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Identification
HMDB Protein ID HMDBP07846
Secondary Accession Numbers
  • 13555
Name NADPH oxidase 5
Synonyms Not Available
Gene Name NOX5
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
electron carrier activity
iron ion binding
oxidoreductase activity
fad or fadh2 binding
calcium ion binding
Process
metabolic process
oxidation reduction
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein (Potential)
Gene Properties
Chromosome Location Chromosome:1
Locus 15q23
SNPs NOX5
Gene Sequence
>2298 bp
ATGAACACATCTGGAGACCCAGCCCAGACGGGCCCTGAAGGCTGTAGAGGCACCATGAGT
GCCGAGGAGGATGCCAGGTGGCTCCGGTGGGTGACTCAGCAGTTTAAGACCATTGCAGGA
GAAGATGGGGAGATCAGCCTGCAAGAATTCAAAGCAGCTCTGCATGTGAAAGAGTCCTTC
TTTGCAGAGCGATTCTTTGCCCTATTTGACTCCGATAGAAGTGGCACCATCACCCTCCAG
GAGCTGCAGGAGGCACTGACCCTGCTCATCCATGGCAGCCCCATGGACAAACTCAAATTC
CTCTTCCAGGTGTATGACATCGATGTGTGTGCACGGCAGGGGGCGTCTGCAGGTACAGAG
TGGGGTGCTGGGGCAGGCCCGCACTGGGCTTCATCCCCACTCGGGACAGGCAGTGGCTCC
ATTGACCCGGATGAGCTGCGCACTGTGCTGCAGTCGTGTCTGCGCGAGAGCGCCATCTCG
CTGCCTGACGAGAAGCTGGACCAGCTGACGCTGGCGCTCTTCGAATCGGCCGACGCGGAC
GGCAACGGGGCCATCACCTTCGAGGAGCTCCGGGACGAGCTGCAGCGCTTCCCCGGAGTC
ATGGAGAACCTGACCATCAGCGCTGCCCACTGGCTGACGGCCCCCGCCCCCCGCCCACGC
CCGCGCCGGCCGCGCCAGCTGACCCGCGCCTACTGGCACAACCACCGCAGCCAGCTGTTC
TGCCTGGCCACCTATGCAGGCCTCCACGTGCTGCTCTTCGGGCTGGCGGCCAGCGCGCAC
CGGGACCTCGGCGCCAGCGTCATGGTGGCCAAGGGCTGCGGCCAGTGCCTCAACTTCGAC
TGCAGCTTCATCGCGGTGCTGATGCTCAGACGCTGCCTCACCTGGCTGCGGGCCACGTGG
CTGGCTCAAGTCCTACCACTGGACCAGAACATCCAGTTCCACCAGCTTATGGGCTACGTG
GTAGTGGGGCTGTCCCTCGTGCACACCGTGGCTCACACTGTGAACTTTGTACTCCAGGCT
CAGGCGGAGGCCAGCCCTTTCCAGTTCTGGGAGCTGCTGCTCACCACGAGGCCTGGCATT
GGCTGGGTACACGGTTCGGCCTCCCCGACAGGTGTCGCTCTGCTGCTGCTGCTCCTCCTC
ATGTTCATCTGCTCCAGTTCCTGCATCCGCAGGAGTGGCCACTTTGAGGTGTTCTATTGG
ACTCACCTGTCCTACCTCCTCGTGTGGCTTCTGCTCATCTTTCATGGGCCCAACTTCTGG
AAGTGGCTGCTGGTGCCTGGAATCTTGTTTTTCCTGGAGAAGGCCATCGGACTGGCAGTG
TCCCGCATGGCAGCCGTGTGCATCATGGAAGTCAACCTCCTCCCCTCCAAGGTCACTCAT
CTCCTCATCAAGCGGCCCCCTTTTTTTCACTATAGACCTGGTGACTACTTGTATCTGAAC
ATCCCCACCATTGCTCGCTATGAGTGGCACCCCTTCACCATCAGCAGTGCTCCTGAGCAG
AAAGACACTATCTGGCTGCACATTCGGTCCCAAGGCCAGTGGACAAACAGGCTGTATGAG
TCCTTCAAGGCATCAGACCCACTGGGCCGTGGTTCTAAGAGGCTGTCGAGGAGTGTGACA
ATGAGAAAGAGTCAAAGGTCGTCCAAGGGCTCTGAGATACTTTTGGAGAAACACAAATTC
TGTAACATCAAGTGCTACATCGATGGGCCTTATGGGACCCCCACCCGCAGGATCTTTGCC
TCTGAGCATGCCGTGCTCATCGGGGCAGGCATCGGCATCACCCCCTTTGCTTCCATTCTG
CAGAGTATCATGTACAGGCACCAGAAAAGAAAGCATACTTGCCCCAGCTGCCAGCACTCC
TGGATCGAAGGTGTCCAAGACAACATGAAGCTCCATAAGGTGGACTTTATCTGGATCAAC
AGAGACCAGCGGTCTTTCGAGTGGTTTGTGAGCCTGCTGACTAAACTGGAGATGGACCAG
GCCGAGGAGGCTCAATACGGCCGCTTCCTGGAGCTGCATATGTACATGACATCTGCACTG
GGCAAGAATGACATGAAGGCCATTGGCCTGCAGATGGCCCTTGACCTCCTGGCCAACAAG
GAGAAGAAAGACTCCATCACGGGGCTGCAGACGCGCACCCAGCCTGGGCGGCCTGACTGG
AGCAAGGTGTTCCAGAAAGTGGCTGCTGAGAAGAAGGGCAAGGTGCAGGTCTTCTTCTGT
GGCTCCCCAGCTCTGGCCAAGGTGCTGAAGGGCCATTGTGAGAAGTTCGGCTTCAGATTT
TTCCAAGAGAATTTCTAG
Protein Properties
