Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07874
Secondary Accession Numbers
  • 13585
Name Protocadherin-19
Synonyms Not Available
Gene Name PCDH19
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs PCDH19
Gene Sequence
>3447 bp
ATGGAGTCGCTCCTGCTGCCGGTGCTGCTGCTGCTGGCCATACTGTGGACGCAGGCTGCC
GCCCTCATTAATCTCAAGTACTCGGTAGAAGAGGAGCAGCGCGCCGGGACGGTGATTGCC
AACGTGGCCAAAGACGCGCGAGAGGCGGGCTTCGCGCTGGACCCCCGGCAGGCTTCAGCC
TTTCGCGTGGTGTCCAACTCGGCTCCACACCTAGTGGACATCAATCCCAGCTCTGGCCTG
CTGGTCACCAAGCAGAAGATTGACCGTGATCTGCTGTGCCGCCAGAGCCCCAAGTGCATC
ATCTCGCTCGAGGTCATGTCCAGCTCAATGGAAATCTGCGTGATAAAGGTGGAGATCAAG
GACCTGAACGACAATGCGCCCAGTTTCCCGGCAGCACAGATCGAGCTGGAGATCTCGGAG
GCAGCCAGCCCTGGCACGCGCATCCCGCTGGACAGCGCTTACGATCCAGACTCAGGAAGC
TTTGGCGTGCAGACTTACGAGCTCACGCCCAACGAGCTGTTCGGCCTGGAGATCAAGACG
CGCGGCGACGGCTCCCGCTTTGCCGAACTCGTGGTGGAAAAGAGCCTGGACCGCGAGACG
CAGTCGCACTACAGCTTCCGAATCACTGCGCTAGACGGTGGCGACCCGCCGCGCCTGGGC
ACCGTTGGCCTTAGTATCAAGGTGACCGACTCCAATGACAACAACCCGGTGTTTAGCGAG
TCCACCTACGCGGTGAGCGTGCCAGAAAACTCGCCTCCCAACACACCCGTCATCCGCCTC
AACGCCAGCGATCCAGACGAGGGCACCAACGGCCAGGTGGTCTACTCCTTCTATGGCTAC
GTCAACGACCGCACGCGCGAGCTCTTTCAGATCGACCCGCACAGTGGCCTGGTCACTGTC
ACTGGCGCTTTAGACTACGAAGAGGGGCACGTGTACGAACTGGACGTGCAGGCTAAGGAC
TTGGGGCCCAATTCCATCCCGGCACACTGCAAGGTCACCGTCAGCGTGCTGGACACCAAT
GACAATCCGCCGGTCATCAACCTGCTGTCAGTCAACAGTGAGCTTGTGGAGGTCAGCGAG
AGCGCCCCCCCGGGCTACGTGATCGCCTTGGTGCGGGTGTCTGATCGCGACTCAGGCCTC
AATGGACGTGTGCAGTGCCGTTTGCTGGGCAATGTGCCCTTTCGACTGCAGGAATATGAG
AGCTTCTCCACTATTCTGGTGGACGGACGGCTGGACCGCGAGCAGCACGACCAATACAAC
CTCACAATTCAGGCACGCGACGGCGGCGTGCCCATGCTGCAGAGTGCCAAGTCCTTTACC
GTGCTCATCACTGACGAAAATGACAACCACCCGCACTTTTCCAAGCCCTACTACCAGGTC
ATTGTGCAGGAGAACAACACGCCTGGCGCCTATCTGCTCTCTGTGTCTGCTCGCGACCCC
GACCTGGGTCTCAACGGCAGTGTCTCCTACCAGATCGTGCCGTCGCAGGTGCGGGACATG
CCTGTCTTCACCTATGTCTCCATCAATCCCAACTCAGGCGACATCTACGCGCTGCGATCC
TTTAACCACGAGCAGACCAAGGCGTTCGAATTCAAGGTGCTGGCCAAGGACGGCGGCCTT
CCCTCACTGCAAAGCAACGCTACGGTGCGGGTCATCATCCTCGACGTCAACGACAACACC
CCGGTCATCACAGCCCCACCTCTGATTAACGGCACTGCCGAGGTCTACATACCCCGCAAC
TCTGGCATAGGCTACCTGGTGACTGTTGTCAAGGCAGAAGACTACGATGAGGGCGAAAAT
GGCCGAGTCACCTACGACATGACCGAGGGCGACCGCGGCTTCTTTGAAATAGACCAGGTC
AATGGCGAAGTCAGAACCACCCGCACCTTCGGGGAGAGCTCCAAGTCCTCCTATGAGCTT
ATCGTGGTGGCTCACGACCACGGCAAGACATCTCTCTCTGCCTCTGCTCTCGTCCTAATC
TACTTGTCCCCTGCTCTCGATGCCCAAGAGTCAATGGGCTCTGTGAACTTGTCCTTGATT
TTCATTATTGCCCTGGGCTCCATTGCGGGCATCCTCTTTGTAACTATGATCTTCGTGGCA
ATCAAGTGCAAGCGAGACAACAAAGAGATCCGGACCTACAACTGCAGTAATTGTTTAACC
ATCACTTGTCTCCTCGGCTGTTTTATAAAAGGACAAAACAGCAAGTGTCTGCATTGCATC
TCGGTTTCTCCCATTAGCGAGGAGCAAGACAAAAAGACAGAGGAGAAAGTGAGCCTAAGG
GGAAAGAGAATTGCTGAGTACTCCTATGGGCATCAAAAGAAATCAAGCAAGAAGAAAAAA
ATCAGTAAGAATGACATCCGCCTGGTACCCCGGGATGTGGAGGAGACAGACAAGATGAAC
GTTGTCAGTTGCTCTTCCCTGACCTCCTCCCTCAACTATTTTGACTACCACCAGCAGACG
CTGCCCCTGGGCTGCCGCCGCTCTGAGAGCACTTTCCTGAATGTGGAGAACCAGAATACC
CGCAACACCAGTGCTAACCACATCTACCATCACTCTTTCAACAGCCAGGGGCCCCAGCAG
CCTGACCTGATTATCAACGGTGTGCCTCTGCCTGAGACTGAAAACTATTCTTTTGACTCC
