Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07775
Secondary Accession Numbers
  • 13484
Name Lck-interacting transmembrane adapter 1
Synonyms
  1. Lck-interacting membrane protein
  2. Lck-interacting molecule
Gene Name LIME1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cell membrane
  2. Single-pass type III membrane protein
Gene Properties
Chromosome Location Chromosome:2
Locus 20q13.3
SNPs LIME1
Gene Sequence
>888 bp
ATGGGGCTGCCAGTGTCCTGGGCCCCTCCTGCCCTCTGGGTTCTAGGGTGCTGCGCCCTG
CTCCTCTCGCTGTGGGCGCTGTGCACAGCCTGCCGCAGGCCCGAGGACGCTGTAGCCCCC
AGGAAGAGGGCGCGGAGGCAGCGGGCGAGGCTGCAGGGCAGTGCGACGGCGGCGGAAGCG
TCCCTACTGAGGCGGACCCACCTCTGCTCCCTCAGCAAGTCGGACACCAGACTGCACGAG
CTGCACCGGGGCCCGCGCAGCAGCAGGGCCCTGCGGCCTGCCAGCATGGATCTCCTGCGC
CCACACTGGCTGGAGGTGTCCAGGGACATCACCGGACCGCAGGCAGCCCCCTCTGCCTTC
CCACACCAGGAGCTGCCCCGGGCTCTGCCGGCAGCTGCAGCCACCGCAGGGTGCGCTGGC
CTCGAGGCCACCTATTCCAACGTGGGGCTGGCGGCCCTTCCCGGGGTCAGCCTGGCGGCC
AGCCCTGTGGTGGCCGAGTATGCCCGCGTCCAGAAGCGCAAAGGGACCCATCGCAGTCCC
CAAGAGCCACAGCAGGGGAAGACTGAGGTGACCCCGGCCGCTCAGGTGGACGTCCTGTAC
TCCAGGGTCTGCAAGCCTAAAAGGAGGGACCCAGGACCCACCACAGACCCGCTGGACCCC
AAGGGCCAGGGAGCGATTCTGGCCCTGGCGGGTGACCTGGCCTACCAGACCCTCCCGCTC
AGGGCCCTGGATGTGGGCAGCGGCCCCCTGGAAAACGTGTATGAGAGCATCCGGGAGCTG
GGGGACCCTGCTGGCAGGAGCAGCACGTGCGGGGCTGGGACGCCCCCTGCTTCCAGCTGC
CCCAGCCTAGGGAGGGGCTGGAGACCCCTCCCTGCCTCCCTGCCCTGA
Protein Properties
Number of Residues 295
Molecular Weight 31287.4
Theoretical pI 9.99
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • 7-27
Protein Sequence
>Lck-interacting transmembrane adapter 1
MGLPVSWAPPALWVLGCCALLLSLWALCTACRRPEDAVAPRKRARRQRARLQGSATAAEA
SLLRRTHLCSLSKSDTRLHELHRGPRSSRALRPASMDLLRPHWLEVSRDITGPQAAPSAF
PHQELPRALPAAAATAGCAGLEATYSNVGLAALPGVSLAASPVVAEYARVQKRKGTHRSP
QEPQQGKTEVTPAAQVDVLYSRVCKPKRRDPGPTTDPLDPKGQGAILALAGDLAYQTLPL
RALDVDSGPLENVYESIRELGDPAGRSSTCGAGTPPASSCPSLGRGWRPLPASLP
GenBank ID Protein 7020485
UniProtKB/Swiss-Prot ID Q9H400
UniProtKB/Swiss-Prot Entry Name LIME1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK000413
GeneCard ID LIME1
GenAtlas ID LIME1
HGNC ID HGNC:26016
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  4. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, Nardone J, Lee K, Reeves C, Li Y, Hu Y, Tan Z, Stokes M, Sullivan L, Mitchell J, Wetzel R, Macneill J, Ren JM, Yuan J, Bakalarski CE, Villen J, Kornhauser JM, Smith B, Li D, Zhou X, Gygi SP, Gu TL, Polakiewicz RD, Rush J, Comb MJ: Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell. 2007 Dec 14;131(6):1190-203. [PubMed:18083107 ]
  5. Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J: Large-scale cDNA transfection screening for genes related to cancer development and progression. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15724-9. Epub 2004 Oct 21. [PubMed:15498874 ]
  6. Brdickova N, Brdicka T, Angelisova P, Horvath O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsi V: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med. 2003 Nov 17;198(10):1453-62. Epub 2003 Nov 10. [PubMed:14610046 ]
  7. Hur EM, Son M, Lee OH, Choi YB, Park C, Lee H, Yun Y: LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation. J Exp Med. 2003 Nov 17;198(10):1463-73. Epub 2003 Nov 10. [PubMed:14610044 ]
  8. Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rudiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsi V: Transmembrane adaptor molecules: a new category of lymphoid-cell markers. Blood. 2006 Jan 1;107(1):213-21. Epub 2005 Sep 13. [PubMed:16160011 ]