Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07787
Secondary Accession Numbers
  • 13496
  • HMDBP10869
Name Leukotriene B4 receptor 2
Synonyms
  1. LTB4 receptor JULF2
  2. LTB4-R 2
  3. LTB4-R2
  4. Leukotriene B4 receptor BLT2
  5. Seven transmembrane receptor BLTR2
  6. SubName: HCG2043009
Gene Name LTB4R2
Protein Type Unknown
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
receptor activity
transmembrane receptor activity
molecular transducer activity
signal transducer activity
leukotriene receptor activity
g-protein coupled receptor activity
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 14q11.2-q12
SNPs LTB4R2
Gene Sequence
>1170 bp
ATGGCACCTTCTCATCGGGCATCACAGGTGGGGTTTTGCCCCACCCCTGAACGCCCTCTG
TGGCGCCTTCCACCCACCTGTAGGCCCAGAAGGATGTCGGTCTGCTACCGTCCCCCAGGG
AACGAGACACTGCTGAGCTGGAAGACTTCGCGGGCCACAGGCACAGCCTTCCTGCTGCTG
GCGGCGCTGCTGGGGCTGCCTGGCAACGGCTTCGTGGTGTGGAGCTTGGCGGGCTGGCGG
CCTGCACGGGGGCGACCGCTGGCGGCCACGCTTGTGCTGCACCTGGCGCTGGCCGACGGC
GCGGTGCTGCTGCTCACGCCGCTCTTTGTGGCCTTCCTGACCCGGCAGGCCTGGCCGCTG
GGCCAGGCGGGCTGCAAGGCGGTGTACTACGTGTGCGCGCTCAGCATGTACGCCAGCGTG
CTGCTCACCGGCCTGCTCAGCCTGCAGCGCTGCCTCGCAGTCACCCGCCCCTTCCTGGCG
CCTCGGCTGCGCAGCCCGGCCCTGGCCCGCCGCCTGCTGCTGGCGGTCTGGCTGGCCGCC
CTGTTGCTCGCCGTCCCGGCCGCCGTCTACCGCCACCTGTGGAGGGACCGCGTATGCCAG
CTGTGCCACCCGTCGCCGGTCCACGCCGCCGCCCACCTGAGCCTGGAGACTCTGACCGCT
TTCGTGCTTCCTTTCGGGCTGATGCTCGGCTGCTACAGCGTGACGCTGGCACGGCTGCGG
GGCGCCCGCTGGGGCTCCGGGCGGCACGGGGCGCGGGTGGGCCGGCTGGTGAGCGCCATC
GTGCTTGCCTTCGGCTTGCTCTGGGCCCCCTACCACGCAGTCAACCTTCTGCAGGCGGTC
GCAGCGCTGGCTCCACCGGAAGGGGCCTTGGCGAAGCTGGGCGGAGCCGGCCAGGCGGCG
CGAGCGGGAACTACGGCCTTGGCCTTCTTCAGTTCTAGCGTCAACCCGGTGCTCTACGTC
TTCACCGCTGGAGATCTGCTGCCCCGGGCAGGTCCCCGTTTCCTCACGCGGCTCTTCGAA
GGCTCTGGGGAGGCCCGAGGGGGCGGCCGCTCTAGGGAAGGGACCATGGAGCTCCGAACT
ACCCCTCAGCTGAAAGTGGTGGGGCAGGGCCGCGGCAATGGAGACCCGGGGGGTGGGATG
GAGAAGGACGGTCCGGAATGGGACCTTTGA
Protein Properties
Number of Residues 389
Molecular Weight 41524.3
Theoretical pI 11.49
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 56-76
  • 92-112
  • 128-148
  • 173-193
  • 217-237
  • 257-277
  • 307-327
Protein Sequence
>Leukotriene B4 receptor 2
MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLL
AALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPL
GQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAA
LLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLR
GARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAA
RAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRT
TPQLKVVGQGRGNGDPGGGMEKDGPEWDL
GenBank ID Protein 57157113
UniProtKB/Swiss-Prot ID Q9NPC1
UniProtKB/Swiss-Prot Entry Name LT4R2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF277230
GeneCard ID LTB4R2
GenAtlas ID LTB4R2
HGNC ID HGNC:19260
References
General References
  1. Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S: Identification of G protein-coupled receptor genes from the human genome sequence. FEBS Lett. 2002 Jun 5;520(1-3):97-101. [PubMed:12044878 ]
