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Showing Protein Ubiquinone biosynthesis monooxygenase COQ6 (HMDBP07420)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 8 metabolites
Identification
HMDB Protein ID HMDBP07420
Secondary Accession Numbers
  • 13122
Name Ubiquinone biosynthesis monooxygenase COQ6
Synonyms
  1. Coenzyme Q10 monooxygenase 6
Gene Name COQ6
Protein Type Unknown
Biological Properties
General Function Involved in monooxygenase activity
Specific Function Not Available
Pathways
  • Ubiquinone and other terpenoid-quinone biosynthesis
  • ubiquinone biosynthesis
  • Ubiquinone Biosynthesis
Reactions
2-Hexaprenyl-6-methoxyphenol + Oxygen → 2-Hexaprenyl-6-methoxy-1,4-benzoquinone + Water details
2-Polyprenyl-6-methoxyphenol + Oxygen → 2-Polyprenyl-6-methoxy-1,4-benzoquinone + Water details
GO Classification
Biological Process
ubiquinone biosynthetic process
Cellular Component
cell projection
mitochondrion
Golgi apparatus
Function
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
monooxygenase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, nadh or nadph as one donor, and incorporation of one atom of oxygen
oxidoreductase activity
fad or fadh2 binding
Molecular Function
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
flavin adenine dinucleotide binding
Process
metabolic process
cellular metabolic process
oxidoreduction coenzyme metabolic process
ubiquinone metabolic process
ubiquinone biosynthetic process
oxidation reduction
cofactor metabolic process
coenzyme metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs COQ6
Gene Sequence 
>1407 bp
ATGGCGGCCCGGCTTGTCAGCCGATGCGGGGCTGTGCGTGCAGCTCCCCACAGCGGCCCG
CTGGCTGTCCTGGCGCAGGTGGTCCGGCGCTCAACAGACACCGTGTATGACGTGGTGGTG
TCGGGTGGAGGCCTGGTGGGCGCTGCCATGGCCTGTGCCTTGGGATATGATATTCACTTT
CATGACAAGAAAATCCTGTTGCTCGAAGCAGGTCCAAAGAAAGTACTGGAGAAATTGTCA
GAAACTTACAGCAACAGGGTCAGCTCCATTTCCCCTGGCTCTGCAACGCTTCTCAGTAGT
TTTGGTGCCTGGGACCATATCTGCAACATGAGATACAGAGCCTTTCGGCGAATGCAGGTG
TGGGACGCCTGCTCAGAGGCCCTGATAATGTTTGATAAGGATAATTTAGATGACATGGGC
TATATCGTGGAGAATGATGTCATCATGCATGCTCTCACTAAGCAGTTGGAGGCTGTGTCT
GACCGAGTGACGGTTCTCTACAGGAGCAAAGCCATTCGCTATACCTGGCCTTGTCCATTT
CCTATGGCCGACTCCAGCCCTTGGGTTCATATTACCCTAGGTGATGGCAGCACCTTCCAG
ACCAAATTGTTGATAGGTGCAGATGGTCACAACTCCGGAGTACGGCAGGCTGTTGGAATC
CAGAATGTGAGCTGGAACTATGACCAGTCTGCTGTTGTGGCTACTCTGCATTTATCAGAG
GCCACAGAAAACAACGTAGCCTGGCAGAGATTTCTTCCCTCTGGGCCTATTGCTCTGCTC
CCGCTCTCAGACACCTTGAGTTCCTTGGTTTGGTCCACGTCCCATGAACATGCAGCAGAG
CTAGTTAGCATGGATGAGGAAAAATTTGTGGATGCCGTTAACTCTGCCTTTTGGAGTGAT
GCTGACCACACGGACTTCATCGACACAGCTGGTGCCATGCTGCAGTATCCTGTCAGCCTT
CTGAAGCCCACTAAGGTCTCGGCTCGCCAGCTGCCCCCAAGCGTACCATGGGTGGATGCC
AAAAGCCGAGTTCTGTTTCCTCTTGGGTTGGGACATGCTGCTGAGTACGTCAGGCCTCGG
GTGGCGCTCATTGGGGATGCAGCCCACAGAGTCCATCCGCTTGCAGGACAGGGTGTCAAC
ATGGGCTTTGGGGATATCTCCAGCTTGGCCCATCACCTCAGTACGGCAGCCTTCAATGGG
AAGGACTTAGGTTCCGTGAGCCACCTCACAGGTTATGAAACAGAAAGACAGCGTCACAAC
ACTGCTCTTCTGGCTGCTACAGACTTACTAAAAAGGCTCTATTCTACCAGTGCCTCCCCG
CTTGTGTTGCTCAGGACGTGGGGCTTGCAGGCCACAAATGCAGTGTCTCCACTCAAAGAA
CAGATTATGGCCTTTGCAAGCAAATGA
Protein Properties
Number of Residues 468
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Ubiquinone biosynthesis monooxygenase COQ6
MAARLVSRCGAVRAAPHSGPLVSWRRWSGASTDTVYDVVVSGGGLVGAAMACALGYDIHF
HDKKILLLEAGPKKVLEKLSETYSNRVSSISPGSATLLSSFGAWDHICNMRYRAFRRMQV
WDACSEALIMFDKDNLDDMGYIVENDVIMHALTKQLEAVSDRVTVLYRSKAIRYTWPCPF
PMADSSPWVHITLGDGSTFQTKLLIGADGHNSGVRQAVGIQNVSWNYDQSAVVATLHLSE
ATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHEHAAELVSMDEEKFVDAVNSAFWSD
ADHTDFIDTAGAMLQYAVSLLKPTKVSARQLPPSVARVDAKSRVLFPLGLGHAAEYVRPR
VALIGDAAHRVHPLAGQGVNMGFGDISSLAHHLSTAAFNGKDLGSVSHLTGYETERQRHN
TALLAATDLLKRLYSTSASPLVLLRTWGLQATNAVSPLKEQIMAFASK
GenBank ID Protein 4680659
UniProtKB/Swiss-Prot ID Q9Y2Z9
UniProtKB/Swiss-Prot Entry Name COQ6_HUMAN
PDB IDs Not Available
GenBank Gene ID AF132944
GeneCard ID COQ6
GenAtlas ID COQ6
HGNC ID HGNC:20233
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 2000 May;10(5):703-13. [PubMed:10810093 ]