Hmdb loader
Survey
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Identification
HMDB Protein ID HMDBP07520
Secondary Accession Numbers
  • 13228
Name Cadherin-4
Synonyms
  1. R-CAD
  2. R-cadherin
  3. Retinal cadherin
Gene Name CDH4
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
membrane part
plasma membrane
intrinsic to membrane
integral to membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13.3
SNPs CDH4
Gene Sequence
>2751 bp
ATGACCGCGGGCGCCGGCGTGCTCCTTCTGCTGCTCTCGCTCTCCGGCGCGCTCCGGGCC
CATAATGAGGATCTTACAACTAGAGAGACCTGCAAGGCTGGGTTCTCTGAAGATGATTAC
ACGGCATTAATCTCCCAAAATATTCTAGAAGGGGAAAAGCTACTTCAAGTCAAGTTCAGC
AGCTGTGTGGGGACCAAGGGGACACAATATGAGACCAACAGCATGGACTTCAAAGTTGGG
GCAGATGGGACAGTCTTCGCCACCCGGGAGCTGCAGGTCCCCTCCGAGCAGGTGGCGTTC
ACGGTGACTGCATGGGACAGCCAGACAGCAGAGAAATGGGACGCCGTGGTGCGGTTGCTG
GTGGCCCAGACCTCGTCCCCGCACTCTGGACACAAGCCGCAGAAAGGAAAGAAGGTCGTG
GCTCTGGACCCCTCTCCGCCTCCGAAGGACACCCTGCTGCCGTGGCCCCAGCACCAGAAC
GCCAACGGGCTGAGGCGGCGCAAACGGGACTGGGTCATCCCGCCCATCAACGTGCCCGAG
AACTCGCGCGGGCCCTTCCCGCAGCAGCTCGTGAGGATCCGGTCCGACAAAGACAATGAC
ATCCCCATCCGGTACAGCATCACGGGAGTGGGCGCCGACCAGCCCCCCATGGAGGTCTTC
AGCATTGACTCCATGTCCGGCCGGATGTACGTCACAAGGCCCATGGACCGGGAGGAGCAC
GCCTCTTACCACCTCCGAGCCCACGCTGTGGACATGAATGGCAACAAGGTGGAGAACCCC
ATCGACCTGTACATCTACGTCATCGACATGAATGACAACCGCCCTGAGTTCATCAACCAG
GTCTACAACGGCTCCGTGGACGAGGGCTCCAAGCCAGGCACCTACGTGATGACCGTCACG
GCCAACGATGCTGACGACAGCACCACGGCCAACGGGATGGTGCGGTACCGGATCGTGACC
CAGACCCCACAGAGCCCGTCCCAGAATATGTTCACCATCAACAGCGAGACTGGAGATATC
GTCACAGTGGCGGCTGGCCTGGACCGAGAGAAAGTTCAGCAGTACACAGTCATCGTTCAG
GCCACAGATATGGAAGGAAATCTCAACTATGGCCTCTCAAACACAGCCACAGCCATCATC
ACGGTGACAGATGTGAATGACAACCCGCCAGAATTTACCGCCAGCACGTTTGCAGGGGAG
GTCCCCGAAAACCGCGTGGAGACCGTGGTCGCAAACCTCACGGTGATGGACCGAGATCAG
CCCCACTCTCCAAACTGGAATGCCGTTTACCGCATCATCAGTGGGGATCCATCCGGGCAC
TTCAGCGTCCGCACAGACCCCGTAACCAACGAGGGCATGGTCACCGTGGTGAAGGCAGTC
GACTACGAGCTCAACAGAGCTTTCATGCTGACAGTGATGGTGTCCAACCAGGCGCCCCTG
GCCAGCGGAATCCAGATGTCCTTCCAGTCCACGGCAGGGGTGACCATCTCCATCATGGAC
ATCAACGAGGCTCCCTACTTCCCCTCAAACCACAAGCTGATCCGCCTGGAGGAGGGCGTG
CCCCCCGGCACCGTGCTGACCACGTTTTCAGCTGTGGACCCTGACCGGTTCATGCAGCAG
GCTGTGAGATACTCAAAGCTGTCAGACCCAGCGAGCTGGCTGCACATCAATGCCACCAAC
GGCCAGATCACCACGGCGGCAGTGCTGGACCGTGAGTCCCTCTACACCAAAAACAACGTC
TACGAGGCCACCTTCCTGGCAGCTGACAATGGGATACCCCCGGCCAGCGGCACCGGGACC
CTCCAGATCTATCTCATTGACATCAACGACAACGCCCCTGAGCTGCTGCCCAAGGAGGCG
CAGATCTGCGAGAAGCCCAACCTGAACGCCATCAACATCACGGCGGCCGACGCTGACGTC
GACCCCAACATCGGCCCCTACGTCTTCGAGCTGCCCTTTGTCCCGGCGGCCGTGCGGAAG
AACTGGACCATCACCCGCCTGAACGGTGACTATGCCCAACTCAGCTTGCGCATCCTGTAC
CTGGAGGCCGGGATGTATGACGTCCCCATCATCGTCACAGACTCTGGAAACCCTCCCCTG
TCCAACACGTCCATCATCAAAGTCAAGGTGTGCCCATGTGATGACAACGGGGACTGCACC
ACCATTGGCGCAGTGGCAGCGGCTGGTCTGGGCACCGGTGCCATCGTGGCCATCCTCATC
TGCATCCTCATCCTGCTGACCATGGTCCTGCTGTTTGTCATGTGGATGAAGCGGCGAGAG
AAGGAGCGCCACACGAAGCAGCTGCTCATTGACCCCGAGGACGACGTCCGCGACAACATC
CTCAAGTATGACGAGGAAGGCGGTGGCGAGGAGGACCAGGACTACGACCTCAGCCAGCTG
CAGCAGCCGGAAGCCATGGGGCACGTGCCAAGCAAAGCCCCTGGCGTGCGTCGCGTGGAT
GAGCGGCCGGTGGGCGCTGAGCCCCAGTACCCGATCAGGCCCATGGTGCCGCACCCAGGC
GACATCGGTGACTTCATCAATGAGGGACTCCGCGCTGCTGACAACGACCCCACGGCACCC
CCCTATGACTCCCTGCTGGTCTTCGACTACGAGGGGAGCGGCTCCACCGCAGGCTCCGTC
AGCTCCCTGAACTCATCCAGTTCCGGGGACCAAGACTACGATTACCTCAACGACTGGGGG
CCCAGATTCAAGAAGCTGGCGGACATGTATGGAGGTGGTGAAGAGGATTGA
