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Identification
HMDB Protein ID HMDBP07638
Secondary Accession Numbers
  • 13347
Name Cation channel sperm-associated protein 2
Synonyms
  1. CatSper2
Gene Name CATSPER2
Protein Type Unknown
Biological Properties
General Function Involved in ion channel activity
Specific Function Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Multi-pass membrane protein
  2. Cell projection
  3. cilium
  4. flagellum membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 15q15.3
SNPs CATSPER2
Gene Sequence
>1593 bp
ATGGCCGCTTACCAACAAGAAGAGCAGATGCAGCTTCCCCGAGCTGATGCCATTCGTTCA
CGTCTCATCGATACTTTCTCTCTCATTGAGCATTTGCAAGGCTTGAGCCAAGCTGTGCCG
CGGCACACTATCAGGGAGTTACTTGATCCTTCCCGCCAGAAGAAACTTGTATTGGGAGAT
CAACACCAGCTAGTGCGTTTCTCTATAAAGCCTCAGCGTATAGAACAGATTTCACATGCC
CAGAGGCTGTTGAGCAGGCTTCATGTGCGCTGCAGTCAGAGGCCACCTCTTTCTTTGTGG
GCCGGATGGGTCCTTGAGTGTCCTCTCTTCAAAAACTTCATCATCTTCCTGGTCTTTTTG
AATACGATCATATTGATGGTTGAAATAGAATTGCTGGAATCCACAAATACCAAACTATGG
CCATTGAAGCTGACCTTGGAGGTGGCAGCTTGGTTTATCTTGCTTATTTTCATCCTGGAG
ATCCTTCTTAAGTGGCTATCCAACTTTTCTGTTTTCTGGAAGAGTGCCTGGAATGTCTTT
GACTTTGTTGTTACCATGTTGTCCCTGCTTCCCGAGGTTGTGGTATTGGTAGGGGTAACA
GGCCAATCGGTGTGGCTTCAGCTTCTGAGGATCTGCCGGGTGCTGAGGTCTCTCAAACTC
CTTGCACAATTCCGTCAAATTCAAATTATTATTTTGGTCCTGGTCAGGGCCCTCAAGAGC
ATGACCTTCCTCTTGATGTTGCTGCTCATCTTCTTCTACATTTTTGCTGTGACTGGTGTC
TACGTCTTCTCAGAGTACACCCGTTCACCTCGTCAGGACCTGGAGTACCATGTGTTCTTC
TCGGACCTCCCGAATTCCCTGGTAACAGTGTTCATTCTCTTCACCTTGGATCATTGGTAT
GCACTGCTTCAGGACGTCTGGAAGGTGCCTGAAGTCAGTCGCATCTTCAGCAGCATCTAT
TTCATCCTTTGGTTGTTGCTTGGCTCCATTATCTTTCGAAGTATCATAGTAGCCATGATG
GTTACTAACTTTCAGAATATCAGGAAAGAGCTGAATGAGGAGATGGCGCGTCGGGAGGTT
CAGCTCAAAGCTGACATGTTCAAGCGGCAGATCATCCAGAGGAGAAAAAACATGTCACAT
GAAGCACTGACGTCAAGCCATAGCAAAATAGAGGACAGTTCAAGAGGAGCTAGTCAACAA
AGGGAAAGTTTGGACTTATCAGAAGTGTCTGAAGTAGAGTCTAATTATGGTGCCACTGAA
GAGGATTTAATAACATCTGCATCAAAAACAGAAGAGACCTTGTCAAAAAAGAGAGAGTAC
CAGTCTTCCTCCTGTGTCTCCTCCACATCCTCTTCCTATTCTTCCTCTTCTGAATCCAGA
TTTTCTGAATCTATTGGTCGTTTGGACTGGGAGACTCTTGTGCACGAAAATCTGCCCGGG
CTAATGGAAATGGATCAGGATGACCGTGTTTGGCCCAGAGACTCACTCTTCCGATATTTT
GAGTTGCTAGAAAAGCTTCAGTATAACCTAGAGGAACGTAAGAAGTTACAAGAGTTTGCA
GTGCAGGCACTGATGAACTTGGAAGACAAGTAA
Protein Properties
Number of Residues 530
Molecular Weight 62040.6
Theoretical pI 7.33
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 113-133
  • 146-166
  • 179-199
  • 206-226
  • 243-263
  • 321-341
Protein Sequence
>Cation channel sperm-associated protein 2
MAAYQQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGD
QHQLVRFSIKPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFL
NTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVF
DFVVTMLSLLPEVVVLVGVTGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKS
MTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWY
ALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREV
QLKADMFKRQIIQRRKNMSHEALTSSHSKIEDSSRGASQQRESLDLSEVSEVESNYGATE
EDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSSSESRFSESIGRLDWETLVHENLPG
LMEMDQDDRVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQALMNLEDK
GenBank ID Protein 26051223
UniProtKB/Swiss-Prot ID Q96P56
UniProtKB/Swiss-Prot Entry Name CTSR2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_172095.1
GeneCard ID CATSPER2
GenAtlas ID CATSPER2
HGNC ID HGNC:18810
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Zhang D, Chen J, Saraf A, Cassar S, Han P, Rogers JC, Brioni JD, Sullivan JP, Gopalakrishnan M: Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity. J Biol Chem. 2006 Aug 4;281(31):22332-41. Epub 2006 Jun 1. [PubMed:16740636 ]
  3. Li HG, Ding XF, Liao AH, Kong XB, Xiong CL: Expression of CatSper family transcripts in the mouse testis during post-natal development and human ejaculated spermatozoa: relationship to sperm motility. Mol Hum Reprod. 2007 May;13(5):299-306. Epub 2007 Mar 8. [PubMed:17347248 ]
  4. Quill TA, Ren D, Clapham DE, Garbers DL: A voltage-gated ion channel expressed specifically in spermatozoa. Proc Natl Acad Sci U S A. 2001 Oct 23;98(22):12527-31. [PubMed:11675491 ]
  5. Avidan N, Tamary H, Dgany O, Cattan D, Pariente A, Thulliez M, Borot N, Moati L, Barthelme A, Shalmon L, Krasnov T, Ben-Asher E, Olender T, Khen M, Yaniv I, Zaizov R, Shalev H, Delaunay J, Fellous M, Lancet D, Beckmann JS: CATSPER2, a human autosomal nonsyndromic male infertility gene. Eur J Hum Genet. 2003 Jul;11(7):497-502. [PubMed:12825070 ]
  6. Zhang Y, Malekpour M, Al-Madani N, Kahrizi K, Zanganeh M, Lohr NJ, Mohseni M, Mojahedi F, Daneshi A, Najmabadi H, Smith RJ: Sensorineural deafness and male infertility: a contiguous gene deletion syndrome. J Med Genet. 2007 Apr;44(4):233-40. Epub 2006 Nov 10. [PubMed:17098888 ]