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Identification
HMDB Protein ID HMDBP07677
Secondary Accession Numbers
  • 13386
Name Acylpyruvase FAHD1, mitochondrial
Synonyms
  1. YisK-like protein
  2. Fumarylacetoacetate hydrolase domain-containing protein 1
Gene Name FAHD1
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Probable mitochondrial acylpyruvase which is able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro.
Pathways
  • Tyrosine metabolism
Reactions
A 3-acylpyruvate + Water → a carboxylate + Pyruvic acid details
3-Fumarylpyruvate + Water → Fumaric acid + Pyruvic acid details
GO Classification
Cellular Component
cytosol
mitochondrion
Function
catalytic activity
Molecular Function
metal ion binding
acetylpyruvate hydrolase activity
acylpyruvate hydrolase activity
fumarylpyruvate hydrolase activity
Process
metabolic process
Cellular Location Not Available
Gene Properties
Chromosome Location 16
Locus 16p13.3
SNPs FAHD1
Gene Sequence
>675 bp
ATGGGAATCATGGCAGCATCCAGGCCATTGTCCCGCTTCTGGGAGTGGGGAAAGAACATC
GTCTGCGTGGGGAGGAACTACGCGGACCACGTCAGGGAGATGCGCAGCGCGGTGTTGAGC
GAGCCCGTGCTGTTCCTGAAGCCGTCCACGGCCTACGCGCCCGAGGGCTCGCCCATCCTC
ATGCCCGCGTACACTCGCAACCTGCACCACGAGCTGGAGCTGGGCGTGGTGATGGGCAAG
CGCTGCCGCGCAGTCCCCGAGGCTGCGGCCATGGACTACGTGGGCGGCTATGCCCTGTGC
CTGGATATGACCGCCCGGGACGTGCAGGACGAGTGCAAGAAGAAGGGGCTGCCCTGGACT
CTGGCGAAGAGCTTCACGGCGTCCTGCCCGGTCAGCGCGTTCGTGCCCAAGGAGAAGATC
CCTGACCCTCACAAGCTGAAGCTCTGGCTCAAGGTCAACGGCGAACTCAGACAGGAGGGT
GAGACATCCTCCATGATTTTTTCCATCCCCTACATCATCAGCTATGTTTCTAAGATCATA
ACCTTGGAAGAAGGAGATATTATCTTGACTGGGACGCCAAAGGGAGTTGGACCGGTTAAA
GAAAACGATGAGATCGAGGCTGGCATACACGGGCTGGTCAGTATGACATTTAAAGTGGAA
AAGCCAGAATATTGA
Protein Properties
Number of Residues 224
Molecular Weight 27128.185
Theoretical pI 7.689
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Fumarylacetoacetate hydrolase domain-containing protein 1
MGIMAASRPLSRFWEWGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPIL
MPAYTRNLHHELELGVVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWT
LAKSFTASCPVSAFVPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKII
TLEEGDIILTGTPKGVGPVKENDEIEAGIHGLVSMTFKVEKPEY
GenBank ID Protein 13654274
UniProtKB/Swiss-Prot ID Q6P587
UniProtKB/Swiss-Prot Entry Name FAHD1_HUMAN
PDB IDs
GenBank Gene ID NM_031208.3
GeneCard ID FAHD1
GenAtlas ID FAHD1
HGNC ID HGNC:14169
References
General References
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  3. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
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  6. Manjasetty BA, Niesen FH, Delbruck H, Gotz F, Sievert V, Bussow K, Behlke J, Heinemann U: X-ray structure of fumarylacetoacetate hydrolase family member Homo sapiens FLJ36880. Biol Chem. 2004 Oct;385(10):935-42. [PubMed:15551868 ]