Protein Properties
Number of Residues 916
Molecular Weight 100279.7
Theoretical pI 4.41
Pfam Domain Function
Signals
  • 1-20
Transmembrane Regions
  • 735-756
Protein Sequence
>Cadherin-4
MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEGEKLLQVKFS
SCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLL
VAQTSSPHSGHKPQKGKKVVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPE
NSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMYVTRPMDREEH
ASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVT
ANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQ
ATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQ
PHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPL
ASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQ
AVRYSKLSDPASWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGT
LQIYLIDINDNAPELLPKEAQICEKPNLNAINITAADADVDPNIGPYVFELPFVPAAVRK
NWTITRLNGDYAQLSLRILYLEAGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCT
TIGAVAAAGLGTGAIVAILICILILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNI
LKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAPGVRRVDERPVGAEPQYPIRPMVPHPG
DIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNSSSSGDQDYDYLNDWG
PRFKKLADMYGGGEED
GenBank ID Protein 56204141
UniProtKB/Swiss-Prot ID P55283
UniProtKB/Swiss-Prot Entry Name CADH4_HUMAN
PDB IDs Not Available
GenBank Gene ID AL109911
GeneCard ID CDH4
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Deloukas P, Matthews LH, Ashurst J, Burton J, Gilbert JG, Jones M, Stavrides G, Almeida JP, Babbage AK, Bagguley CL, Bailey J, Barlow KF, Bates KN, Beard LM, Beare DM, Beasley OP, Bird CP, Blakey SE, Bridgeman AM, Brown AJ, Buck D, Burrill W, Butler AP, Carder C, Carter NP, Chapman JC, Clamp M, Clark G, Clark LN, Clark SY, Clee CM, Clegg S, Cobley VE, Collier RE, Connor R, Corby NR, Coulson A, Coville GJ, Deadman R, Dhami P, Dunn M, Ellington AG, Frankland JA, Fraser A, French L, Garner P, Grafham DV, Griffiths C, Griffiths MN, Gwilliam R, Hall RE, Hammond S, Harley JL, Heath PD, Ho S, Holden JL, Howden PJ, Huckle E, Hunt AR, Hunt SE, Jekosch K, Johnson CM, Johnson D, Kay MP, Kimberley AM, King A, Knights A, Laird GK, Lawlor S, Lehvaslaiho MH, Leversha M, Lloyd C, Lloyd DM, Lovell JD, Marsh VL, Martin SL, McConnachie LJ, McLay K, McMurray AA, Milne S, Mistry D, Moore MJ, Mullikin JC, Nickerson T, Oliver K, Parker A, Patel R, Pearce TA, Peck AI, Phillimore BJ, Prathalingam SR, Plumb RW, Ramsay H, Rice CM, Ross MT, Scott CE, Sehra HK, Shownkeen R, Sims S, Skuce CD, Smith ML, Soderlund C, Steward CA, Sulston JE, Swann M, Sycamore N, Taylor R, Tee L, Thomas DW, Thorpe A, Tracey A, Tromans AC, Vaudin M, Wall M, Wallis JM, Whitehead SL, Whittaker P, Willey DL, Williams L, Williams SA, Wilming L, Wray PW, Hubbard T, Durbin RM, Bentley DR, Beck S, Rogers J: The DNA sequence and comparative analysis of human chromosome 20. Nature. 2001 Dec 20-27;414(6866):865-71. [PubMed:11780052 ]
  3. Tanihara H, Sano K, Heimark RL, St John T, Suzuki S: Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin. Cell Adhes Commun. 1994 Apr;2(1):15-26. [PubMed:7982033 ]
  4. Suzuki S, Sano K, Tanihara H: Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regul. 1991 Apr;2(4):261-70. [PubMed:2059658 ]