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Identification
HMDB Protein ID HMDBP07889
Secondary Accession Numbers
  • 13600
Name Protocadherin alpha-12
Synonyms
  1. PCDH-alpha-12
Gene Name PCDHA12
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHA12
Gene Sequence
>2826 bp
ATGGTGATTATCGGACCAAGAGGCCCGGGATCCCAGCGTCTGCTGCTCTCGCTTCTGCTC
CTTGCAGCCTGGGAGGTGGGGAGCGGCCAGCTCCACTACTCCGTCTACGAGGAGGCCAAA
CACGGCACCTTCGTGGGCCGCATCGCTCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAAAGACACGGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGAAGCTGTGCGGGCGGAGCGCG
GAGTGCAGTATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTTCCATGTGGAC
GTGGAGGTGAAGGACATTAACGACAACCCGCCGGTGTTCAGAGAAAGGGAACAAAAGGTA
CCTGTTTCTGAATCTGCGCCTCTGGACTCTCATTTTCCTCTAGAGGGCGCTTCTGATGCG
GATATCGGCGTAAACTCTCTTTTGACCTATGCGTTAAGTCTAAATGAGAATTTTGAGCTT
AAAATAAAAACAAAAAAAGATAAAAGTATATTGCCTGAATTAGTTCTTCGGAAGTTATTG
GACAGAGAGCAAACGCCAAAACTCAATTTATTGCTGATGGTAATCGATGGCGGTAAACCA
GAACTAACAGGGTCTGTCCAGATTCAAATAACCGTCCTGGATGTGAATGACAATGGTCCG
GCGTTTGATAAGCCCAGCTATAAAGTAGTGTTGTCTGAAAATGTCCAAAACGACACAAGA
GTGATCCAACTAAATGCTTCCGATCCAGACGAAGGACTTAATGGAGAAATTTCCTATGGG
ATCAAAATGATTTTGCCAGTGAGTGAGAAATGTATGTTTTCAATAAATCCAGACACAGGT
GAAATTAGAATTTATGGTGAACTGGATTTTGAAGAGAATAATGCCTATGAAATTCAGGTT
AACGCCATTGATAAAGGGATTCCTTCCATGGCAGGTCACAGCATGGTCCTGGTGGAAGTT
CTGGACGTGAATGACAATGTCCCTGAAGTAATGGTTACTTCACTGTCGCTCCCTGTGCAA
GAGGATGCTCAGGTGGGTACCGTCATTGCCCTGATTAGCGTGTCGGATCGTGACTCTGGA
GCCAATGGACAGGTCATCTGCTCACTGACACCTCATGTTCCCTTCAAGCTGGTGTCCACC
TACAAGAATTACTACTCGTTGGTGCTGGACAGCGCCCTGGACCGCGAGAGCGTGTCGGCC
TATGAGCTGGTGGTGACTGCGCGGGATGGGGGCTCGCCTTCGCTGTGGGCCACGGCTAGA
GTGTCCGTGGAGGTGGCCGACGTGAACGACAATGCGCCTGCGTTCGCGCAGCCCGAGTAC
ACAGTGTTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCGGCATGG
GACGCGGACGCGCAGAAGAACGCGCTGGTGTCCTACTCGCTGGTGGAGCGGCGGGTGGGC
GAGCACGCACTGTCGAGCTACGTGTCGGTGCACGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTAGACCACGAGGAGCTGGAGCTGCTGCAGTTCCAGGTGAGCGCGCGCGACGCC
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCGCCGGCACTGCTGGCGACTCCGGCTGGCAGCGCAGGAGGCGCAGTTAGCGAGTTG
GTACCGCGGTCGGTGGGTGCGGGCCACGTGGTGGCGAAAGTGCGCGCGGTGGACGCTGAC
TCCGGCTATAACGCTTGGCTGTCCTACGAGTTGCAACCGGCGGCGGTCGGCGCGCACATC
CCGTTCCACGTGGGGCTGTACACTGGCGAGATCAGCACGACACGCATCCTGGATGAGGCG
GACGCTCCGCGCCACCGCCTGCTGGTGCTGGTGAAGGACCACGGTGAGCCCGCGCTGACG
TCCACGGCCACGGTGCTGGTGTCGCTGGTGGAGAACGGCCAGGCCCCAAAGACGTCGTCG
CGGGCCTCAGTGGGCGCTGTGGATCCCGAAGCGGCTCTGGTGGATATTAACGTGTACCTC
ATCATCGCCATCTGTGCGGTGTCCAGCCTGCTGGTGCTCACGCTGCTGCTGTACACTGCG
CTGCGTTGCTCAGCGCCGCCCACCGTGAGCCGGTGCGCGCCGGGCAAGCCCACGCTGGTG
TGCTCCAGCGCCGTGGGGAGTTGGTCTTACTCGCAGCAGAGGAGGCAGAGGGTGTGCTCT
GCAGAGAGCCCGCCCAAGACGGACCTCATGGCCTTCAGCCCAAGCCTTCAGCTGTCTCGA
GAAGATTGTTTAAATCCTCCCAGTGAACCACGACAGCCCAACCCTGACTGGCGTTACTCT
GCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTAGAGGAGGCTGGCATTCTACGG
GCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTATCCAGTGCAACACCAGAACCA
GAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAACAGCAACAGCTGGACCTTT
AAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAGTTGCCCGACAAATTCATT
ATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCTACTAACAGCCAAATTGAC
AAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAGAAAAAGAAGAAAAAGAAG
AAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAACAGCACGACTGACAACAGTGAC
CAGTGA
Protein Properties
Number of Residues 941
Molecular Weight 101651.1
Theoretical pI 4.91
Pfam Domain Function
Signals
  • 1-29
Transmembrane Regions
  • 698-718
Protein Sequence
>Protocadherin alpha-12
MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVD
VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFEL
KIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGP
AFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTG
EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQ
EDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW
DADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDAD
SGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALT
STATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLIIAICAVSSLLVLTLLLYTA
LRCSAPPTVSRCAPGKPTLVCSSAVGSWSYSQQRRQRVCSAESPPKTDLMAFSPSLQLSR
EDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP
EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID
KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
GenBank ID Protein 9256578
UniProtKB/Swiss-Prot ID Q9UN75
UniProtKB/Swiss-Prot Entry Name PCDAC_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018903.2
GeneCard ID PCDHA12
GenAtlas ID PCDHA12
HGNC ID HGNC:8666
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Schmutz J, Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM: The DNA sequence and comparative analysis of human chromosome 5. Nature. 2004 Sep 16;431(7006):268-74. [PubMed:15372022 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]