AACTACGTGAATAGCCGAGCCCATTTAATCAAGAGCAGCTCCACCTTCAAGGACTTAGAG
GGCAACAGCCTGAAGGATAGTGGACATGAGGAGAGTGACCAAACTGACAGTGAGCATGAT
GTCCAGCGGAGCCTGTATTGTGATACTGCTGTCAACGATGTGCTGAACACCAGTGTGACC
TCCATGGGATCTCAGATGCCTGATCATGATCAGAATGAAGGATTTCATTGCCGGGAAGAA
TGCCGGATTCTTGGCCACTCTGACAGGTGCTGGATGCCCCGGAACCCCATGCCCATCCGT
TCCAAGTCCCCTGAGCATGTGAGGAACATCATCGCGCTGTCTATTGAAGCTACTGCTGCT
GATGTCGAGGCTTATGACGACTGCGGCCCCACCAAACGGACTTTCGCAACCTTTGGGAAA
GATGTCAGCGACCACCCGGCTGAGGAGAGGCCTACCCTGAAAGGCAAGAGGACTGTCGAT
GTGACCATCTGCAGCCCCAAGGTCAACAGCGTTATCCGGGAGGCAGGCAATGGCTGTGAG
GCGATTAGCCCTGTCACCTCCCCCCTCCACCTCAAGAGCTCTCTGCCCACCAAGCCTTCC
GTGTCTTACACCATTGCCCTGGCTCCCCCAGCCCGTGATCTGGAGCAGTATGTCAACAAT
GTCAACAATGGCCCTACTCGTCCCTCTGAAGCTGAGCCCCGTGGAGCTGATAGCGAGAAA
GTCATGCATGAGGTCAGCCCCATTCTGAAGGAAGGTCGCAACAAAGAGTCCCCTGGTGTG
AAGCGTCTGAAGGATATCGTTCTCTAA
Protein Properties
Number of Residues 1148
Molecular Weight 126251.4
Theoretical pI 5.01
Pfam Domain Function
Signals
  • 1-21
Transmembrane Regions
  • 679-699
Protein Sequence
>Protocadherin-19
MESLLLPVLLLLAILWTQAAALINLKYSVEEEQRAGTVIANVAKDAREAGFALDPRQASA
FRVVSNSAPHLVDINPSSGLLVTKQKIDRDLLCRQSPKCIISLEVMSSSMEICVIKVEIK
DLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPNELFGLEIKT
RGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDSNDNNPVFSE
STYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQIDPHSGLVTV
TGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSVNSELVEVSE
SAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESFSTILVDGRLDREQHDQYN
LTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQVIVQENNTPGAYLLSVSARDP
DLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALRSFNHEQTKAFEFKVLAKDGGL
PSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPRNSGIGYLVTVVKAEDYDEGEN
GRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSYELIVVAHDHGKTSLSASALVLI
YLSPALDAQESMGSVNLSLIFIIALGSIAGILFVTMIFVAIKCKRDNKEIRTYNCSNCLT
ITCLLGCFIKGQNSKCLHCISVSPISEEQDKKTEEKVSLRGKRIAEYSYGHQKKSSKKKK
ISKNDIRLVPRDVEETDKMNVVSCSSLTSSLNYFDYHQQTLPLGCRRSESTFLNVENQNT
RNTSANHIYHHSFNSQGPQQPDLIINGVPLPETENYSFDSNYVNSRAHLIKSSSTFKDLE
GNSLKDSGHEESDQTDSEHDVQRSLYCDTAVNDVLNTSVTSMGSQMPDHDQNEGFHCREE
CRILGHSDRCWMPRNPMPIRSKSPEHVRNIIALSIEATAADVEAYDDCGPTKRTFATFGK
DVSDHPAEERPTLKGKRTVDVTICSPKVNSVIREAGNGCEAISPVTSPLHLKSSLPTKPS
VSYTIALAPPARDLEQYVNNVNNGPTRPSEAEPRGADSEKVMHEVSPILKEGRNKESPGV
KRLKDIVL
GenBank ID Protein 296434287
UniProtKB/Swiss-Prot ID Q8TAB3
UniProtKB/Swiss-Prot Entry Name PCD19_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001184880.1
GeneCard ID PCDH19
GenAtlas ID PCDH19
HGNC ID HGNC:14270
References
General References
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  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [PubMed:10718198 ]
  5. Wolverton T, Lalande M: Identification and characterization of three members of a novel subclass of protocadherins. Genomics. 2001 Aug;76(1-3):66-72. [PubMed:11549318 ]
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