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Identification
HMDB Protein ID HMDBP07902
Secondary Accession Numbers
  • 13613
Name Protocadherin beta-12
Synonyms
  1. PCDH-beta-12
Gene Name PCDHB12
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHB12
Gene Sequence
>2388 bp
ATGGAAAACGGAGGGGCAGGCACTCTGCAGATAAGGCAAGTCCTGCTTTTCTTTGTTTTG
CTGGGAATGTCTCAGGCGGGCTCTGAAACTGGGAACTTTTTGGTGATGGAGGAATTGCAG
AGCGGGAGCTTTGTAGGAAATTTGGCAAAGACCCTGGGACTCGAGGTGAGTGAGCTGTCT
TCGCGGGGGGCTCGGGTGGTTTCTAATGATAACAAAGAGTGTTTGCAGCTGGACACAAAC
ACTGGGGATTTGCTCCTGAGAGAAATGCTAGACAGGGAGGAGCTCTGTGGCTCCAATGAG
CCTTGTGTGCTGTATTTCCAAGTGTTAATGAAAAACCCCACGCAGTTTTTACAAATTGAG
CTCCAGGTCAGGGATATAAATGATCACTCTCCCGTCTTCTTGGAAAAAGAAATGCTCTTA
GAAATCCCAGAGAACAGTCCTGTTGGTGCTGTGTTCTTGCTTGAAAGTGCAAAGGATTTA
GATGTAGGAATCAATGCTGTAAAAAGCTACACAATAAATCCGAACTCTCATTTCCACGTT
AAAATAAGAGTCAATCCAGACAATAGGAAATACCCTGAGTTAGTTCTGGACAAGGCGCTG
GATTATGAAGAGCGCCCGGAGCTCAGTTTCATCCTCACTGCTCTGGATGGCGGGTCCCCT
CCCAGGTCTGGAACTGCCTTGGTCAGGGTGGTGGTTGTAGATATTAATGACAACTCCCCT
GAGTTTGAGCAGGCTTTTTATGAGGTGAAGATTCTGGAGAATAGCATCCTTGGCTCCCTG
GTTGTGACCGTCTCAGCCTGGGATTTAGACTCTGGAACAAACAGTGAACTATCCTATACC
TTTTCCCATGCCTCAGAAGATATTCGCAAGACATTTGAAATTAATCAAAAGTCTGGTGAC
ATTACTTTAACAGCACCTTTGGATTTTGAAGCAATTGAGTCATACTCAATAATCATTCAA
GCCACAGATGGGGGAGGACTTTTTGGAAAATCTACAGTCAGAATTCAGGTGATGGATGTA
AACGACAACGCTCCTGAAATCACTGTGTCATCAATTACCAGTCCAATCCCAGAAAACACT
CCAGAGACTGTGGTTATGGTTTTCAGGATACGAGACAGAGACTCTGGGGACAACGGAAAG
ATGGTTTGTTCTATCCCGGAGGACATCCCATTCGTGCTAAAATCTTCGGTAAATAATTAC
TACACTTTGGAAACAGAGAGACCGCTGGACAGAGAGAGCAGAGCCGAGTACAACATCACC
ATCACCGTCACCGACTTGGGGACCCCCAGGCTAAAAACCGAGCACAACATAACCGTGCTG
GTCTCCGACGTCAATGACAACGCCCCCGCCTTCACCCAAACTTCCTACGCCCTGTTCGTC
CGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGCATCAGCGCCACAGACAGAGACTCG
GGCACCAACGCCCAGGTCAACTACTCGCTGCTGCCGTCCCAGGACCCGCACCTGCCCCTC
GCCTCCCTGGTCTCCATCAACGCGGACAACGGCCACCTGTTTGCCCTCAGGTCGCTGGAC
TACGAGGCCCTGCAGGGGTTCCAGTTCCGCGTGGGCGCCACAGACCACGGCTCCCCGGCT
TTGAGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACGCCAACGACAACTCGCCCTTC
GTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCTGGGCGGCC
GAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGTGACTCGGGCCAGAACGCC
TGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTATTCGGCGTGTGGGCGCAC
AATGGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCGGCCAAGCACAGGCTG
GTGGTGCTGGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTGCACGTG
CTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCCTCTCCCGGAGGCGGCCCCGGCCCAG
GCCCAGGCCGACTCGCTCACTGTCTACCTGGTGGTGGCGTTGGCCTCAGTGTCGTCGCTC
TTCCTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCC
CCGGTCGGTCGCTGCTCGGTGCCTGAGGGCCCCTTTCCAGGACATCTGGTGGACGTGAGT
GGCACCGGGACCCTGTCCCAGAGCTACCACTATGAGGTGTGTGTGACTGGAGGCTCCAGG
TCAAATAAGTTCAAATTTCTGAAACCAATTATCCCCAACTTCCTACCCCAGAGCACAGGT
AGTGAAGTCGAAGAAAATCCCCCATTTCAGAATAATTTGGGTTTCTGA
Protein Properties
Number of Residues 795
Molecular Weight 86769.0
Theoretical pI 4.46
Pfam Domain Function
Signals
  • 1-26
Transmembrane Regions
  • 691-711
Protein Sequence
>Protocadherin beta-12
MENGGAGTLQIRQVLLFFVLLGMSQAGSETGNFLVMEELQSGSFVGNLAKTLGLEVSELS
SRGARVVSNDNKECLQLDTNTGDLLLREMLDREELCGSNEPCVLYFQVLMKNPTQFLQIE
LQVRDINDHSPVFLEKEMLLEIPENSPVGAVFLLESAKDLDVGINAVKSYTINPNSHFHV
KIRVNPDNRKYPELVLDKALDYEERPELSFILTALDGGSPPRSGTALVRVVVVDINDNSP
EFEQAFYEVKILENSILGSLVVTVSAWDLDSGTNSELSYTFSHASEDIRKTFEINQKSGD
ITLTAPLDFEAIESYSIIIQATDGGGLFGKSTVRIQVMDVNDNAPEITVSSITSPIPENT
PETVVMVFRIRDRDSGDNGKMVCSIPEDIPFVLKSSVNNYYTLETERPLDRESRAEYNIT
ITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSYALFVRENNSPALHIGSISATDRDS
GTNAQVNYSLLPSQDPHLPLASLVSINADNGHLFALRSLDYEALQGFQFRVGATDHGSPA
LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPWAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV
LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA
PVGRCSVPEGPFPGHLVDVSGTGTLSQSYHYEVCVTGGSRSNKFKFLKPIIPNFLPQSTG
SEVEENPPFQNNLGF
GenBank ID Protein 5457031
UniProtKB/Swiss-Prot ID Q9Y5F1
UniProtKB/Swiss-Prot Entry Name PCDBC_HUMAN
PDB IDs Not Available
GenBank Gene ID AF152491
GeneCard ID PCDHB12
GenAtlas ID PCDHB12
HGNC ID HGNC:8683
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
  3. Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]