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Identification
HMDB Protein ID HMDBP07599
Secondary Accession Numbers
  • 13308
Name Claudin-16
Synonyms
  1. PCLN-1
  2. Paracellin-1
Gene Name CLDN16
Protein Type Unknown
Biological Properties
General Function Involved in structural molecule activity
Specific Function Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Involved in paracellular magnesium reabsorption. Required for a selective paracellular conductance. May form, alone or in partnership with other constituents, an intercellular pore permitting paracellular passage of magnesium and calcium ions down their electrochemical gradients. Alternatively, it could be a sensor of magnesium concentration that could alter paracellular permeability mediated by other factors
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell-cell junction
occluding junction
tight junction
membrane
cell part
membrane part
plasma membrane part
cell junction
Function
structural molecule activity
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
  3. Cell junction
  4. tight junction
Gene Properties
Chromosome Location Chromosome:3
Locus 3q28
SNPs CLDN16
Gene Sequence
>918 bp
ATGACCTCCAGGACCCCACTGTTGGTTACAGCCTGTTTGTATTATTCTTACTGCAACTCA
AGACACCTGCAGCAGGGCGTGAGAAAAAGTAAAAGACCAGTATTTTCACATTGCCAGGTA
CCAGAAACACAGAAGACTGACACCCGCCACTTAAGTGGGGCCAGGGCTGGTGTCTGCCCA
TGTTGCCATCCTGATGGGCTGCTTGCCACAATGAGGGATCTTCTTCAATACATCGCTTGC
TTCTTTGCCTTTTTCTCTGCTGGGTTTTTGATTGTGGCCACCTGGACTGACTGTTGGATG
GTGAATGCTGATGACTCTCTGGAGGTGAGCACAAAATGCCGAGGCCTCTGGTGGGAATGC
GTCACAAATGCTTTTGATGGGATTCGCACCTGTGATGAGTACGATTCCATACTTGCGGAG
CATCCCTTGAAGCTGGTGGTAACTCGAGCGTTGATGATTACTGCAGATATTCTAGCTGGG
TTTGGATTTCTCACCCTGCTCCTTGGTCTTGACTGCGTGAAATTCCTCCCTGATGAGCCG
TACATTAAAGTCCGCATCTGCTTTGTTGCTGGAGCCACGTTACTAATAGCAGGTACCCCA
GGAATCATTGGCTCTGTGTGGTATGCTGTTGATGTGTATGTGGAACGTTCTACTTTGGTT
TTGCACAATATATTTCTTGGTATCCAATATAAATTTGGTTGGTCCTGTTGGCTCGGAATG
GCTGGGTCTCTGGGTTGCTTTTTGGCTGGAGCTGTTCTCACCTGCTGCTTATATCTTTTT
AAAGATGTTGGACCTGAGAGAAACTATCCTTATTCCTTGAGGAAAGCCTATTCAGCCGCG
GGTGTTTCCATGGCCAAGTCATACTCAGCCCCTCGCACAGAGACGGCCAAAATGTATGCT
GTAGACACAAGGGTGTAA
Protein Properties
Number of Residues 305
Molecular Weight 33836.1
Theoretical pI 7.97
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 74-94
  • 151-171
  • 186-206
  • 240-260
Protein Sequence
>Claudin-16
MTSRTPLLVTACLYYSYCNSRHLQQGVRKSKRPVFSHCQVPETQKTDTRHLSGARAGVCP
CCHPDGLLATMRDLLQYIACFFAFFSAGFLIVATWTDCWMVNADDSLEVSTKCRGLWWEC
VTNAFDGIRTCDEYDSILAEHPLKLVVTRALMITADILAGFGFLTLLLGLDCVKFLPDEP
YIKVRICFVAGATLLIAGTPGIIGSVWYAVDVYVERSTLVLHNIFLGIQYKFGWSCWLGM
AGSLGCFLAGAVLTCCLYLFKDVGPERNYPYSLRKAYSAAGVSMAKSYSAPRTETAKMYA
VDTRV
GenBank ID Protein 5410527
UniProtKB/Swiss-Prot ID Q9Y5I7
UniProtKB/Swiss-Prot Entry Name CLD16_HUMAN
PDB IDs Not Available
GenBank Gene ID AF152101
GeneCard ID CLDN16
GenAtlas ID CLDN16
HGNC ID HGNC:2037
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Simon DB, Lu Y, Choate KA, Velazquez H, Al-Sabban E, Praga M, Casari G, Bettinelli A, Colussi G, Rodriguez-Soriano J, McCredie D, Milford D, Sanjad S, Lifton RP: Paracellin-1, a renal tight junction protein required for paracellular Mg2+ resorption. Science. 1999 Jul 2;285(5424):103-6. [PubMed:10390358 ]
  3. Weber S, Hoffmann K, Jeck N, Saar K, Boeswald M, Kuwertz-Broeking E, Meij II, Knoers NV, Cochat P, Sulakova T, Bonzel KE, Soergel M, Manz F, Schaerer K, Seyberth HW, Reis A, Konrad M: Familial hypomagnesaemia with hypercalciuria and nephrocalcinosis maps to chromosome 3q27 and is associated with mutations in the PCLN-1 gene. Eur J Hum Genet. 2000 Jun;8(6):414-22. [PubMed:10878661 ]
  4. Weber S, Schneider L, Peters M, Misselwitz J, Ronnefarth G, Boswald M, Bonzel KE, Seeman T, Sulakova T, Kuwertz-Broking E, Gregoric A, Palcoux JB, Tasic V, Manz F, Scharer K, Seyberth HW, Konrad M: Novel paracellin-1 mutations in 25 families with familial hypomagnesemia with hypercalciuria and nephrocalcinosis. J Am Soc Nephrol. 2001 Sep;12(9):1872-81. [PubMed:11518780 ]