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Showing Protein Electrogenic sodium bicarbonate cotransporter 4 (HMDBP05675)
Identification | ||||||||||||||||||||
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HMDB Protein ID | HMDBP05675 | |||||||||||||||||||
Secondary Accession Numbers |
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Name | Electrogenic sodium bicarbonate cotransporter 4 | |||||||||||||||||||
Synonyms |
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Gene Name | SLC4A5 | |||||||||||||||||||
Protein Type | Transporter | |||||||||||||||||||
Biological Properties | ||||||||||||||||||||
General Function | Involved in anion transport | |||||||||||||||||||
Specific Function | Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH | |||||||||||||||||||
Pathways | Not Available | |||||||||||||||||||
Reactions | Not Available | |||||||||||||||||||
GO Classification |
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Cellular Location |
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Gene Properties | ||||||||||||||||||||
Chromosome Location | Chromosome:2 | |||||||||||||||||||
Locus | 2p13 | |||||||||||||||||||
SNPs | SLC4A5 | |||||||||||||||||||
Gene Sequence |
>3414 bp ATGAAGGTGAAGGAGGAGAAGGCTGGGGTAGGAAAGCTGGACCACACTAACCACAGGAGG AGATTTCCGGATCAGAAAGAATGCCCTCCTATCCACATTGGGCTTCCAGTACCCACTTAC CCTCAAAGAAAAACTGACCAGAAGGGACATCTTTCAGGCCTGCAAAAAGTCCACTGGGGC CTGCGGCCAGACCAGCCACAGCAGGAACTGACTGGCCCAGGGAGTGGGGCAAGCAGCCAG GACAGCAGCATGGATCTTATCAGCAGGACTCGGTCCCCAGCTGCTGAGCAGCTCCAGGAC ATCCTGGGGGAGGAAGATGAGGCTCCCAACCCCACCCTCTTTACAGAGATGGATACTCTG CAGCATGACGGAGACCAGATGGAGTGGAAGGAGTCAGCCAGGTGGATAAAGTTTGAAGAA AAGGTAGAGGAAGGCGGCGAACGCTGGAGCAAGCCCCACGTGTCCACACTATCCCTGCAC AGCCTCTTCGAGCTCCGTACCTGCCTGCAGACGGGGACGGTGCTGCTGGATTTGGACAGT GGCTCCTTACCACAGATCATAGATGATGTCATTGAGAAGCAGATTGAGGATGGTCTCCTG CGGCCAGAGCTCCGGGAGAGGGTCAGTTACGTCCTCCTGAGGAGGCACCGCCACCAAACC AAGAAGCCCATCCACCGCTCCTTAGCTGACATTGGGAAGTCAGTCTCCACCACAAATCGC AGTCCTGCCCGGAGCCCTGGTGCTGGCCCGAGTCTACACCACTCCACGGAAGACCTGCGG ATGCGGCAGAGTGCAAATTACGGACGTCTGTGTCATGCCCAGAGCAGAAGCATGAATGAC ATTTCTCTCACCCCAAACACAGACCAGCGGAAAAACAAATTCATGAAGAAGATCCCCAAG GACTCAGAAGCGTCCAACGTGCTCGTGGGCGAGGTGGACTTCCTAGACCAGCCATTCATC GCGTTCGTGCGCCTCATCCAGTCGGCCATGCTGGGAGGAGTGACCGAGGTGCCTGTCCCC ACCAGATTTCTGTTTATACTACTGGGACCTTCTGGGAGAGCAAAATCCTACAATGAAATT GGCCGTGCCATTGCAACCCTCATGGTAGATGATCTCTTCAGTGACGTGGCCTACAAAGCC CGCAATCGGGAAGATCTGATCGCAGGAATTGATGAATTTCTGGATGAGGTCATCGTCCTT CCTCCTGGAGAATGGGACCCAAATATCCGGATTGAGCCCCCCAAGAAGGTGCCCTCTGCT GACAAGAGGAAATCTGTGTTCTCCCTAGCAGAGCTGGGCCAGATGAATGGCTCTGTGGGA GGAGGCGGCGGAGCTCCTGGAGGAGGCAATGGAGGTGGTGGTGGTGGTGGCAGTGGCGGC GGGGCTGGCAGTGGCGGGGCCGGCGGAACAAGCAGCGGGGATGATGGAGAGATGCCAGCC ATGCATGAAATCGGGGAGGAACTTATCTGGACAGGAAGGTTCTTCGGTGGCCTGTGTCTG GATATCAAGAGGAAGTTGCCCTGGTTCCCAAGTGACTTCTATGATGGCTTCCACATTCAG TCCATCTCTGCCATCCTATTCATCTACCTCGGCTGTATCACCAACGCGATCACCTTTGGT GGGCTTCTGGGGGATGCCACCGACAATTATCAGGGAGTGATGGAGAGCTTCCTGGGCACT GCCATGGCTGGCTCCTTGTTCTGCCTCTTCTCGGGACAGCCTCTCATCATTCTCAGCAGC ACGGGGCCCATCCTCATCTTTGAGAAGCTCCTCTTCGACTTCAGCAAAGGCAATGGCCTG GACTACATGGAGTTCCGCCTCTGGATTGGCCTACACTCAGCTGTCCAGTGCCTTATCCTA GTGGCCACAGATGCCAGCTTTATCATCAAATATATCACCCGCTTCACCGAGGAGGGCTTC TCCACCCTTATCAGCTTCATCTTCATCTACGATGCCATCAAGAAGATGATCGGTGCCTTC AAGTACTACCCTATCAATATGGACTTCAAGCCAAACTTCATCACTACCTACAAGTGCGAG TGTGTCGCCCCTGACACAGTGAATACAACCGTGTTCAATGCTTCAGCCCCATTGGCACCA GACACCAACGCTTCTCTGTACAACCTCCTTAACCTCACAGCGTTGGACTGGTCCCTGCTG