Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP07885
Secondary Accession Numbers
  • 13596
Name Protocadherin alpha-8
Synonyms
  1. PCDH-alpha-8
Gene Name PCDHA8
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHA8
Gene Sequence
>2853 bp
ATGGATTATCACTGGCGAGGAGAGCTGGGATCCTGGCGACTACTACTCTTGCTTCTGCTC
CTCGCAGCCTGGAAGGTGGGGAGCGGCCAGCTCCACTACTCCGTCCCCGAGGAGGCCAAA
CACGGCACCTTCGTGGGCCGGATCGCGCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAAAGACACCGGGACCTTCTGGAGGTAAGTCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGGAGCTGTGCGGGCGGAGCGCG
GAGTGCAGCATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTTCCATGTGGAC
GTGGAGGTGAAGGATGTTAATGACAACCCGCCAGTGTTCCGGGTAAAAGACCAAAAGCTG
TTTGTTTCAGAATCCAGAATGCCAGACTCTCGGTTTCCGCTAGAGGGCGCGTCCGATGCA
GATGTTGGAGCTAACTCCGTGTTAACCTACAGGCTTAGCTCTCATGATTACTTCATGCTA
GATGTGAATTCAAAGAACGATGAGAATAAACTGGTTGAGCTCGTATTAAGAAAATCCTTG
GACAGAGAGGACGCTCCTGCGCACCACTTATTCCTGACAGCCACAGATGGGGGCAAACCT
GAGCTCACAGGCACTGTTCAGCTGCTGGTCACAGTGCTGGATGTGAATGATAATGCTCCC
ACTTTCGAACAGTCTGAATACGAAGTAAGAATATTCGAAAACGCAGACAACGGAACAACA
GTTATCAAACTGAATGCTTCTGATCCGGATGAAGGAGCCAATGGGGCAATTTCATATTCT
TTTAATAGCCTTGTTGAAACTATGGTTATTGACCACTTTAGCATAGATCGAAATACGGGA
GAAATAGTGATTCGGGGTAATTTGGATTTTGAACAAGAAAACTTATACAAAATCCTCATT
GACGCCACGGACAAAGGCCATCCTCCCATGGCGGGTCATTGCACCGTTTTAGTGAGAATT
TTGGATAAAAATGATAACGTCCCTGAGATAGCACTGACTTCCTTATCCTTGCCTGTACGT
GAAGACGCTCAATTTGGTACTGTCATCGCCCTAATTAGCGTGAACGACCTCGATTCAGGT
GCCAACGGGCAGGTGACCTGCTCCCTGATGCCCCATGTCCCCTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCGTTGGTGCTGGACAGCGCCCTGGACCGCGAGAGAGTGTCGGCC
TATGAGTTGGTGGTAACCGCGCGGGACGGGGGCTCGCCTTCGCTGTGGGCCACCGCCAGC
TTGTCTGTGGAGGTGGCCGACGTGAACGACAATGCTCCGGCGTTCGCGCAGCCCGAGTAC
ACGGTGTTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCTGCGCGA
GACGCGGACGCGCAGGAGAACGCGCTGGTGTCCTACTCGCTTGTGGAGCGGCGGGTGGGC
GAGCGCTCGCTGTCGAGCTACATTTCGGTGCACACGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTGGACCACGAGGAGCTAGAGCTGCTGCAGTTCCAGGTGAGCGCGCGCGACGCG
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAATGAC
AACGCGCCGGCACTGCTGGAGCCTCGGGTGGGTGGCACTGGTGGCGCAGCGAGCAAGCTG
GTGCCGCGGTCTGTGGGCGCGGGCCACGTGGTAGCGAAGGTGCGCGCAGTGGACGCCGAC
TCGGGCTACAACGCGTGGCTTTCGTATGAGCTGCAGCCAGCTGCAAGCAGCCCTCGCATC
CCGTTCCGCGTGGGGCTGTACACGGGCGAGATCAGCACCACTCGTGTCCTGGACGAAGCG
GACTCTCCGCGCCACCGTCTGCTGGTCCTGGTGAAGGATCATGGTGAACCTGCGCTGACC
GCCACGGCCACGGTTCTGGTGTCGCTGGTGGAGAGCGGCCAGGCTCCAAAAGCGTCATCG
AGGCAGTCGGCTGGCGTTTTGGGTCCGGAAGCGGCGCTGGTGGATGTCAACGTGTACCTG
ATCATCGCCATCTGCGCGGTATCCAGCCTGCTGGTGCTCACGCTGCTGCTGTACACTGCG
CTGCGGTGCTCAGCACTGCCCACTGAGGGCGGGTGCCGGGCGGGCAAGCCCACTCTGGTG
TGCTCCAGTGCGGTGGGGAGCTGGTCATACTCGCAACAACAGCCGCAGAGGGTGTGCTCT
GGTGAGGGGCCACCGAAGACGGACCTCATGGCCTTCAGCCCCTGCCTTCCTCCTGATCTG
GGATCAGTTGATGTAGGCGAAGAGCAAGATTTAAATGTTGATCATGGCCTCAAACCACGA
CAGCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTG
CACCTAGAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCA
ACAGTATCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCG
GGTGTCAACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGT
CCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGG
CAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAG
GAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAA
GGGAACAGCACGACTGACAACAGTGACCAGTGA
Protein Properties
Number of Residues 950
Molecular Weight 103050.1
Theoretical pI 4.93
Pfam Domain Function
Signals
  • 1-29
Transmembrane Regions
  • 698-718
Protein Sequence
>Protocadherin alpha-8
MDYHWRGELGSWRLLLLLLLLAAWKVGSGQLHYSVPEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKRHRDLLEVSLQNGILFVNSRIDREELCGRSAECSIHLEVIVDRPLQVFHVD
VEVKDVNDNPPVFRVKDQKLFVSESRMPDSRFPLEGASDADVGANSVLTYRLSSHDYFML
DVNSKNDENKLVELVLRKSLDREDAPAHHLFLTATDGGKPELTGTVQLLVTVLDVNDNAP
TFEQSEYEVRIFENADNGTTVIKLNASDPDEGANGAISYSFNSLVETMVIDHFSIDRNTG
EIVIRGNLDFEQENLYKILIDATDKGHPPMAGHCTVLVRILDKNDNVPEIALTSLSLPVR
EDAQFGTVIALISVNDLDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRERVSA
YELVVTARDGGSPSLWATASLSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
DADAQENALVSYSLVERRVGERSLSSYISVHTESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLEPRVGGTGGAASKLVPRSVGAGHVVAKVRAVDAD
SGYNAWLSYELQPAASSPRIPFRVGLYTGEISTTRVLDEADSPRHRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRQSAGVLGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSALPTEGGCRAGKPTLVCSSAVGSWSYSQQQPQRVCSGEGPPKTDLMAFSPCLPPDL
GSVDVGEEQDLNVDHGLKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP
TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR
QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
GenBank ID Protein 9256596
UniProtKB/Swiss-Prot ID Q9Y5H6
UniProtKB/Swiss-Prot Entry Name PCDA8_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018911.2
GeneCard ID PCDHA8
GenAtlas ID PCDHA8
HGNC ID HGNC:8674
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [PubMed:15372022 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]