  2. Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, Smith HO, Yandell M, Evans CA, Holt RA, Gocayne JD, Amanatides P, Ballew RM, Huson DH, Wortman JR, Zhang Q, Kodira CD, Zheng XH, Chen L, Skupski M, Subramanian G, Thomas PD, Zhang J, Gabor Miklos GL, Nelson C, Broder S, Clark AG, Nadeau J, McKusick VA, Zinder N, Levine AJ, Roberts RJ, Simon M, Slayman C, Hunkapiller M, Bolanos R, Delcher A, Dew I, Fasulo D, Flanigan M, Florea L, Halpern A, Hannenhalli S, Kravitz S, Levy S, Mobarry C, Reinert K, Remington K, Abu-Threideh J, Beasley E, Biddick K, Bonazzi V, Brandon R, Cargill M, Chandramouliswaran I, Charlab R, Chaturvedi K, Deng Z, Di Francesco V, Dunn P, Eilbeck K, Evangelista C, Gabrielian AE, Gan W, Ge W, Gong F, Gu Z, Guan P, Heiman TJ, Higgins ME, Ji RR, Ke Z, Ketchum KA, Lai Z, Lei Y, Li Z, Li J, Liang Y, Lin X, Lu F, Merkulov GV, Milshina N, Moore HM, Naik AK, Narayan VA, Neelam B, Nusskern D, Rusch DB, Salzberg S, Shao W, Shue B, Sun J, Wang Z, Wang A, Wang X, Wang J, Wei M, Wides R, Xiao C, Yan C, Yao A, Ye J, Zhan M, Zhang W, Zhang H, Zhao Q, Zheng L, Zhong F, Zhong W, Zhu S, Zhao S, Gilbert D, Baumhueter S, Spier G, Carter C, Cravchik A, Woodage T, Ali F, An H, Awe A, Baldwin D, Baden H, Barnstead M, Barrow I, Beeson K, Busam D, Carver A, Center A, Cheng ML, Curry L, Danaher S, Davenport L, Desilets R, Dietz S, Dodson K, Doup L, Ferriera S, Garg N, Gluecksmann A, Hart B, Haynes J, Haynes C, Heiner C, Hladun S, Hostin D, Houck J, Howland T, Ibegwam C, Johnson J, Kalush F, Kline L, Koduru S, Love A, Mann F, May D, McCawley S, McIntosh T, McMullen I, Moy M, Moy L, Murphy B, Nelson K, Pfannkoch C, Pratts E, Puri V, Qureshi H, Reardon M, Rodriguez R, Rogers YH, Romblad D, Ruhfel B, Scott R, Sitter C, Smallwood M, Stewart E, Strong R, Suh E, Thomas R, Tint NN, Tse S, Vech C, Wang G, Wetter J, Williams S, Williams M, Windsor S, Winn-Deen E, Wolfe K, Zaveri J, Zaveri K, Abril JF, Guigo R, Campbell MJ, Sjolander KV, Karlak B, Kejariwal A, Mi H, Lazareva B, Hatton T, Narechania A, Diemer K, Muruganujan A, Guo N, Sato S, Bafna V, Istrail S, Lippert R, Schwartz R, Walenz B, Yooseph S, Allen D, Basu A, Baxendale J, Blick L, Caminha M, Carnes-Stine J, Caulk P, Chiang YH, Coyne M, Dahlke C, Mays A, Dombroski M, Donnelly M, Ely D, Esparham S, Fosler C, Gire H, Glanowski S, Glasser K, Glodek A, Gorokhov M, Graham K, Gropman B, Harris M, Heil J, Henderson S, Hoover J, Jennings D, Jordan C, Jordan J, Kasha J, Kagan L, Kraft C, Levitsky A, Lewis M, Liu X, Lopez J, Ma D, Majoros W, McDaniel J, Murphy S, Newman M, Nguyen T, Nguyen N, Nodell M, Pan S, Peck J, Peterson M, Rowe W, Sanders R, Scott J, Simpson M, Smith T, Sprague A, Stockwell T, Turner R, Venter E, Wang M, Wen M, Wu D, Wu M, Xia A, Zandieh A, Zhu X: The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304-51. [PubMed:11181995 ]
  3. Tryselius Y, Nilsson NE, Kotarsky K, Olde B, Owman C: Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. Biochem Biophys Res Commun. 2000 Aug 2;274(2):377-82. [PubMed:10913346 ]
  4. Yokomizo T, Kato K, Terawaki K, Izumi T, Shimizu T: A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000 Aug 7;192(3):421-32. [PubMed:10934230 ]
  5. Wang S, Gustafson E, Pang L, Qiao X, Behan J, Maguire M, Bayne M, Laz T: A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J Biol Chem. 2000 Dec 29;275(52):40686-94. [PubMed:11006272 ]
  6. Kamohara M, Takasaki J, Matsumoto M, Saito T, Ohishi T, Ishii H, Furuichi K: Molecular cloning and characterization of another leukotriene B4 receptor. J Biol Chem. 2000 Sep 1;275(35):27000-4. [PubMed:10889186 ]