AGCAAGAAGGAGTGTCTGAGCTACGGCGGGCGCCTGCTTGGGAATTCCTGCAAGTTTATC CCAGACCTGGCGCTCATGTCCTTCATCCTTTTCTTTGGGACATACTCCATGACCCTGACC CTGAAGAAGTTCAAATTCAGCCGCTATTTTCCTACCAAGGTCCGGGCCCTGGTGGCTGAC TTTTCCATTGTTTTCTCCATCCTGATGTTCTGTGGAATCGATGCCTGTTTTGGCCTAGAA ACTCCCAAGCTGCATGTGCCCAGTGTCATCAAGCCAACGCGGCCTGACCGAGGCTGGTTC GTGGCCCCCTTTGGGAAGAACCCGTGGTGGGTATACCCAGCAAGCATCCTGCCCGCCCTG CTGGTGACCATCCTGATCTTCATGGACCAGCAGATCACTGCCGTCATTGTCAACCGGAAG GAGAACAAACTGAAGAAGGCTGCCGGCTACCATCTGGACCTGTTCTGGGTGGGCATCCTC ATGGCTTTGTGCTCCTTTATGGGGCTCCCCTGGTACGTGGCTGCCACGGTCATCTCCATC GCCCACATCGACAGCCTCAAGATGGAGACAGAGACCAGTGCCCCTGGGGAGCAGCCCCAG TTTCTGGGAGTCAGGGAACAGAGAGTAACCGGCATCATCGTCTTCATCCTGACGGGAATC TCTGTCTTCCTGGCTCCCATCCTAAAGTGTATCCCCCTGCCGGTGCTGTACGGAGTCTTC CTCTACATGGGCGTGGCCTCCCTGAATGGCATCCAGATGGGGACCGGAGGGTCAGAATTC AAAATCCAGAAGAAGCTGACTCCATTCTGGGAACGCTGCAAGCTCTTCCTGATGCCAGCC AAGCACCAGCCGGACCATGCCTTCCTGCGGCACGTGCCGCTGCGCCGGATCCACCTCTTC ACCCTGGTGCAGATCCTCTGCCTGGCGGTGCTCTGGATCCTCAAATCCACGGTGGCTGCC ATCATCTTCCCGGTCATGATCCTGGGCCTCATCATCGTTCGAAGGCTTCTGGATTTCATC TTTTCCCAGCACGACCTGGCCTGGATTGACAACATCCTCCCAGAGAAGGAAAAAAAGGAG ACAGACAAGAAGAGGAAGAGAAAAAAAGGGGCCCACGAGGACTGTGATGAGGAGCCCCAG TTCCCTCCTCCCTCGGTTATAAAGATTCCCATGGAAAGTGTCCAATCAGATCCCCAAAAC GGTATCCACTGCATTGCCAGAAAAAGATCTTCCAGTTGGAGTTACTCACTCTGA |
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Protein Properties | ||||||||||||||||||||
Number of Residues | 1137 | |||||||||||||||||||
Molecular Weight | 126254.0 | |||||||||||||||||||
Theoretical pI | 7.98 | |||||||||||||||||||
Pfam Domain Function | ||||||||||||||||||||
Signals |
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Transmembrane Regions |
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Protein Sequence |
>Electrogenic sodium bicarbonate cotransporter 4 MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWG LRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTL QHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDS GSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNR SPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPK DSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEI GRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSA DKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPA MHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFG GLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGL DYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAF KYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLL SKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVAD FSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPAL LVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISI AHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVF LYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLF TLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKE TDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL |
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External Links | ||||||||||||||||||||
GenBank ID Protein | 125987596 | |||||||||||||||||||
UniProtKB/Swiss-Prot ID | Q9BY07 | |||||||||||||||||||
UniProtKB/Swiss-Prot Entry Name | S4A5_HUMAN | |||||||||||||||||||
PDB IDs | Not Available | |||||||||||||||||||
GenBank Gene ID | NM_021196.3 | |||||||||||||||||||
GeneCard ID | SLC4A5 | |||||||||||||||||||
GenAtlas ID | SLC4A5 | |||||||||||||||||||
HGNC ID | HGNC:18168 | |||||||||||||||||||
References | ||||||||||||||||||||
General References |
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