Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07635
Secondary Accession Numbers
  • 13344
Name Calsyntenin-2
Synonyms
  1. Alc-gamma
  2. Alcadein-gamma
Gene Name CLSTN2
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function May modulate calcium-mediated postsynaptic signals
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Golgi apparatus membrane
  3. Endoplasmic reticulum membrane
  4. Single-pass type I membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:3
Locus 3q23
SNPs CLSTN2
Gene Sequence
>2868 bp
ATGCTGCCTGGGCGGCTGTGCTGGGTGCCGCTCCTGCTGGCGCTGGGCGTGGGGAGCGGC
AGCGGCGGTGGCGGGGACAGCCGGCAGCGCCGCCTCCTCGCGGCTAAAGTCAATAAGCAC
AAGCCATGGATCGAGACTTCATATCATGGAGTCATAACTGAGAACAATGACACAGTCATT
TTGGACCCACCACTGGTAGCCCTGGATAAAGATGCACCGGTTCCTTTTGCAGGGGAAATC
TGTGCGTTCAAGATCCATGGCCAGGAGCTGCCCTTTGAGGCTGTGGTGCTCAACAAGACA
TCAGGAGAGGGCCGGCTCCGTGCCAAGAGCCCCATTGACTGTGAGTTGCAGAAGGAGTAC
ACATTCATCATCCAGGCCTATGACTGTGGTGCTGGGCCCCACGAGACAGCCTGGAAAAAG
TCACACAAGGCCGTGGTCCATATACAGGTGAAGGATGTCAACGAGTTTGCTCCCACCTTC
AAAGAGCCAGCCTACAAGGCTGTTGTGACGGAGGGCAAGATCTATGACAGCATTCTGCAG
GTGGAGGCCATTGACGAGGACTGCTCCCCACAGTACAGCCAGATCTGCAACTATGAAATC
GTCACCACAGATGTGCCTTTTGCCATCGACAGAAATGGCAACATCAGGAACACTGAGAAG
CTGAGCTATGACAAACAACACCAGTATGAGATCCTGGTGACCGCCTACGACTGTGGACAG
AAGCCCGCTGCTCAGGACACCCTGGTGCAGGTGGATGTGAAGCCAGTTTGCAAGCCTGGC
TGGCAAGACTGGACCAAGAGGATTGAGTACCAGCCTGGCTCCGGGAGCATGCCCCTGTTC
CCCAGCATCCACCTGGAGACGTGCGATGGAGCCGTGTCTTCCCTCCAGATCGTCACAGAG
CTGCAGACTAATTACATTGGGAAGGGTTGTGACCGGGAGACCTACTCTGAGAAATCCCTT
CAAAAGTTATGTGGAGCCTCCTCTGGCATCATTGACCTCTTGCCATCCCCTAGCGCTGCC
ACCAACTGGACTGCAGGACTGCTGGTGGACAGCAGTGAGATGATCTTCAAGTTTGACGGC
AGGCAGGGTGCCAAAGTCCCCGATGGGATTGTGCCCAAGAACCTGACCGATCAGTTCACC
ATCACCATGTGGATGAAACACGGCCCCAGCCCTGGTGTGAGAGCCGAGAAGGAAACCATC
CTCTGCAACTCAGACAAAACCGAAATGAACCGGCATCACTATGCCCTGTATGTGCACAAC
TGCCGCCTCGTCTTTCTCTTGCGGAAGGACTTCGACCAGGCTGACACCTTTCGCCCCGCG
GAGTTCCACTGGAAGCTGGATCAGATTTGTGACAAAGAGTGGCACTACTATGTCATCAAT
GTGGAGTTTCCTGTGGTAACCTTATACATGGATGGAGCAACATATGAACCATACCTGGTG
ACCAACGACTGGCCCATTCATCCATCTCACATAGCCATGCAACTCACAGTCGGCGCTTGT
TGGCAAGGAGGAGAAGTCACCAAACCACAGTTTGCTCAGTTCTTTCATGGAAGCCTGGCC
AGTCTCACCATCCGCCCTGGCAAAATGGAAAGCCAGAAGGTGATCTCCTGCCTGCAGGCC
TGCAAGGAAGGGCTGGACATTAATTCCTTGGAAAGCCTTGGCCAAGGAATAAAGTATCAC
TTCAACCCCTCGCAGTCCATCCTGGTGATGGAAGGTGACGACATTGGGAACATTAACCGT
GCTCTCCAGAAAGTCTCCTACATCAACTCCAGGCAGTTCCCAACGGCGGGTGTGCGGCGC
CTCAAAGTATCCTCCAAAGTCCAGTGCTTTGGGGAAGACGTATGCATCAGTATCCCTGAG
GTAGATGCCTATGTGATGGTCCTCCAGGCCATCGAGCCCCGGATCACCCTCCGGGGCACA
GACCACTTCTGGAGACCTGCTGCCCAGTTTGAAAGTGCCAGGGGAGTGACCCTCTTCCCT
GATATCAAGATTGTGAGCACCTTCGCCAAAACCGAAGCCCCCGGGGACGTGAAAACCACA