Number of Residues 765
Molecular Weight 86438.1
Theoretical pI 8.72
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 239-259
  • 267-289
  • 318-338
  • 363-383
  • 395-417
  • 435-455
  • 584-604
Protein Sequence
>NADPH oxidase 5
MNTSGDPAQTGPEGCRGTMSAEEDARWLRWVTQQFKTIAGEDGEISLQEFKAALHVKESF
FAERFFALFDSDRSGTITLQELQEALTLLIHGSPMDKLKFLFQVYDIDVCARQGASAGTE
WGAGAGPHWASSPLGTGSGSIDPDELRTVLQSCLRESAISLPDEKLDQLTLALFESADAD
GNGAITFEELRDELQRFPGVMENLTISAAHWLTAPAPRPRPRRPRQLTRAYWHNHRSQLF
CLATYAGLHVLLFGLAASAHRDLGASVMVAKGCGQCLNFDCSFIAVLMLRRCLTWLRATW
LAQVLPLDQNIQFHQLMGYVVVGLSLVHTVAHTVNFVLQAQAEASPFQFWELLLTTRPGI
GWVHGSASPTGVALLLLLLLMFICSSSCIRRSGHFEVFYWTHLSYLLVWLLLIFHGPNFW
KWLLVPGILFFLEKAIGLAVSRMAAVCIMEVNLLPSKVTHLLIKRPPFFHYRPGDYLYLN
IPTIARYEWHPFTISSAPEQKDTIWLHIRSQGQWTNRLYESFKASDPLGRGSKRLSRSVT
MRKSQRSSKGSEILLEKHKFCNIKCYIDGPYGTPTRRIFASEHAVLIGAGIGITPFASIL
QSIMYRHQKRKHTCPSCQHSWIEGVQDNMKLHKVDFIWINRDQRSFEWFVSLLTKLEMDQ
AEEAQYGRFLELHMYMTSALGKNDMKAIGLQMALDLLANKEKKDSITGLQTRTQPGRPDW
SKVFQKVAAEKKGKVQVFFCGSPALAKVLKGHCEKFGFRFFQENF
GenBank ID Protein 296278229
UniProtKB/Swiss-Prot ID Q96PH1
UniProtKB/Swiss-Prot Entry Name NOX5_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_024505.3
GeneCard ID NOX5
GenAtlas ID NOX5
HGNC ID HGNC:14874
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Banfi B, Molnar G, Maturana A, Steger K, Hegedus B, Demaurex N, Krause KH: A Ca(2+)-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem. 2001 Oct 5;276(40):37594-601. Epub 2001 Aug 1. [PubMed:11483596 ]
  3. Kawahara T, Ritsick D, Cheng G, Lambeth JD: Point mutations in the proline-rich region of p22phox are dominant inhibitors of Nox1- and Nox2-dependent reactive oxygen generation. J Biol Chem. 2005 Sep 9;280(36):31859-69. Epub 2005 Jun 30. [PubMed:15994299 ]
  4. Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD: Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene. 2001 May 16;269(1-2):131-40. [PubMed:11376945 ]
  5. Brar SS, Corbin Z, Kennedy TP, Hemendinger R, Thornton L, Bommarius B, Arnold RS, Whorton AR, Sturrock AB, Huecksteadt TP, Quinn MT, Krenitsky K, Ardie KG, Lambeth JD, Hoidal JR: NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells. Am J Physiol Cell Physiol. 2003 Aug;285(2):C353-69. Epub 2003 Apr 9. [PubMed:12686516 ]
  6. Banfi B, Tirone F, Durussel I, Knisz J, Moskwa P, Molnar GZ, Krause KH, Cox JA: Mechanism of Ca2+ activation of the NADPH oxidase 5 (NOX5). J Biol Chem. 2004 Apr 30;279(18):18583-91. Epub 2004 Feb 24. [PubMed:14982937 ]
  7. Cucoranu I, Clempus R, Dikalova A, Phelan PJ, Ariyan S, Dikalov S, Sorescu D: NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts. Circ Res. 2005 Oct 28;97(9):900-7. Epub 2005 Sep 22. [PubMed:16179589 ]
  8. Kamiguti AS, Serrander L, Lin K, Harris RJ, Cawley JC, Allsup DJ, Slupsky JR, Krause KH, Zuzel M: Expression and activity of NOX5 in the circulating malignant B cells of hairy cell leukemia. J Immunol. 2005 Dec 15;175(12):8424-30. [PubMed:16339585 ]