| Identification |
|---|
| HMDB Protein ID
| HMDBP07547 |
| Secondary Accession Numbers
| |
| Name
| Calpain-7 |
| Synonyms
|
- PalB homolog
- PalBH
|
| Gene Name
| CAPN7 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium-dependent cysteine-type endopeptidase activity |
| Specific Function
| Calcium-regulated non-lysosomal thiol-protease |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| endopeptidase activity |
| cysteine-type endopeptidase activity |
| catalytic activity |
| hydrolase activity |
| calcium-dependent cysteine-type endopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Nucleus
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p24 |
| SNPs
| CAPN7 |
| Gene Sequence
|
>2442 bp
ATGGACGCCACAGCACTGGAGCGGGACGCTGTGCAGTTCGCCCGTCTGGCGGTTCAGCGC
GACCACGAAGGCCGCTACTCCGAGGCGGTGTTTTATTACAAGGAAGCTGCACAAGCCTTA
ATTTATGCTGAGATGGCAGGATCAAGCCTAGAAAATATTCAAGAAAAAATAACTGAGTAT
CTGGAAAGAGTTCAAGCTCTACATTCAGCAGTTCAGTCAAAGAGTGCTGATCCTTTGAAG
TCAAAACATCAGTTGGACTTAGAGCGTGCTCATTTCCTTGTTACACAAGCTTTTGATGAA
GATGAAAAAGAGAATGTTGAAGATGCTATAGAATTGTACACAGAAGCTGTGGATCTCTGT
CTGAAAACATCTTATGAAACTGCTGATAAAGTCCTGCAAAATAAACTGAAACAGTTGGCT
CGACAGGCACTAGACAGAGCAGAAGCGCTGAGTGAGCCTTTGACCAAGCCAGTTGGCAAA
ATCAGTTCAACAAGTGTTAAGCCAAAGCCACCTCCAGTGAGAGCACATTTTCCACTGGGC
GCTAATCCCTTCCTTGAAAGACCTCAGTCATTTATAAGTCCTCAGTCATGTGATGCACAA
GGACAGAGATACACAGCAGAAGAAATAGAAGTACTCAGGACAACATCAAAAATAAATGGT
ATAGAATATGTTCCTTTCATGAATGTTGACCTGAGAGAACGTTTTGCCTATCCAATGCCT
TTCTGTGATAGATGGGGCAAGCTACCATTATCACCTAAACAAAAAACTACATTTTCCAAG
TGGGTACGACCAGAAGACCTCACCAACAATCCTACAATGATATATACTGTGTCCAGTTTT
AGCATAAAGCAGACAATAGTATCGGATTGCTCCTTTGTGGCATCACTGGCCATCAGTGCA
GCTTATGAAAGACGTTTTAATAAGAAGTTAATTACCGGCATAATTTACCCTCAAAACAAG
GATGGTGAACCAGAATACAATCCATGTGGGAAGTATATGGTAAAACTTCACCTCAATGGT
GTCCCAAGAAAGGTGATAATTGATGACCAGTTACCTGTTGATCACAAGGGAGAATTGCTC
TGTTCTTATTCCAACAACAAAAGTGAATTATGGGTTTCTCTCATAGAAAAAGCATACATG
AAAGTCATGGGAGGATATGATTTTCCAGGATCCAACTCCAATATTGATCTTCATGCACTG
ACTGGCTGGATACCAGAAAGAATTGCTATGCATTCAGATAGCCAAACTTTCAGTAAGGAT
AATTCTTTCAGAATGCTTTATCAAAGATTTCACAAGGGAGATGTCCTCATCACTGCGTCA
ACTGGAATGATGACAGAAGCTGAAGGAGAGAAGTGGGGTCTGGTTCCCACACACGCATAT
GCTGTTTTGGATATTAGAGAGTTCAAGGGGCTGCGATTTATCCAGTTGAAAAATCCTTGG
AGTCATTTACGTTGGAAAGGAAGATACAGTGAAAATGATGTAAAAAACTGGACTCCAGAG
TTGCAAAAGTATTTAAACTTTGATCCCCGAACAGCTCAGAAAATAGACAACGGAATATTT
TGGATTTCCTGGGATGATCTCTGCCAGTATTATGATGTGATTTATTTGAGTTGGAATCCA
