| Identification |
|---|
| HMDB Protein ID
| HMDBP07896 |
| Secondary Accession Numbers
| |
| Name
| Protocadherin beta-6 |
| Synonyms
|
- PCDH-beta-6
|
| Gene Name
| PCDHB6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHB6 |
| Gene Sequence
|
>2385 bp
ATGATGCAAACTAAAGTACAGAACAAGAAAAGGCAAGTGGCTTTCTTCATTTTATTGATG
CTTTGGGGAGAGGTGGGTTCTGAATCGATTCAGTATTCCGTATTGGAGGAGACAGAAAGT
GGCACGTTTGTGGCCAACTTGACAAAGGACCTGGGACTGAGGGTGGGGGAGCTGGCTTCG
CGGGGCGCTCGGGTTGTTTTCAAAGGGAACAGACAACATTTGCAGTTTGATCCACAGACC
CATGATTTACTGCTAAATGAAAAACTGGACCGGGAGGAGCTGTGTGGCTCCACTGAGCCG
TGTGTGCTACCTTTCCAAGTGTTACTGGAAAACCCCTTGCAGTTTTTTCAGGCTTCCTTG
CGAGTCAGAGATATAAATGACCACGCCCCGGAATTCCCTGCCAGAGAAATGCTCCTGAAA
ATATCAGAAATTACTATGCCAGGAAAGATATTTCCTTTGAAAATGGCACACGATTTAGAC
ACCGGCAGCAACGGCCTTCAGAGGTACACAATCAGCTCCAACCCTCACTTCCACGTTCTC
ACCCGCAATCGCAGCGAAGGCAGGAAGTTCCCGGAGCTGGTGCTAGACAAACCGTTGGAC
CGCGAGGAGCAGCCCCAACTCAGGCTAACGCTGATCGCGCTGGATGGCGGGTCTCCGCCC
CGGTCAGGGACCTCCGAGATTCAGATCCAGGTTTTGGACATCAATGACAACGTCCCCGAG
TTTGCTCAGGAGCTCTATGAAGCACAAGTCCCTGAGAACAACCCCCTCGGCTCTCTGGTT
ATTACCGTCTCAGCCAGAGATTTAGATGCAGGATCGTTTGGGAAGGTATCTTACGCCCTG
TTTCAAGTCGATGACGTCAACCAACCCTTCGAAATAAACGCAATCACAGGAGAAATTCGG
CTGAGAAAGGCTTTGGATTTTGAGGAAATTCAGTCTTATGACGTGGATGTTGAGGCTACA
GATGGTGGAGGCCTATCAGGAAAATGCTCTTTAGTCGTCAGGGTCCTGGACGTGAATGAC
AATGCCCCTGAACTCACCATGTCGTTCTTCATCAGCCTCATCCCAGAAAACTTACCAGAG
ATCACAGTGGCAGTTTTCAGTGTTTCAGATGCAGACTCTGGACATAACCAACAGGTTATT
TGTTCAATAGAGAACAATCTCCCCTTTCTACTAAGACCTTCCGTGGAGAATTTCTACACC
CTGGTAACAGAAGGCGCGCTGGACAGAGAGAGCAGAGCCGAGTACAACATCACTATCACG
GTCACTGATTTGGGGACACCAAGGCTGAAAACCCAGCAGAGCATAACTGTGCAGGTCTCC
GACGTCAATGACAACGTCCCCGCCTTCACCCAAACCTCCTACACCCTGTTCGTCCGCGAG
AACAACAGCCCCGCCCTGCACATCGGCAGCGTCAGCGCCACAGACAGAGACTCAGGCATC
AACGCCCAGGTCACCTACTCGCTGCTGCCGCCCCAGGACCCGCACCTGCCCCTCTCTTCC
CTGGTCTCCATCAACGCGGACAACGGCCACCTGTTTGCCCTCAGGTCGCTGGACTACGAG
GCCCTGCAGTCTTTCGAGTTCCGCGTGGGCGCCACAGACCGCGGCTCCCCGGCGTTGAGC
AGCGAGGCGCTGGTGCGCTTGCTGGTGCTGGACGCCAACGACAACTCGCCCTTCGTGTTG
TACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCGGCCGAGCCG
GGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAACGCCTGGCTG
TCGTACCAGCTGCTCAAGGCCACGGAGCTCGGTCTGTTCGGCGTGTGGGCGCACAATGGC
GAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGAGACGCAGCCAAGCACAGGCTGGTGGTG
CTTGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTGCACGTGCTCCTG
GTGGACGGCTTCTCCCAGCCCTACCTGCCTCTCCCTGAGGCGGCCCCGGCCCAAGCCCAG
GCCGACTCTCTCACCGTCTACCTGGTGGTGGCGTTGGCCTCGGTGTCGTCGCTCTTCCTC
TTTTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCCTCGGTG
GGTCGCTACTCGGTGCCCGAGGGTCCCTTTCCAGGGCATCTGGTGGATGTGAGCGGCACC
GGGACCCTATCCCAGAGCTACCAGTACAAGGTGTGTCTGACGGGAGGCTCAGAAACAAAT
GAGTTCAAGTTCCTGAAGCCGATTATGCCCAACTTCCCTCCTCAGGGCACTGAGAGAGAA
ATGGAAGAAACCCCCACCTCTCGGAATAGCTTCCCGTTCAGTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 794 |
| Molecular Weight
| 87348.9 |
| Theoretical pI
| 4.63 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin beta-6
MMQTKVQNKKRQVAFFILLMLWGEVGSESIQYSVLEETESGTFVANLTKDLGLRVGELAS
RGARVVFKGNRQHLQFDPQTHDLLLNEKLDREELCGSTEPCVLPFQVLLENPLQFFQASL
RVRDINDHAPEFPAREMLLKISEITMPGKIFPLKMAHDLDTGSNGLQRYTISSNPHFHVL
TRNRSEGRKFPELVLDKPLDREEQPQLRLTLIALDGGSPPRSGTSEIQIQVLDINDNVPE
FAQELYEAQVPENNPLGSLVITVSARDLDAGSFGKVSYALFQVDDVNQPFEINAITGEIR
LRKALDFEEIQSYDVDVEATDGGGLSGKCSLVVRVLDVNDNAPELTMSFFISLIPENLPE
ITVAVFSVSDADSGHNQQVICSIENNLPFLLRPSVENFYTLVTEGALDRESRAEYNITIT
VTDLGTPRLKTQQSITVQVSDVNDNVPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGI
NAQVTYSLLPPQDPHLPLSSLVSINADNGHLFALRSLDYEALQSFEFRVGATDRGSPALS
SEALVRLLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNAWL
SYQLLKATELGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHVLL
VDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAASV
GRYSVPEGPFPGHLVDVSGTGTLSQSYQYKVCLTGGSETNEFKFLKPIMPNFPPQGTERE
MEETPTSRNSFPFS
|
| External Links |
|---|
| GenBank ID Protein
| 5457047 |
| UniProtKB/Swiss-Prot ID
| Q9Y5E3 |
| UniProtKB/Swiss-Prot Entry Name
| PCDB6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF152499 |
| GeneCard ID
| PCDHB6 |
| GenAtlas ID
| PCDHB6 |
| HGNC ID
| HGNC:8691 |
| References |
|---|
| General References
| - Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
- Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
- Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]
|
