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Showing Protein Homer protein homolog 1 (HMDBP07732)
Identification | |
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HMDB Protein ID | HMDBP07732 |
Secondary Accession Numbers |
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Name | Homer protein homolog 1 |
Synonyms |
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Gene Name | HOMER1 |
Protein Type | Unknown |
Biological Properties | |
General Function | Cell cycle control, cell division, chromosome partitioning |
Specific Function | Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development |
Pathways | Not Available |
Reactions | Not Available |
GO Classification | Not Available |
Cellular Location |
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Gene Properties | |
Chromosome Location | Chromosome:5 |
Locus | 5q14.2 |
SNPs | HOMER1 |
Gene Sequence |
>1065 bp ATGGGGGAGCAGCCGATTTTCAGCACTCGAGCTCATGTCTTCCAAATTGACCCAAACACA AAGAAGAACTGGGTACCCACCAGCAAGCATGCAGTTACTGTGTCTTATTTCTATGACAGC ACAAGAAATGTGTATAGGATAATCAGTTTAGATGGCTCAAAGGCAATAATAAATAGTACC ATCACCCCAAACATGACATTTACTAAAACATCTCAGAAGTTTGGCCAGTGGGCTGATAGC CGGGCAAACACCGTTTATGGATTGGGATTCTCCTCTGAGCATCATCTTTCGAAATTTGCA GAAAAGTTTCAGGAATTTAAAGAAGCTGCTCGACTAGCAAAGGAAAAATCACAAGAGAAG ATGGAACTTACCAGTACACCTTCACAGGAATCCGCAGGCGGGGATCTTCAGTCTCCTTTA ACACCGGAAAGTATCAACGGGACAGATGATGAAAGAACACCTGATGTGACACAGAACTCA GAGCCAAGGGCTGAACCAACTCAGAATGCATTGCCATTTTCACATAGTTCAGCAATCAGC AAACATTGGGAGGCTGAACTGGCTACCCTCAAAGGAAATAATGCCAAACTCACTGCAGCC CTGCTGGAGTCCACTGCCAATGTGAAACAATGGAAACAGCAACTTGCTGCCTATCAAGAG GAAGCAGAACGTCTGCACAAGCGGGTGACTGAACTTGAATGTGTTAGTAGCCAAGCAAAT GCAGTACATACTCATAAGACAGAATTAAATCAGACAATACAAGAACTGGAAGAGACACTG AAACTGAAGGAAGAGGAAATAGAAAGGTTAAAACAAGAAATTGATAATGCCAGAGAACTA CAAGAACAGAGGGATTCTTTGACTCAGAAACTACAGGAAGTAGAAATTCGGAACAAAGAC CTGGAGGGACAACTGTCTGACTTAGAGCAACGTCTGGAGAAAAGTCAGAATGAACAAGAA GCTTTTCGCAATAACCTGAAGACACTCTTAGAAATTCTGGATGGAAAGATATTTGAACTA ACAGAATTACGAGATAACTTGGCCAAGCTACTAGAATGCAGCTAA |
Protein Properties | |
Number of Residues | 354 |
Molecular Weight | 40276.5 |
Theoretical pI | 5.14 |
Pfam Domain Function |
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Signals |
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Transmembrane Regions |
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Protein Sequence |
>Homer protein homolog 1 MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAIS KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN AVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD LEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS |
External Links | |
GenBank ID Protein | 3834615 |
UniProtKB/Swiss-Prot ID | Q86YM7 |
UniProtKB/Swiss-Prot Entry Name | HOME1_HUMAN |
PDB IDs | |
GenBank Gene ID | AF093262 |
GeneCard ID | HOMER1 |
GenAtlas ID | HOMER1 |
HGNC ID | HGNC:17512 |
References | |
General References |
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