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Identification
HMDB Protein ID HMDBP07376
Secondary Accession Numbers
  • 13030
Name Dihydrofolate reductase
Synonyms
  1. SubName: cDNA, FLJ93028, Homo sapiens dihydrofolate reductase (DHFR), mRNA
Gene Name DYR
Protein Type Enzyme
Biological Properties
General Function Involved in dihydrofolate reductase activity
Specific Function Not Available
Pathways
  • Folate Metabolism
Reactions Not Available
GO Classification
Function
binding
nucleotide binding
catalytic activity
oxidoreductase activity, acting on the ch-nh group of donors
nadp or nadph binding
oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor
oxidoreductase activity
dihydrofolate reductase activity
Process
metabolic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
nucleotide metabolic process
nucleotide biosynthetic process
cellular metabolic process
serine family amino acid metabolic process
glycine metabolic process
oxidation reduction
cellular amino acid and derivative metabolic process
glycine biosynthetic process
cellular amino acid metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs DYR
Gene Sequence
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA
Protein Properties
Number of Residues 187
Molecular Weight 21452.6
Theoretical pI 7.6
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
GenBank ID Protein 189069188
UniProtKB/Swiss-Prot ID B0YJ76
UniProtKB/Swiss-Prot Entry Name B0YJ76_HUMAN
PDB IDs
GenBank Gene ID AK312642
GeneCard ID DYR
GenAtlas ID DYR
HGNC ID HGNC:2861
References
General References
  1. Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF: Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols. Drug Metab Dispos. 2008 Mar;36(3):508-16. Epub 2007 Dec 3. [PubMed:18056255 ]