Human Metabolome Database: Showing Protein Desmoglein-4 (HMDBP07661)

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Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07661

Secondary Accession Numbers

13370

Name

Desmoglein-4

Synonyms

Cadherin family member 13

Gene Name

DSG4

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein
Cell junction
desmosome

Gene Properties

Chromosome Location

Chromosome:1

Locus

18q12.1

SNPs

DSG4

Gene Sequence

>3123 bp
ATGGATTGGCTCTTCTTCAGAAACATTTGCCTTTTGATCATTCTAATGGTGGTGATGGAA
GTAAACAGTGAATTTATTGTTGAGGTGAAGGAATTTGACATTGAAAATGGCACTACAAAA
TGGCAAACAGTCAGAAGACAAAAGCGGGAGTGGATCAAGTTTGCCGCAGCCTGTCGAGAA
GGAGAGGACAACTCGAAGAGGAACCCCATTGCCAAAATTCGATCAGACTGCGAATCGAAC
CAGAAGATAACATACCGGATTTCTGGAGTAGGGATTGATCGACCACCATATGGGGTATTC
ACCATTAATCCTCGCACTGGGGAAATTAACATCACTTCAGTGGTAGACAGAGAAATAACT
CCACTTTTCTTGATCTATTGCCGGGCTCTGAATTCACGGGGTGAAGATTTAGAAAGGCCT
CTTGAGCTTAGAGTCAAAGTTATGGACATAAATGATAACGCTCCAGTCTTTTCGCAAAGT
GTATACACAGCCAGCATTGAAGAAAATAGTGATGCCAATACATTGGTAGTAAAGTTATGT
GCCACAGATGCAGATGAAGAAAATCATCTGAATTCTAAAATTGCCTACAAGATCGTCTCT
CAGGAGCCATCAGGTGCACCCATGTTCATTCTGAATAGGTACACTGGAGAAGTCTGCACC
ATGTCCAGTTTCTTGGACAGAGAGCAACACAGTATGTACAACCTGGTTGTGAGAGGCTCA
GATCGGGATGGAGCTGCAGATGGACTGTCTTCTGAGTGTGACTGTAGAATCAAGGTTTTA
GACGTCAACGATAATTTCCCCACCTTAGAGAAAACTTCATACTCAGCCAGTATTGAAGAG
AATTGTTTAAGTTCGGAACTGATACGATTACAAGCAATTGATCTTGATGAAGAAGGCACT
GATAACTGGTTGGCTCAATATTTAATTCTCTCTGGAAATGATGGGAATTGGTTCGATATT
CAAACAGATCCACAAACCAATGAAGGCATTTTGAAAGTTGTCAAGATGCTGGATTATGAA
CAAGCACCTAACATTCAGCTTAGTATCGGAGTTAAAAACCAAGCTGATTTTCACTACTCC
GTTGCTTCTCAATTCCAAATGCACCCAACCCCTGTGAGAATTCAAGTTGTTGATGTGAGA
GAAGGACCTGCATTTCATCCAAGTACTATGGCTTTTAGTGTGCGGGAAGGAATAAAAGGA
AGTTCCTTATTGAATTATGTGCTTGGCACATATACAGCCATAGATTTGGACACAGGAAAC
CCTGCAACAGATGTCAGATATATCATAGGGCATGATGCAGGCAGCTGGTTAAAAATTGAT
TCAAGAACTGGTGAGATACAATTTTCTAGAGAATTTGATAAGAAGTCAAAATATATTATC
AATGGGATATACACAGCAGAGATCCTGGCTATAGATGATGGCTCTGGAAAAACAGCTACA
GGAACCATATGTATTGAGGTTCCTGATATCAATGATTATTGTCCAAACATTTTTCCTGAA
AGAAGAACCATCTGCATTGACTCTCCATCAGTCCTTATCTCTGTTAATGAACATTCTTAT
GGGTCTCCGTTTACTTTCTGTGTTGTTGATGAGCCACCAGGAATAGCTGACATGTGGGAT
GTCAGATCAACAAATGCTACCTCGGCAATCCTTACGGCTAAGCAGGTTTTATCTCCAGGA
TTTTATGAAATCCCAATCCTGGTGAAGGACAGCTATAACAGAGCATGTGAATTGGCACAA
ATGGTGCAGTTATATGCCTGTGATTGCGATGACAACCACATGTGCCTGGACTCTGGTGCC
GCGGGCATCTACACAGAGGACATAACTGGTGACACGTATGGGCCTGTCACTGAAGACCAA
GCTGGAGTTTCAAATGTTGGTCTTGGACCAGCAGGGATTGGCATGATGGTTCTGGGCATC
CTGCTACTGATTTTGGCTCCACTCTTGCTGCTCCTGTGTTGCTGCAAACAGAGACAGCCA
GAAGGCCTGGGAACAAGATTTGCTCCTGTGCCTGAGGGCGGAGAAGGAGTGATGCAGTCT
TGGAGAATTGAAGGGGCCCATCCCGAGGACAGGGATGTGTCAAATATATGTGCACCCATG
ACAGCCTCAAATACCCAGGATCGGATGGATTCCTCTGAAATCTACACCAACACCTATGCA
GCCGGGGGCACGGTGGAAGGAGGTGTATCGGGAGTGGAGCTCAACACAGGTATGGGGACA
GCCGTTGGCCTCATGGCCGCAGGGGCCGCAGGAGCCTCAGGGGCCGCAAGGAAGAGGAGC
TCTACCATGGGAACCCTGCGGGACTACGCTGACGCAGACATCAACATGGCTTTCTTGGAC
AGCTACTTCTCGGAGAAAGCGTATGCTTATGCAGATGAAGATGAAGGTCGACCAGCCAAT
GACTGCTTGCTCATTTATGACCACGAGGGAGTCGGGTCTCCCGTAGGCTCTATTGGTTGT
TGCAGTTGGATTGTGGATGACTTAGATGAAAGCTGCATGGAAACTTTAGATCCAAAATTT
AGGACTCTTGCTGAGATCTGCTTAAACACAGAAATTGAACCATTTCCTTCACACCAGGCT
TGTATACCAATCAGTACTGACCTCCCTTTGCTCGGACCTAATTACTTTGTTAATGAATCT
TCAGGATTGACTCCCTCAGAAGTTGAATTCCAAGAAGAAATGGCAGCATCTGAACCCGTG
GTCCATGGGGATATTATTGTGACTGAGACTTACGGTAATGCTGATCCATGTGTGCAACCC
ACTACAATTATTTTTGATCCTCAGCTTGCACCCAATGTTGTAGTAACCGAAGCAGTAATG
GCACCTGTCTATGATATTCAAGGGAATATTTGTGTACCTGCTGAGTTAGCAGATTACAAC
AATGTAATCTATGCTGAGAGAGTACTGGCTAGTCCTGGTGTGCCTGACATGAGCAATAGT
AGCACGACTGAGGGTTGTATGGGACCTGTGATGAGCGGCAATATTTTAGTAGGGCCAGAA
ATTCAAGTGATGCAAATGATGAGTCCAGACCTTCCCATAGGCCAAACCGTTGGCTCCACA
TCCCCCATGACATCTCGACACAGAGTAACACGATACAGTAACATACATTACACCCAACAG
TAA

