFGVPEILNSKIISFPALTFLNNHDQPFM
QELVDGLYHTGANVESFSSSTRPGQMEISFLPEFGISSADNAFTLRTGVKEVARKYNYIA
SFFIETGFCDSGILSHSLWDVDRKKNMFCSTSGTEQLTITGKKWLAGLLKHSAALSCLMA
PSVSCRKRYSKDRKDLKKSVPTTWGYNDNSCIFNIKCHGEKGTRIENKLGSATANPYLVL
AATVAAGLDGLHSSNEVLAGPDESTDFYQVEPSEIPLKLEDALVALEEDQCLRQALGETF
IRYFVAMKKYELENEEIAAERNKFLEYFI
GenBank ID Protein 7341339
UniProtKB/Swiss-Prot ID Q5TDP6
UniProtKB/Swiss-Prot Entry Name LGSN_HUMAN
PDB IDs Not Available
GenBank Gene ID AF242388
GeneCard ID LGSN
GenAtlas ID LGSN
HGNC ID HGNC:21016
References
General References
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  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Grassi F, Moretto N, Rivetti C, Cellai S, Betti M, Marquez AJ, Maraini G, Ottonello S: Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens. Biochem Biophys Res Commun. 2006 Nov 17;350(2):424-9. Epub 2006 Sep 25. [PubMed:17010935 ]
  4. Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K: Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Mol Vis. 2002 Jun 15;8:171-84. [PubMed:12107413 ]