Human Metabolome Database: Showing Protein Protocadherin beta-14 (HMDBP07904)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP07904

Secondary Accession Numbers

13615

Name

Protocadherin beta-14

Synonyms

PCDH-beta-14

Gene Name

PCDHB14

Protein Type

Unknown

Biological Properties

General Function

Involved in calcium ion binding

Specific Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion

Cellular Location

Cell membrane
Single-pass type I membrane protein

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31

SNPs

PCDHB14

Gene Sequence

>2397 bp
ATGGAGATCAGAGGGGCACTCGATCTGCGAAAAAGGCAAGTTCTAATATTCCTTGTTTTG
CTGGGATTGTCTCGGGCAGGTACTGAATCTGCACACTATTCTGTGGCAGAGGAAACAGAA
ATTGGCTCTTTTGTGGCTAATCTAGCGAGGGACCTAGGGCTGGGGGTGGAGGAGCTGTCT
TCACGTGAAGCCCGGGTAGTGTCTGATGATAATAAAAAGTATTTGCACCTTGATTTGCTG
ACTGGGAATTTGCTCCTAAATGAGAAACTAGACCGAGACGAGCTGTGTGGCTCCACCGAG
CCCTGTGTGCTGCATTTTCAGGTGGTTTTGGAAAACCCTTTACAGTTTTTTCGGTTTGAG
CTGTGTGTCAAAGACATAAATGATCACTCCCCTACATTTCTAGACAAGGAAATACTTATT
AAAATATCAGAAGGTACCACTGTTGGAGCTACCTTTCTAATGGAGAGTGCTCAAGATTTG
GATGTCGGAAGCAACAGTCTCCAAAACTACACAATTAGCCCCAATTCTCACTTCTACATT
AAAATTCCCGACAGTAGTGACAGAAAGATATACCCAGAGCTGGTCCTAGATAGAGCTTTA
GATTATGAACAGGAAGCTGAACTCAGATTAACACTCACAGCAGTGGATGGTGGATCCCCG
CCCAAGTCTGGGACAACTTTGGTTCTCATCAAGGTGTTGGACATCAATGATAATGCCCCT
GAGTTTCCTCAGAGTCTCTATGAGGTGCAAGTCCCCGAGGACAGACCCCTTGGCTCCTGG
ATTGCCACCATCTCAGCTAAGGATCTGGATGCAGGAAACTATGGAAAAATATCTTACACA
TTTTTCCATGCATCAGAAGATATTCGTAAAACATTTGAAATTAATCCAATATCTGGGGAA
GTTAATTTGAGATCACCCCTGGATTTTGAAGTAATACAGTCCTACACTATAAATATTCAG
GCAACAGATGGTGGGGGTCTTTCAGGAAAATGCACCCTTCTAGTTAAAGTTATGGATATA
AACGACAACCCACCAGAAGTGACCATATCGTCGATTACAAAGAGAATTCCAGAGAATGCC
TCAGAGACCCTAGTAGCTCTTTTTAGTATCCTAGACCAAGACTCTGGAGACAATGGGAGG
ATGATTTGCTCTATTCAAGATAACCTCCCTTTTTTCCTGAAACCGACCTTCAAGAACTTT
TTCACTCTAGTTTCTGAAAAAGCACTGGACAGAGAGAGCCAAGCCGAGTACAACATCACG
ATCACCGTCACAGACTTGGGGACACCCAGGCTGAAAACCGAGTACAACATAACCGTGCTG
CTCTCTGACGTCAATGACAACGCCCCCACCTTCACCCAAACCTCCTACACCCTGTTCGTC
CGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGCGTCAGCGCCACAGACAGAGACTCA
GGCACCAACGCCCAGGTCAACTACTCGCTGCTGCCGCCCCAGGACCGGCACCTGCCCCTC
GCCTCCTTGGTCTCCATCAACGCGGACAATGGCCACCTGTTTGCCCTCAGGTCGCTGGAC
TACGAGGCCCTACAGGAGTTCGAGTTTCGCGTGGGCGCCACAGACCGCGGGTCCCCGGCG
TTGAGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACGCCAACGACAACTCGCCCTTC
GTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCGGCC
GAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAACGCC
TGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTGTTCGGCGTGTGGGCGCAC
AATGGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCGGCCAAGCACAGGCTG
GTGGTGCTGGTCAAGGACAATGGCGAGCCTCCTCGCTCGGCCACCGCCACGCTGCACGTG
CTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCCGCTCCCTGAGGCGGCCCCGGCCCAG
GCCCAGGCCGACTCCCTCACCGTCTACCTGGTGGTGGCATTGGCCTCGGTGTCGTCGCTC
TTCCTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCGGCTGTGCAGGAGGAGCAGGGCGGCC
TCGGTGGGTCGCTGCTCGGTGCCCGAGGGTCCCTTTCCAGGGCATCTGGTGGACGTGAGC
GGCACCGGGACCCTGTCCCAGAGCTACCAATACGAGGTGTGTCTGACAGGAGGTTCCGGG
ACAAATGAGTTCAAATTTCTGAAGCCGATTATCCCCAATTTTCAAGTTCATGACACTGGT
AGGAATATGGGGGAAATCGAGAACTTTCGAAATAGCTTTGGACTTAACATTCAATAA

Protein Properties

Number of Residues

798

Molecular Weight

87546.9

Theoretical pI

4.57

Pfam Domain Function

Cadherin (PF00028 )
Cadherin_2 (PF08266 )

Signals

1-26

Transmembrane Regions

687-711

Protein Sequence

>Protocadherin beta-14
MEIRGALDLRKRQVLIFLVLLGLSRAGTESAHYSVAEETEIGSFVANLARDLGLGVEELS
SREARVVSDDNKKYLHLDLLTGNLLLNEKLDRDELCGSTEPCVLHFQVVLENPLQFFRFE
LCVKDINDHSPTFLDKEILIKISEGTTVGATFLMESAQDLDVGSNSLQNYTISPNSHFYI
KIPDSSDRKIYPELVLDRALDYEQEAELRLTLTAVDGGSPPKSGTTLVLIKVLDINDNAP
EFPQSLYEVQVPEDRPLGSWIATISAKDLDAGNYGKISYTFFHASEDIRKTFEINPISGE
VNLRSPLDFEVIQSYTINIQATDGGGLSGKCTLLVKVMDINDNPPEVTISSITKRIPENA
SETLVALFSILDQDSGDNGRMICSIQDNLPFFLKPTFKNFFTLVSEKALDRESQAEYNIT
ITVTDLGTPRLKTEYNITVLLSDVNDNAPTFTQTSYTLFVRENNSPALHIGSVSATDRDS
GTNAQVNYSLLPPQDRHLPLASLVSINADNGHLFALRSLDYEALQEFEFRVGATDRGSPA
LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKHRLVVLVKDNGEPPRSATATLHV
LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVLLFVAVRLCRRSRAA
SVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGGSGTNEFKFLKPIIPNFQVHDTG
RNMGEIENFRNSFGLNIQ

External Links

GenBank ID Protein

5457035

UniProtKB/Swiss-Prot ID

Q9Y5E9

UniProtKB/Swiss-Prot Entry Name

PCDBE_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]