GACCCCAAATCAGAAGTCTTAGAGGAAATGCTTCATAACTTAGATTTCTGTGACATTTTG
GTGATCGGAGGGGACTTGGACCCAAGGCAGGAGTGCTTGGAGCTCAACCACAGTGAGCTC
CACCAACGACACCTGGATGCCACTAATTCTACTGCAGGCTACTCCATCTACGGTGTGGGC
TCCATGAGCCGCTATGAGCAGGTGCTACATCACATCCGCTACCGCAACTGGCGTCCGGCT
TCCCTTGAGGCCCGGCGTTTCCGGATTAAGTGCTCAGAACTCAATGGGCGCTACACTAGC
AATGAGTTCAACTTGGAGGTCAGCATCCTTCATGAAGACCAAGTCTCAGATAAGGAGCAT
GTCAATCATCTGATTGTGCAGCCTCCCTTCCTCCAGTCTGTCCATCATCCTGAGTCCCGG
AGTAGCATCCAGCACAGTTCAGTGGTCCCAAGCATTGCCACAGTGGTCATCATCATCTCC
GTGTGCATGCTTGTGTTTGTCGTGGCCATGGGTGTGTACCGGGTCCGGATCGCCCACCAG
CACTTCATCCAGGAGACTGAGGCTGCCAAGGAATCTGAGATGGACTGGGACGATTCTGCG
CTGACTATCACAGTCAACCCCATGGAGAAACATGAAGGACCAGGGCATGGGGAAGATGAG
ACTGAGGGAGAAGAGGAGGAAGAAGCCGAGGAAGAAATGAGCTCCAGCAGTGGCTCTGAC
GACAGCGAAGAGGAGGAGGAGGAGGAAGGGATGGGCAGAGGCAGACATGGGCAGAATGGA
GCCAGGCAAGCCCAGCTGGAGTGGGATGACTCCACCCTCCCCTACTAG
Protein Properties
Number of Residues 955
Molecular Weight 107004.9
Theoretical pI 5.07
Pfam Domain Function
Signals
  • 1-20
Transmembrane Regions
  • 832-852
Protein Sequence
>Calsyntenin-2
MLPGRLCWVPLLLALGVGSGSGGGGDSRQRRLLAAKVNKHKPWIETSYHGVITENNDTVI
LDPPLVALDKDAPVPFAGEICAFKIHGQELPFEAVVLNKTSGEGRLRAKSPIDCELQKEY
TFIIQAYDCGAGPHETAWKKSHKAVVHIQVKDVNEFAPTFKEPAYKAVVTEGKIYDSILQ
VEAIDEDCSPQYSQICNYEIVTTDVPFAIDRNGNIRNTEKLSYDKQHQYEILVTAYDCGQ
KPAAQDTLVQVDVKPVCKPGWQDWTKRIEYQPGSGSMPLFPSIHLETCDGAVSSLQIVTE
LQTNYIGKGCDRETYSEKSLQKLCGASSGIIDLLPSPSAATNWTAGLLVDSSEMIFKFDG
RQGAKVPDGIVPKNLTDQFTITMWMKHGPSPGVRAEKETILCNSDKTEMNRHHYALYVHN
CRLVFLLRKDFDQADTFRPAEFHWKLDQICDKEWHYYVINVEFPVVTLYMDGATYEPYLV
TNDWPIHPSHIAMQLTVGACWQGGEVTKPQFAQFFHGSLASLTIRPGKMESQKVISCLQA
CKEGLDINSLESLGQGIKYHFNPSQSILVMEGDDIGNINRALQKVSYINSRQFPTAGVRR
LKVSSKVQCFGEDVCISIPEVDAYVMVLQAIEPRITLRGTDHFWRPAAQFESARGVTLFP
DIKIVSTFAKTEAPGDVKTTDPKSEVLEEMLHNLDFCDILVIGGDLDPRQECLELNHSEL
HQRHLDATNSTAGYSIYGVGSMSRYEQVLHHIRYRNWRPASLEARRFRIKCSELNGRYTS
NEFNLEVSILHEDQVSDKEHVNHLIVQPPFLQSVHHPESRSSIQHSSVVPSIATVVIIIS
VCMLVFVVAMGVYRVRIAHQHFIQETEAAKESEMDWDDSALTITVNPMEKHEGPGHGEDE
TEGEEEEEAEEEMSSSSGSDDSEEEEEEEGMGRGRHGQNGARQAQLEWDDSTLPY
GenBank ID Protein 209364544
UniProtKB/Swiss-Prot ID Q9H4D0
UniProtKB/Swiss-Prot Entry Name CSTN2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_022131.2
GeneCard ID CLSTN2
GenAtlas ID CLSTN2
HGNC ID HGNC:17448
References
General References
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  5. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T: Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. J Biol Chem. 2003 Dec 5;278(49):49448-58. Epub 2003 Sep 12. [PubMed:12972431 ]
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