Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07650
Secondary Accession Numbers
  • 13359
Name Dentin matrix protein 4
Synonyms
  1. DMP-4
  2. Protein FAM20C
Gene Name FAM20C
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Calcium-binding protein which may play a role in dentin mineralization
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Secreted
Gene Properties
Chromosome Location Chromosome:7
Locus 7p22.3
SNPs FAM20C
Gene Sequence
>1713 bp
ATGGTGTTCCTGGTGGCCTGCGCGCTGCACATCGCCCTGGACCTGCTGCCCAGGCTGGAG
CGACGCGGCGCGCGGCCCTCGGGGGAGCCCGGCTGTTCGTGCGCGCAGCCCGCCGCCGAG
GTGGCCGCGCCCGGCTGGGCCCAGGTTCGGGGCCGCCCCGGGGAGCCCCCGGCCGCCTCC
TCCGCCGCCGGCGACGCGGGCTGGCCCAACAAGCACACGCTCCGCATCCTGCAGGACTTC
AGCTCCGACCCCTCCTCCAACCTCTCGTCCCACTCGCTGGAGAAACTGCCGCCCGCGGCC
GAGCCGGCCGAGCGCGCCTTGCGGGGGCGGGATCCCGGCGCCCTAAGACCCCACGACCCC
GCGCACCGGCCGCTGCTGCGAGACCCCGGCCCGCGTCGGTCCGAGTCGCCCCCCGGCCCC
GGCGGAGACGCCTCCCTCCTGGCCAGGCTGTTCGAGCACCCGCTTTACCGGGTGGCGGTT
CCGCCGCTCACGGAGGAGGACGTCCTGTTCAATGTGAACAGCGACACCAGGCTCAGCCCC
AAAGCGGCGGAGAACCCGGACTGGCCGCATGCGGGTGCTGAAGGTGCAGAATTCCTCTCC
CCCGGGGAGGCGGCCGTGGACTCCTATCCCAACTGGCTCAAGTTCCACATTGGTATCAAC
CGGTACGAGCTGTACTCCAGACACAACCCGGCCATCGAGGCCCTGCTGCACGACCTCAGC
TCCCAGAGGATCACCAGCGTGGCCATGAAGTCGGGGGGCACGCAGCTGAAGCTCATCATG
ACCTTCCAGAATTACGGGCAAGCGCTGTTCAAACCCATGAAACAAACGAGGGAGCAGGAG
ACACCCCCTGACTTTTTTTATTTCTCTGACTACGAGAGGCACAATGCGGAGATTGCTGCC
TTCCACCTGGACAGGATCCTGGACTTCCGCCGGGTCCCTCCCGTGGCCGGCAGGATGGTC
AACATGACCAAGGAGATCCGGGACGTCACACGGGACAAGAAGCTCTGGAGGACCTTCTTC
ATCTCTCCAGCCAACAACATCTGCTTCTACGGCGAGTGTTCCTACTACTGCTCCACGGAG
CACGCCCTGTGCGGGAAGCCAGACCAGATCGAGGGCTCGCTGGCGGCCTTCCTGCCCGAC
CTGTCCCTGGCCAAGAGGAAGACCTGGCGGAACCCTTGGCGGCGTTCCTACCACAAGCGC
AAGAAGGCCGAGTGGGAGGTGGACCCTGACTACTGCGAGGAGGTGAAGCAGACACCGCCC
TACGACAGCAGCCACCGCATCCTGGACGTCATGGACATGACGATCTTCGACTTCCTCATG
GGAAACATGGACCGTCACCACTACGAGACTTTTGAGAAGTTTGGGAATGAAACGTTCATC
ATCCACTTAGACAATGGAAGAGGGTTTGGGAAGTATTCGCACGACGAGCTCTCCATCCTG
GTGCCGCTACAGCAGTGCTGCAGGATCCGGAAGTCCACCTACCTGCGTCTGCAGCTCCTG
GCCAAGGAGGAGTACAAGCTGAGCCTGCTGATGGCCGAGTCTCTGCGGGGGGACCAGGTG
GCACCCGTGCTGTACCAGCCGCACCTGGAGGCCCTGGACCGGCGGCTCCGCGTCGTGCTA
AAGGCCGTCCGGGACTGCGTGGAGAGGAACGGGCTCCACAGCGTGGTGGATGACGACCTG
GACACTGAGCACAGAGCCGCCTCGGCGAGGTAG
Protein Properties
Number of Residues 570
Molecular Weight 64445.4
Theoretical pI 7.21
Pfam Domain Function Not Available
Signals
  • 1-21
Transmembrane Regions
  • None
Protein Sequence
>Dentin matrix protein 4
MVFLVACALHIALDLLPRLERRGARPSGEPGCSCAQPAAEVAAPGWAQVRGRPGEPPAAS
SAAGDAGWPNKHTLRILQDFSSDPSSNLSSHSLEKLPPAAEPAERALRGRDPGALRPHDP
AHRPLLRDPGPRRSESPPGPGGDASLLARLFEHPLYRVAVPPLTEEDVLFNVNSDTRLSP
KAAENPDWPHAGAEGAEFLSPGEAAVDSYPNWLKFHIGINRYELYSRHNPAIEALLHDLS
SQRITSVAMKSGGTQLKLIMTFQNYGQALFKPMKQTREQETPPDFFYFSDYERHNAEIAA
FHLDRILDFRRVPPVAGRMVNMTKEIRDVTRDKKLWRTFFISPANNICFYGECSYYCSTE
HALCGKPDQIEGSLAAFLPDLSLAKRKTWRNPWRRSYHKRKKAEWEVDPDYCEEVKQTPP
YDSSHRILDVMDMTIFDFLMGNMDRHHYETFEKFGNETFIIHLDNGRGFGKYSHDELSIL
VPLQQCCRIRKSTYLRLQLLAKEEYKLSLLMAESLRGDQVAPVLYQPHLEALDRRLRVVL
KAVRDCVERNGLHSVVDDDLDTEHRAASAR
GenBank ID Protein 25304012
UniProtKB/Swiss-Prot ID Q8IXL6
UniProtKB/Swiss-Prot Entry Name DMP4_HUMAN
PDB IDs Not Available
GenBank Gene ID BC040074
GeneCard ID FAM20C
GenAtlas ID FAM20C
HGNC ID HGNC:22140
References
General References
  1. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [PubMed:19159218 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]
  5. Nalbant D, Youn H, Nalbant SI, Sharma S, Cobos E, Beale EG, Du Y, Williams SC: FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells. BMC Genomics. 2005 Jan 27;6:11. [PubMed:15676076 ]
  6. Simpson MA, Hsu R, Keir LS, Hao J, Sivapalan G, Ernst LM, Zackai EH, Al-Gazali LI, Hulskamp G, Kingston HM, Prescott TE, Ion A, Patton MA, Murday V, George A, Crosby AH: Mutations in FAM20C are associated with lethal osteosclerotic bone dysplasia (Raine syndrome), highlighting a crucial molecule in bone development. Am J Hum Genet. 2007 Nov;81(5):906-12. Epub 2007 Sep 14. [PubMed:17924334 ]