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Identification
HMDB Protein ID HMDBP04072
Secondary Accession Numbers
  • 9661
Name Adenylate kinase 2, mitochondrial
Synonyms
  1. AK 2
  2. ATP-AMP transphosphorylase 2
Gene Name AK2
Protein Type Enzyme
Biological Properties
General Function Involved in ATP binding
Specific Function Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.
Pathways
  • Adefovir Dipivoxil Metabolism Pathway
  • Purine metabolism
  • Tenofovir Metabolism Pathway
Reactions
Adenosine triphosphate + Adenosine monophosphate → ADP details
Adenosine triphosphate + Deoxyadenosine monophosphate → ADP + dADP details
GO Classification
Biological Process
nucleobase-containing small molecule interconversion
Cellular Component
mitochondrial inner membrane
mitochondrial intermembrane space
Function
binding
catalytic activity
nucleotide kinase activity
phosphotransferase activity, phosphate group as acceptor
transferase activity
adenylate kinase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
nucleobase, nucleoside, nucleotide kinase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
Molecular Function
ATP binding
adenylate kinase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Cellular Location
  1. Mitochondrion intermembrane space
Gene Properties
Chromosome Location 1
Locus 1p34
SNPs AK2
Gene Sequence
>720 bp
ATGGCTCCCAGCGTGCCAGCGGCAGAACCCGAGTATCCTAAAGGCATCCGGGCCGTGCTG
CTGGGGCCTCCCGGGGCCGGTAAAGGGACCCAGGCACCCAGATTGGCTGAAAACTTCTGT
GTCTGCCATTTAGCTACTGGGGACATGCTGAGGGCCATGGTGGCTTCTGGCTCAGAGCTA
GGAAAAAAGCTGAAGGCAACTATGGATGCTGGGAAACTGGTGAGTGATGAAATGGTAGTG
GAGCTCATTGAGAAGAATTTGGAGACCCCCTTGTGCAAAAATGGTTTTCTTCTGGATGGC
TTCCCTCGGACTGTGAGGCAGGCAGAAATGCTCGATGACCTCATGGAGAAGAGGAAAGAG
AAGCTTGATTCTGTGATTGAATTCAGCATCCCAGACTCTCTGCTGATCCGAAGAATCACA
GGAAGGCTGATTCACCCCAAGAGTGGCCGTTCCTACCACGAGGAGTTCAACCCTCCAAAA
GAGCCCATGAAAGATGACATCACCGGGGAACCCTTGATCCGTCGATCAGATGATAATGAA
AAGGCCTTGAAAATCCGCCTGCAAGCCTACCACACTCAAACCACCCCACTCATAGAGTAC
TACAGGAAACGGGGGATCCACTCCGCCATCGATGCATCCCAGACCCCCGATGTCGTGTTC
GCAAGCATCCTAGCAGCCTTCTCCAAAGCCACATGTAAAGACTTGGTTATGTTTATCTAA
Protein Properties
Number of Residues 239
Molecular Weight 24648.125
Theoretical pI 6.696
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Adenylate kinase 2, mitochondrial
MAPSVPAAEPEYPKGIRAVLLGPPGAGKGTQAPRLAENFCVCHLATGDMLRAMVASGSEL
GKKLKATMDAGKLVSDEMVVELIEKNLETPLCKNGFLLDGFPRTVRQAEMLDDLMEKRKE
KLDSVIEFSIPDSLLIRRITGRLIHPKSGRSYHEEFNPPKEPMKDDITGEPLIRRSDDNE
KALKIRLQAYHTQTTPLIEYYRKRGIHSAIDASQTPDVVFASILAAFSKATCKDLVMFI
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P54819
UniProtKB/Swiss-Prot Entry Name KAD2_HUMAN
PDB IDs
GenBank Gene ID U39945
GeneCard ID AK2
GenAtlas ID AK2
HGNC ID HGNC:362
References
General References
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  6. Lee Y, Kim JW, Lee IA, Kang HB, Choe YK, Lee HG, Lim JS, Kim HJ, Park C, Choe IS: Cloning and characterization of cDNA for human adenylate kinase 2A. Biochem Mol Biol Int. 1996 Jul;39(4):833-42. [PubMed:8843353 ]
  7. Lee Y, Kim JW, Lee SM, Kim HJ, Lee KS, Park C, Choe IS: Cloning and expression of human adenylate kinase 2 isozymes: differential expression of adenylate kinase 1 and 2 in human muscle tissues. J Biochem. 1998 Jan;123(1):47-54. [PubMed:9504408 ]
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