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Identification
HMDB Protein ID HMDBP07905
Secondary Accession Numbers
  • 13616
Name Protocadherin beta-15
Synonyms
  1. PCDH-beta-15
Gene Name PCDHB15
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
plasma membrane
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Process
cell adhesion
cellular process
cell-cell adhesion
homophilic cell adhesion
Cellular Location
  1. Cell membrane
  2. Single-pass type I membrane protein
Gene Properties
Chromosome Location Chromosome:5
Locus 5q31
SNPs PCDHB15
Gene Sequence
>2364 bp
ATGGAGCCTGCAGGGGAGCGCTTTCCCGAACAAAGGCAAGTCCTGATTCTCCTTCTTTTA
CTGGAAGTGACTCTGGCAGGCTGGGAACCCCGTCGCTATTCTGTGATGGAGGAAACAGAG
AGAGGTTCTTTTGTAGCCAACCTGGCCAATGACCTAGGGCTGGGAGTGGGGGAGCTAGCC
GAGCGGGGAGCCCGGGTAGTTTCTGAGGATAACGAACAAGGCTTGCAGCTTGATCTGCAG
ACCGGGCAGTTGATATTAAATGAGAAGCTGGACCGGGAGAAGCTGTGTGGCCCTACTGAG
CCCTGTATAATGCATTTCCAAGTGTTACTGAAAAAACCTTTGGAAGTATTTCGAGCTGAA
CTACTAGTGACAGACATAAACGATCATTCTCCTGAGTTTCCTGAAAGAGAAATGACCCTG
AAAATCCCAGAAACTAGCTCCCTTGGGACTGTGTTTCCTCTGAAAAAAGCTCGGGACTTG
GACGTGGGCAGCAATAATGTTCAAAACTACAATATTTCTCCCAATTCTCATTTCCATGTT
TCCACTCGCACCCGAGGGGATGGCAGGAAATACCCAGAGCTGGTGCTGGACACAGAACTG
GATCGCGAGGAGCAGGCCGAGCTCAGATTAACCTTGACAGCGGTGGACGGTGGCTCTCCA
CCCCGATCTGGCACCGTCCAGATCCTCATCTTGGTCTTGGACGCCAATGACAATGCCCCG
GAGTTTGTGCAGGCGCTCTACGAGGTGCAGGTCCCAGAGAACAGCCCAGTAGGCTCCCTA
GTTGTCAAGGTCTCTGCTAGGGATTTAGACACTGGGACAAATGGAGAGATATCATACTCC
CTTTATTACAGCTCTCAGGAGATAGACAAACCTTTTGAGCTAAGCAGCCTTTCAGGAGAA
ATTCGACTAATTAAAAAACTAGATTTTGAGACAATGTCTTCGTATGATCTAGATATAGAG
GCATCTGATGGCGGGGGACTTTCTGGAAAATGCTCTGTCTCTGTTAAGGTGCTGGATGTT
AACGATAACTTCCCGGAACTAAGTATTTCATCACTTACCAGCCCTATTCCCGAGAATTCT
CCAGAGACAGAAGTGGCCCTGTTTAGGATTAGAGACCGAGACTCTGGGGAAAATGGAAAA
ATGATTTGCTCAATTCAGGATGATGTTCCTTTTAAGCTAAAACCTTCTGTTGAGAATTTC
TACAGGCTGGTAACAGAAGGGGCGCTGGACAGAGAGACCAGAGCCGAGTACAACATCACC
ATCACCATCACAGACTTGGGGACTCCAAGGCTGAAAACCGAGCAGAGCATAACCGTGCTG
GTGTCGGACGTCAATGACAACGCCCCCGCCTTCACCCAAACCTCCTACACCCTGTTCGTC
CGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGTGTCAGCGCCACAGACAGAGACTCG
GGCACCAACGCCCAGGTCACCTACTCGCTGCTGCCGCCCCGGGACCCGCACCTGCCCCTC
ACCTCCCTGGTCTCCATTAACACGGACAACGGCCACCTGTTCGCTCTCCAGTCGCTGGAC
TACGAGGCCCTGCAGGCTTTCGAGTTCCGCGTGGGCGCCACAGACCGCGGCTTCCCGGCG
CTGAGCAGCGAGGCGCTGGTGCGAGTGCTGGTGCTGGACGCCAACGACAACTCGCCCTTC
GTGCTGTACCCGCTGCAGAACGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCGGCC
GAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAACGCC
TGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTGTTCGGCGTGTGGGCGCAC
AATGGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGTGGCCAAGCACAGGCTA
GTGGTGCTGGTCAAGGACAATGGCGAGCCTCCGCGCTCGGCCACCGCCACGCTGCAAGTG
CTCCTGGTGGACGGCTTCTCTCAGCCCTACCTGCCGCTCCCAGAGGCGGCCCCGGCCCAA
GCCCAGGCCGACTCGCTTACCGTCTACCTGGTGGTGGCATTGGCCTCGGTGTCTTCGCTC
TTCCTCTTCTCGGTGTTCCTGTTCGTGGCAGTGCGGCTGTGCAGGAGGAGCAGGGCGGCC
TCAGTGGGTCGCTGCTCGGTGCCCGAGGGCCCCTTTCCAGGGCATCTGGTGGACGTGAGC
GGCACCGGGACCCTTTCCCAGAGCTACCAGTACGAGGTGTGTCTGACGGGAGGCTCTGAA
AGTAATGATTTCAAGTTCTTGAAGCCTATATTCCCAAATATTGTAAGCCAGGACTCTAGG
AGGAAATCAGAATTTCTAGAATAA
Protein Properties
Number of Residues 787
Molecular Weight 86328.4
Theoretical pI 4.46
Pfam Domain Function
Signals
  • 1-26
Transmembrane Regions
  • 691-711
Protein Sequence
>Protocadherin beta-15
MEPAGERFPEQRQVLILLLLLEVTLAGWEPRRYSVMEETERGSFVANLANDLGLGVGELA
ERGARVVSEDNEQGLQLDLQTGQLILNEKLDREKLCGPTEPCIMHFQVLLKKPLEVFRAE
LLVTDINDHSPEFPEREMTLKIPETSSLGTVFPLKKARDLDVGSNNVQNYNISPNSHFHV
STRTRGDGRKYPELVLDTELDREEQAELRLTLTAVDGGSPPRSGTVQILILVLDANDNAP
EFVQALYEVQVPENSPVGSLVVKVSARDLDTGTNGEISYSLYYSSQEIDKPFELSSLSGE
IRLIKKLDFETMSSYDLDIEASDGGGLSGKCSVSVKVLDVNDNFPELSISSLTSPIPENS
PETEVALFRIRDRDSGENGKMICSIQDDVPFKLKPSVENFYRLVTEGALDRETRAEYNIT
ITITDLGTPRLKTEQSITVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDS
GTNAQVTYSLLPPRDPHLPLTSLVSINTDNGHLFALQSLDYEALQAFEFRVGATDRGFPA
LSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQNA
WLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDVAKHRLVVLVKDNGEPPRSATATLQV
LLVDGFSQPYLPLPEAAPAQAQADSLTVYLVVALASVSSLFLFSVFLFVAVRLCRRSRAA
SVGRCSVPEGPFPGHLVDVSGTGTLSQSYQYEVCLTGGSESNDFKFLKPIFPNIVSQDSR
RKSEFLE
GenBank ID Protein 5457037
UniProtKB/Swiss-Prot ID Q9Y5E8
UniProtKB/Swiss-Prot Entry Name PCDBF_HUMAN
PDB IDs Not Available
GenBank Gene ID AF152494
GeneCard ID PCDHB15
GenAtlas ID PCDHB15
HGNC ID HGNC:8686
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Wu Q, Maniatis T: A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell. 1999 Jun 11;97(6):779-90. [PubMed:10380929 ]
  4. Vanhalst K, Kools P, Vanden Eynde E, van Roy F: The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number. FEBS Lett. 2001 Apr 20;495(1-2):120-5. [PubMed:11322959 ]