Protein Properties

Number of Residues

1040

Molecular Weight

113823.1

Theoretical pI

4.17

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_C (PF01049 )

Signals

1-23

Transmembrane Regions

632-652

Protein Sequence

>Desmoglein-4
MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE
GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT
PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC
ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS
DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT
DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS
VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT
GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD
VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP
EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYA
AGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLD
SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKF
RTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPV
VHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYN
NVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGST
SPMTSRHRVTRYSNIHYTQQ

External Links

GenBank ID Protein

29789445

UniProtKB/Swiss-Prot ID

Q86SJ6

UniProtKB/Swiss-Prot Entry Name

DSG4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X, Ahmad W, Aita VM, Gordon D, Uitto J, Whiting D, Ott J, Fischer S, Gilliam TC, Jahoda CA, Morris RJ, Panteleyev AA, Nguyen VT, Christiano AM: Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell. 2003 Apr 18;113(2):249-60. [PubMed:12705872 ]
Whittock NV, Bower C: Genetic evidence for a novel human desmosomal cadherin, desmoglein 4. J Invest Dermatol. 2003 Apr;120(4):523-30. [PubMed:12648213 ]
Rafiq MA, Ansar M, Mahmood S, Haque S, Faiyaz-ul-Haque M, Leal SM, Ahmad W: A recurrent intragenic deletion mutation in DSG4 gene in three Pakistani families with autosomal recessive hypotrichosis. J Invest Dermatol. 2004 Jul;123(1):247-8. [PubMed:15191570 ]