GGTCTTTTTAAAGAATCAACATGTATTCACAGTACTTGGGATGCTAAGCAAGGACCTGTG
AAAGATGCCTATAGCCTGGCCAACAACCCCCAGTACAAACTGGAGGTGCAGTGTCCACAG
GGGGGTGCTGCAGTTTGGGTTTTGCTTAGTAGACACATAACAGACAAGGATGATTTTGCG
AATAATCGAGAATTTATCACAATGGTTGTATACAAGACTGATGGGAAAAAAGTTTATTAC
CCAGCTGACCCACCTCCATACATTGATGGAATTCGAATTAACAGCCCTCATTATTTGACT
AAGATAAAGCTGACCACACCTGGCACCCATACCTTTACATTAGTGGTTTCTCAATATGAA
AAACAGAACACAATCCATTACACGGTTCGGGTATATTCAGCATGCAGCTTTACTTTTTCA
AAGATTCCTTCACCATACACCTTATCAAAACGGATTAATGGAAAGTGGAGTGGTCAGAGT
GCTGGAGGATGTGGAAATTTCCAAGAGACTCACAAAAATAACCCCATCTACCAATTCCAT
ATAGAAAAGACTGGGCCGTTACTGATTGAGCTACGAGGACCAAGGCAATATAGCGTTGGA
TTTGAGGTTGTAACAGTTTCTACTCTAGGAGATCCTGGTCCCCATGGCTTTCTGAGGAAA
TCTAGTGGTGACTATAGGTGTGGGTTTTGCTACCTGGAATTAGAAAATATACCTTCTGGG
ATCTTCAATATCATTCCTAGTACCTTTTTGCCTAAACAAGAAGGACCTTTTTTCTTGGAC
TTTAATAGTATTATCCCCATCAAGATCACACAACTTCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 813 |
| Molecular Weight
| 92651.6 |
| Theoretical pI
| 7.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calpain-7
MDATALERDAVQFARLAVQRDHEGRYSEAVFYYKEAAQALIYAEMAGSSLENIQEKITEY
LERVQALHSAVQSKSADPLKSKHQLDLERAHFLVTQAFDEDEKENVEDAIELYTEAVDLC
LKTSYETADKVLQNKLKQLARQALDRAEALSEPLTKPVGKISSTSVKPKPPPVRAHFPLG
ANPFLERPQSFISPQSCDAQGQRYTAEEIEVLRTTSKINGIEYVPFMNVDLRERFAYPMP
FCDRWGKLPLSPKQKTTFSKWVRPEDLTNNPTMIYTVSSFSIKQTIVSDCSFVASLAISA
AYERRFNKKLITGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELL
CSYSNNKSELWVSLIEKAYMKVMGGYDFPGSNSNIDLHALTGWIPERIAMHSDSQTFSKD
NSFRMLYQRFHKGDVLITASTGMMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPW
SHLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVIYLSWNP
GLFKESTCIHSTWDAKQGPVKDAYSLANNPQYKLEVQCPQGGAAVWVLLSRHITDKDDFA
NNREFITMVVYKTDGKKVYYPADPPPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYE
KQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWSGQSAGGCGNFQETHKNNPIYQFH
IEKTGPLLIELRGPRQYSVGFEVVTVSTLGDPGPHGFLRKSSGDYRCGFCYLELENIPSG
IFNIIPSTFLPKQEGPFFLDFNSIIPIKITQLQ
|
| External Links |
|---|
| GenBank ID Protein
| 5102944 |
| UniProtKB/Swiss-Prot ID
| Q9Y6W3 |
| UniProtKB/Swiss-Prot Entry Name
| CAN7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB028639 |
| GeneCard ID
| CAPN7 |
| GenAtlas ID
| CAPN7 |
| HGNC ID
| HGNC:1484 |
| References |
|---|
| General References
| - Futai E, Kubo T, Sorimachi H, Suzuki K, Maeda T: Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB. Biochim Biophys Acta. 2001 Jan 26;1517(2):316-9. [PubMed:11342116 ]
|
