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Identification
HMDB Protein ID HMDBP07590
Secondary Accession Numbers
  • 13298
Name C-type lectin domain family 4 member K
Synonyms
  1. CD207 antigen
  2. Langerin
Gene Name CD207
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Calcium-dependent lectin displaying mannose-binding specificity, Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
Cellular Location
  1. Membrane
  2. Single-pass type II membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 2p13
SNPs CD207
Gene Sequence
>987 bp
ATGACTGTGGAGAAGGAGGCCCCTGATGCGCACTTCACTGTGGACAAACAGAACATCTCC
CTCTGGCCCCGAGAGCCTCCTCCCAAGTCCGGTCCATCTCTGGTCCCGGGGAAAACACCC
ACAGTCCGTGCTGCATTAATCTGCCTGACGCTGGTCCTGGTCGCCTCCGTCCTGCTGCAG
GCCGTCCTTTATCCCCGGTTTATGGGCACCATATCAGATGTAAAGACCAATGTCCAGTTG
CTGAAAGGTCGTGTGGACAACATCAGCACCCTGGATTCTGAAATTAAAAAGAATAGTGAC
GGCATGGAGGCAGCTGGCGTTCAGATCCAGATGGTGAATGAGAGCCTGGGTTATGTGCGT
TCTCAGTTCCTGAAGTTAAAAACCAGTGTGGAGAAGGCCAACGCACAGATCCAGATCTTA
ACAAGAAGTTGGGAAGAAGTCAGTACCTTAAATGCCCAAATCCCAGAGTTAAAAAGTGAT
TTGGAGAAAGCCAGTGCTTTAAATACAAAGATCCGGGCACTCCAGGGCAGCTTGGAGAAT
ATGAGCAAGTTGCTCAAACGACAAAATGATATTCTACAGGTGGTTTCTCAAGGCTGGAAG
TACTTCAAGGGGAACTTCTATTACTTTTCTCTCATTCCAAAGACCTGGTATAGTGCCGAG
CAGTTCTGTGTGTCCAGGAATTCACACCTGACCTCGGTGACCTCAGAGAGTGAGCAGGAG
TTTCTGTATAAAACAGCGGGGGGACTCATCTACTGGATTGGCCTGACTAAAGCAGGGATG
GAAGGGGACTGGTCCTGGGTGGATGACACGCCATTCAACAAGGTCCAAAGTGCGAGGTTC
TGGATTCCAGGTGAGCCCAACAATGCTGGGAACAATGAACACTGTGGCAATATAAAGGCT
CCCTCACTTCAGGCCTGGAATGATGCCCCATGTGACAAAACGTTTCTTTTCATTTGTAAG
CGACCCTATGTCCCATCAGAACCGTGA
Protein Properties
Number of Residues 328
Molecular Weight 36724.8
Theoretical pI 8.44
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 44-64
Protein Sequence
>C-type lectin domain family 4 member K
MTVEKEAPDAHFTVDKQNISLWPREPPPKSGPSLVPGKTPTVRAALICLTLVLVASVLLQ
AVLYPRFMGTISDVKTNVQLLKGRVDNISTLDSEIKKNSDGMEAAGVQIQMVNESLGYVR
SQFLKLKTSVEKANAQIQILTRSWEEVSTLNAQIPELKSDLEKASALNTKIRALQGSLEN
MSKLLKRQNDILQVVSQGWKYFKGNFYYFSLIPKTWYSAEQFCVSRNSHLTSVTSESEQE
FLYKTAGGLIYWIGLTKAGMEGDWSWVDDTPFNKVQSVRFWIPGEPNNAGNNEHCGNIKA
PSLQAWNDAPCDKTFLFICKRPYVPSEP
GenBank ID Protein 305410858
UniProtKB/Swiss-Prot ID Q9UJ71
UniProtKB/Swiss-Prot Entry Name CLC4K_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015717.3
GeneCard ID CD207
GenAtlas ID CD207
HGNC ID HGNC:17935
References
General References
  1. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK: Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Nature. 2005 Apr 7;434(7034):724-31. [PubMed:15815621 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Valladeau J, Ravel O, Dezutter-Dambuyant C, Moore K, Kleijmeer M, Liu Y, Duvert-Frances V, Vincent C, Schmitt D, Davoust J, Caux C, Lebecque S, Saeland S: Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000 Jan;12(1):71-81. [PubMed:10661407 ]
  4. Valladeau J, Dezutter-Dambuyant C, Saeland S: Langerin/CD207 sheds light on formation of birbeck granules and their possible function in Langerhans cells. Immunol Res. 2003;28(2):93-107. [PubMed:14610287 ]
  5. Thepaut M, Valladeau J, Nurisso A, Kahn R, Arnou B, Vives C, Saeland S, Ebel C, Monnier C, Dezutter-Dambuyant C, Imberty A, Fieschi F: Structural studies of langerin and Birbeck granule: a macromolecular organization model. Biochemistry. 2009 Mar 31;48(12):2684-98. doi: 10.1021/bi802151w. [PubMed:19175323 ]