Human Metabolome Database: Showing Protein Protocadherin beta-9 (HMDBP07899)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07899

Secondary Accession Numbers

13610

Name

Protocadherin beta-9

Synonyms

PCDH-beta-9
Protocadherin-3H

Gene Name

PCDHB9

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHB9

Gene Sequence

>2394 bp
ATGAAGACCAGGGGGTTCAGCTTTCCAAGACAAAGGCAAGTCCTGTTTCTTTTTCTTTTC
TGGGGAGTGTCCTTGGCAGGTTCTGGGTTTGGACGTTATTCGGTGACTGAGGAAACAGAG
AAAGGATCCTTTGTGGTCAATCTGGCAAAGGATCTGGGACTAGCAGAGGGGGAGCTGGCT
GCAAGGGGAACCAGGGTGGTTTCCGATGATAACAAACAATACCTGCTCCTGGATTCACAT
ACCGGGAATTTGCTCACAAATGAGAAACTGGACCGAGAGAAGCTGTGTGGCCCTAAAGAG
CCCTGTATGCTGTATTTCCAAATTTTAATGGATGATCCCTTTCAGATTTACCGGGCTGAG
CTGAGAGTCAGGGATATAAATGATCACTCGCCAGTGTTTCGGCACAAAGAGATGGTCTTA
AAAATATCAGAAAATACAGCTGAAGGGACAGCATTTAGACTAGAAAGAGCACAGGATCCA
GATGAAGGTCATAACAGTATCCAAAACTACACGATCAGCTCCAACTCTTTTTTCCATATT
AAAATTAGTGGCAGTGATGAAGGCATGATATATCCAGAGCTAGTGTTGGACAAAGCACTG
GATCGGGAGGAGCAGGAAGAGCTCAGCTTAACCCTCACAGCGCTGGATGGTGGGTCTCCA
TCCAGGTCTGGGACCTCCACTATACGCATTGTGGTCTTGGATGTCAATGACAATGCCCCA
CAGTTTGCCCAGGCTCTGTATGAGACCCAGGCTCCAGAAAACAGTCCAGTAGGGTCCCTT
ATTGTTAAAGTGTCTGCAGGAGATGCAGACTCAGGAGTCAATGCAGAAGTATCCTATTCA
TTTTTTGATGCTTCTGAAGATATTTTAACAACGTTTCAAATCAATCCTTTTTCTGGGGAA
ATCTTTCTCAGAGAATTGCTTGATTATGAGTTAGTAAATTCTTACAAAATAAATATACAG
GCAATGGACGGCGGAGGCCTTTCTGCAAGATGTACAGTTTTGATAAAAGTATTAGATTCC
AATGACAATCCTCCTGAACTGATCATATCATCACTTTCCAACTCTGTTGCTGAAAACTCT
CCTGGGATAGTATTGGCTGTTTTTAAGATTAAAGACAGAGACTCCGGAGAAAATGGAAAG
ACAATTTGCTATGTTCAAGATAATCTGCCTTTTTTTCTGAAACCGTCTGTTGACAATTTT
TACATCCTAATGACTGAAGGTGCACTGGACAGAGAGAGCAAAGCTGAGTACAACATCACC
ATCACCGTCACTGACTTGGGGACACCCAGGCTGAAAACCGAGCACAGCATAACCCTGCAG
GTCTCCGACGTCAATGACAACGCCCCCGCCTTCACCCAAACCTCCTACACCCTGTTCGTC
CGGGAGAACAACAGCCCCGCCCTGCACATCGGCAGTGTCAGCGCCACAGACAGAGACTCA
GGCACCAACGCCCAGGTCACCTACTCGCTGCTGCCGCCCCAGGACCCACACCTGCCCCTC
GCCTCCCTGGTCTCCATCAACGCGGACAATGGCCACCTGTTTGCCCTCAGGTCGCTGGAC
TACGAGGCCCTGCAGGCTTTCGACTTCCGCGTGGGCGCCTCAGACCGCGGCTCCCCGGCT
TTGAGCAGCGAGGCGCTGGTGCGCGTACTGGTGCTGGACGCCAACGACAACTCGCCCTTC
GTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCGGCC
GAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAACGCC
TGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTGTTCGGTGTGTGGGCGCAC
AATGGGGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCAGCCAAGCACAGGCTG
GTGGTGCTTGTCAAGGACAATGGCGAGCCTCCTCGCTCGGCCACCGCCACGCTGCACGTG
CTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCCTCTCCCGGAGGCGGCCCCGGCCCAG
GCCCAGGCCGACTTGCTCACCGTCTACCTGGTGGTGGCGTTGGCCTCGGTGTCTTCGCTC
TTCCTCCTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCC
TCGGTGGGTCGCTGCTCGGTGCCCGAGGGTCCTTTTCCAGGGCATCTGGTGGACGTGAGC
GGCACCGGGACCCTGTTCCAGAGCTACCAGTACGAGGTGTGTCTGACTGGAGGTTCAGAG
ACCGGCGAGTTCAAGTTCTTGAAGCCGATTACCCCCCACCTCCCGCCCCATAGGGGTGGG
AAAGAAATAGAGGAAAATTCTACTCTCCCCAATAGCTTTGGATTTAATTATTGA

Protein Properties

Number of Residues

797

Molecular Weight

87098.2

Theoretical pI

4.64

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-26

Transmembrane Regions

691-711

Protein Sequence

>Protocadherin beta-9
MKTRGFSFPRQRQVLFLFLFWGVSLAGSGFGRYSVTEETEKGSFVVNLAKDLGLAEGELA
ARGTRVVSDDNKQYLLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAE
LRVRDINDHSPVFRHKEMVLKISENTAEGTAFRLERAQDPDEGHNSIQNYTISSNSFFHI
KISGSDEGMIYPELVLDKALDREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNAP
QFAQALYETQAPENSPVGSLIVKVSAGDADSGVNAEVSYSFFDASEDILTTFQINPFSGE
IFLRELLDYELVNSYKINIQAMDGGGLSARCTVLIKVLDSNDNPPELIISSLSNSVAENS
PGIVLAVFKIKDRDSGENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNIT
ITVTDLGTPRLKTEHSITLQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDS
GTNAQVTYSLLPPQDPHLPLASLVSINADNGHLFALRSLDYEALQAFDFRVGASDRGSPA
LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV
LLVDGFSQPYLPLPEAAPAQAQADLLTVYLVVALASVSSLFLLSVLLFVAVRLCRRSRAA
SVGRCSVPEGPFPGHLVDVSGTGTLFQSYQYEVCLTGGSETGEFKFLKPITPHLPPHRGG
KEIEENSTLPNSFGFNY

External Links

GenBank ID Protein

11142065

UniProtKB/Swiss-Prot ID

Q9Y5E1

UniProtKB/Swiss-Prot Entry Name

PCDB9_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]