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Identification
HMDB Protein ID HMDBP07876
Secondary Accession Numbers
  • 13587
Name Cadherin-related family member 1
Synonyms
  1. Photoreceptor cadherin
  2. Protocadherin-21
  3. prCAD
Gene Name CDHR1
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 10q23.1
SNPs CDHR1
Gene Sequence
>2580 bp
ATGAGGCGCTGCCGGTGGGCCGCCCTGGCCCTGGGGCTGCTGCGCCTCTGCTTGGCTCAG
GCCAACTTCGCCCCGCACTTCTTCGACAACGGGGTCGGCAGCACCAACGGAAACATGGCT
CTGTTCAGCCTCCCAGAGGACACCCCTGTAGGCTCTCACGTATACACCCTGAATGGGACA
GACCCTGAGGGAGACCCCATCTCCTACCACATCAGCTTTGACCCCAGCACTAGAAGCGTC
TTTTCTGTTGACCCCACTTTTGGAAACATCACCCTGGTTGAAGAGCTGGACAGAGAGAGG
GAAGATGAGATTGAAGCCATCATCAGCATTTCTGATGGCCTGAATCTGGTGGCCGAAAAA
GTCGTGATCCTGGTGACCGATGCCAATGATGAGGCGCCCAGGTTCATCCAGGAGCCTTAT
GTTGCCCTGGTTCCCGAGGACATACCTGCTGGGAGCATCATCTTTAAGGTCCATGCAGTG
GACAGGGACACAGGCTCTGGAGGGAGTGTCACCTACTTCCTGCAGAACCTGCACTCCCCA
TTTGCCGTGGACCGCCACAGCGGTGTGCTGCGCCTCCAGGCTGGGGCCACTCTGGACTAC
GAGAGGTCCCGGACCCACTACATCACCGTGGTCGCCAAGGATGGCGGTGGGAGGCTTCAT
GGGGCTGATGTGGTGTTCTCAGCCACCACCACGGTCACGGTCAATGTGGAGGATGTTCAG
GACATGGCCCCTGTCTTCGTGGGCACACCCTACTATGGCTATGTGTACGAGGACACCCTT
CCGGGCTCGGAGGTACTGAAGGTGGTCGCCATGGATGGAGACCGGGGCAAACCCAATCGA
ATTCTCTACAGCCTTGTAAATGGGAACGATGGAGCCTTTGAAATTAATGAGACATCTGGA
GCCATCTCCATCACTCAGAGCCCGGCCCAGCTCCAGAGAGAGGTGTATGAGCTGCATGTA
CAGGTGACTGAAATGAGCCCTGCGGGGAGCCCAGCTGCCCAGGCCACCGTCCCAGTCACC
ATCAGGATTGTGGACCTCAACAACCACCCGCCAACATTCTATGGAGAGAGCGGACCCCAA
AACAGGTTTGAGCTGTCCATGAATGAGCACCCACCCCAGGGAGAGATCCTGCGGGGCCTC
AAGATCACCGTCAATGACTCCGACCAGGGAGCCAATGCCAAATTCAACTTGCAGCTGGTG
GGACCCAGGGGCATCTTCCGAGTGGTTCCACAGACAGTCCTGAATGAAGCCCAAGTCACA
ATCATTGTGGAGAACTCAGCTGCCATTGACTTTGAAAAGTCCAAAGTATTAACCTTCAAG
CTCCTGGCTGTTGAAGTGAACACCCCAGAGAAGTTCAGTTCCACAGCGGATGTTGTGATC
CAGCTCCTGGACACCAATGACAATGTCCCCAAGTTCGACTCCCTCTACTACGTTGCCAGG
ATTCCTGAGAACGCCCCAGGGGGCTCCAGCGTGGTGGCTGTCACAGCTGTGGATCCAGAT
ACAGGACCCTGGGGCGAAGTGAAATATTCCACCTATGGGACTGGGGCAGACCTCTTCCTG
ATCCACCCATCCACTGGGCTTATCTACACCCAGCCCTGGGCTAGCCTGGACGCTGAGGCC
ACTGCCAGGTACAACTTCTATGTGAAGGCAGAGGACATGGAAGGCAAGTACAGCGTAGCT
GAGGTGTTTATCACACTGCTGGATGTCAATGACCACCCCCCTCAGTTTGGAAAGAGCGTT
CAGAAGAAGACGATGGTGCTAGGGACCCCAGTGAAAATTGAGGCCATAGACGAGGATGCA
GAGGAACCCAACAACCTGGTGGACTATTCCATCACCCATGCAGAGCCCGCCAACGTGTTC
GACATCAATTCCCACACGGGGGAGATCTGGCTCAAGAATTCCATCCGCTCCCTGGATGCC
CTGCACAACATCACACCTGGAAGGGACTGCCTATGGTCCCTAGAGGTGCAGGCCAAGGAC
CGGGGCTCCCCATCCTTCAGCACCACAGCCTTACTCAAGATTGACATCACAGATGCTGAG
ACCCTCTCCCGGAGCCCCATGGCTGCCTTCCTGATACAGACCAAGGACAACCCCATGAAG
GCCGTGGGTGTGCTGGCCGGCACCATGGCCACCGTCGTGGCCATCACTGTCCTCATCTCC
ACCGCCACCTTCTGGCGCAACAAGAAGTCTAACAAGGTCCTGCCAATGCGGCGGGTGCTC
CGCAAGCGGCCCAGCCCTGCGCCCCGCACCATCCGCATTGAGTGGCTCAAGTCCAAGAGC
ACCAAAGCCGCTACCAAGTTCATGCTCAAAGAGAAACCTCCCAATGAGAACTGTAACAAC
AACAGCCCAGAAAGCTCTCTGCTCCCGAGAGCTCCGGCTCTCCCTCCACCACCCAGCGTG
GCGCCCAGCACTGGCGCAGCCCAGTGGACCGTGCCTACTGTCTCTGGCTCTCTCACTCCG
CAGCCGACCCAACCCCCGCCAAAACCCAAAACTATGGGAAGCCCCGTCCAGTCAACTCTG
ATCTCTGAGCTCAAGCAAAAGTTTGAGAAGAAGAGTGTGCACAACAAGGCTTACTTCTAG
Protein Properties
Number of Residues 859
Molecular Weight 93594.1
Theoretical pI 5.22
Pfam Domain Function
Signals
  • 1-19
Transmembrane Regions
  • 701-721
Protein Sequence
>Cadherin-related family member 1
MRRCRWAALALGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGT
DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEK
VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP
FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ
DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG
AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ
NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVT
IIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVAR
IPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEA
TARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAIDEDA
EEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKD
RGSPSFSTTALLKIDITDAETLSRSPMAAFLIQTKDNPMKAVGVLAGTMATVVAITVLIS
TATFWRNKKSNKVLPMRRVLRKRPSPAPRTIRIEWLKSKSTKAATKFMLKEKPPNENCNN
NSPESSLLPRAPALPPPPSVAPSTGAAQWTVPTVSGSLTPQPTQPPPKPKTMGSPVQSTL
ISELKQKFEKKSVHNKAYF
GenBank ID Protein 16933565
UniProtKB/Swiss-Prot ID Q96JP9
UniProtKB/Swiss-Prot Entry Name CDHR1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_033100.2
GeneCard ID CDHR1
GenAtlas ID CDHR1
HGNC ID HGNC:14550
References
General References
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  5. Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K: Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest. 2008 Aug;118(8):2908-16. doi: 10.1172/JCI35891. [PubMed:18654668 ]
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