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Showing Protein Bone marrow proteoglycan (HMDBP07954)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07954
Secondary Accession Numbers
  • 13665
Name Bone marrow proteoglycan
Synonyms
  1. BMPG
  2. EMBP
  3. Eosinophil granule major basic protein
  4. MBP
  5. Pregnancy-associated major basic protein
  6. Proteoglycan 2
Gene Name PRG2
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Cytotoxin and helminthotoxin. Also induces non-cytolytic histamine release from human basophils. Involved in antiparasitic defense mechanisms and immune hypersensitivity reactions. The proform acts as a proteinase inhibitor, reducing the activity of PAPPA
Pathways Not Available
Reactions Not Available
GO Classification
Function
binding
Process
immune system process
immune response
Cellular Location
  1. secretory vesicle
  2. Eosinophil granule major basic protein:Cytoplasmic vesicle
Gene Properties
Chromosome Location Chromosome:1
Locus 11q12
SNPs PRG2
Gene Sequence 
>669 bp
ATGAAACTCCCCCTACTTCTGGCTCTTCTATTTGGGGCAGTTTCTGCTCTTCATCTAAGG
TCTGAGACTTCCACCTTTGAGACCCCTTTGGGTGCTAAGACGCTGCCTGAGGATGAGGAG
ACACCAGAGCAGGAGATGGAGGAGACCCCTTGCAGGGAGCTGGAGGAAGAGGAGGAGTGG
GGCTCTGGAAGTGAAGATGCCTCCAAGAAAGATGGGGCTGTTGAGTCTATCTCAGTGCCA
GATATGGTGGACAAAAACCTTACGTGTCCTGAGGAAGAGGACACAGTAAAAGTGGTGGGC
ATCCCTGGGTGCCAGACCTGCCGCTACCTCCTGGTGAGAAGTCTTCAGACGTTTAGTCAA
GCTTGGTTTACTTGCCGGAGGTGCTACAGGGGCAACCTGGTTTCCATCCACAACTTCAAT
ATTAATTATCGAATCCAGTGTTCTGTCAGCGCGCTCAACCAGGGTCAAGTCTGGATTGGA
GGCAGGATCACAGGCTCGGGTCGCTGCAGACGCTTTCAGTGGGTTGACGGCAGCCGCTGG
AACTTTGCGTACTGGGCTGCTCACCAGCCCTGGTCCCGCGGTGGTCACTGCGTGGCCCTG
TGTACCCGAGGAGGCTACTGGCGTCGAGCCCACTGCCTCAGAAGACTTCCTTTCATCTGT
TCCTACTGA
Protein Properties
Number of Residues 222
Molecular Weight 25205.3
Theoretical pI 6.75
Pfam Domain Function
Signals
  • 1-16
Transmembrane Regions
  • None
Protein Sequence 
>Bone marrow proteoglycan
MKLPLLLALLFGAVSALHLRSETSTFETPLGAKTLPEDEETPEQEMEETPCRELEEEEEW
GSGSEDASKKDGAVESISVPDMVDKNLTCPEEEDTVKVVGIPGCQTCRYLLVRSLQTFSQ
AWFTCRRCYRGNLVSIHNFNINYRIQCSVSALNQGQVWIGGRITGSGRCRRFQWVDGSRW
NFAYWAAHQPWSRGGHCVALCTRGGHWRRAHCLRRLPFICSY
GenBank ID Protein 34476
UniProtKB/Swiss-Prot ID P13727
UniProtKB/Swiss-Prot Entry Name PRG2_HUMAN
PDB IDs
GenBank Gene ID Y00809
GeneCard ID PRG2
GenAtlas ID PRG2
HGNC ID HGNC:9362
References
General References
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  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
  4. Ulrich M, Petre A, Youhnovski N, Promm F, Schirle M, Schumm M, Pero RS, Doyle A, Checkel J, Kita H, Thiyagarajan N, Acharya KR, Schmid-Grendelmeier P, Simon HU, Schwarz H, Tsutsui M, Shimokawa H, Bellon G, Lee JJ, Przybylski M, Doring G: Post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase. J Biol Chem. 2008 Oct 17;283(42):28629-40. doi: 10.1074/jbc.M801196200. Epub 2008 Aug 11. [PubMed:18694936 ]
  5. Gabay JE, Scott RW, Campanelli D, Griffith J, Wilde C, Marra MN, Seeger M, Nathan CF: Antibiotic proteins of human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A. 1989 Jul;86(14):5610-4. [PubMed:2501794 ]
  6. Oxvig C, Haaning J, Kristensen L, Wagner JM, Rubin I, Stigbrand T, Gleich GJ, Sottrup-Jensen L: Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma. J Biol Chem. 1995 Jun 9;270(23):13645-51. [PubMed:7539791 ]
  7. Barker RL, Gleich GJ, Pease LR: Acidic precursor revealed in human eosinophil granule major basic protein cDNA. J Exp Med. 1988 Oct 1;168(4):1493-8. [PubMed:3171483 ]
  8. Barker RL, Loegering DA, Arakawa KC, Pease LR, Gleich GJ: Cloning and sequence analysis of the human gene encoding eosinophil major basic protein. Gene. 1990 Feb 14;86(2):285-9. [PubMed:2323577 ]
  9. McGrogan M, Simonsen C, Scott R, Griffith J, Ellis N, Kennedy J, Campanelli D, Nathan C, Gabay J: Isolation of a complementary DNA clone encoding a precursor to human eosinophil major basic protein. J Exp Med. 1988 Dec 1;168(6):2295-308. [PubMed:3199069 ]
  10. Yoshimatsu K, Ohya Y, Shikata Y, Seto T, Hasegawa Y, Tanaka I, Kawamura T, Kitoh K, Toyoshima S, Osawa T: Purification and cDNA cloning of a novel factor produced by a human T-cell hybridoma: sequence homology with animal lectins. Mol Immunol. 1992 Apr;29(4):537-46. [PubMed:1565101 ]
  11. Li MS, Sun L, Satoh T, Fisher LM, Spry CJ: Human eosinophil major basic protein, a mediator of allergic inflammation, is expressed by alternative splicing from two promoters. Biochem J. 1995 Feb 1;305 ( Pt 3):921-7. [PubMed:7531438 ]
  12. Shikata Y, Hayashi Y, Yoshimatsu K, Ohya Y, Seto T, Fukushima K, Yoshida Y: Pro-major basic protein has three types of sugar chains at the pro-portion. Biochim Biophys Acta. 1993 Jun 4;1163(3):243-9. [PubMed:8507662 ]
  13. Oxvig C, Sand O, Kristensen T, Gleich GJ, Sottrup-Jensen L: Circulating human pregnancy-associated plasma protein-A is disulfide-bridged to the proform of eosinophil major basic protein. J Biol Chem. 1993 Jun 15;268(17):12243-6. [PubMed:7685339 ]
  14. Wasmoen TL, Bell MP, Loegering DA, Gleich GJ, Prendergast FG, McKean DJ: Biochemical and amino acid sequence analysis of human eosinophil granule major basic protein. J Biol Chem. 1988 Sep 5;263(25):12559-63. [PubMed:3410852 ]
  15. Weller PF, Ackerman SJ, Smith JA: Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase. J Leukoc Biol. 1988 Jan;43(1):1-4. [PubMed:3422083 ]
  16. Kristensen T, Oxvig C, Sand O, Moller NP, Sottrup-Jensen L: Amino acid sequence of human pregnancy-associated plasma protein-A derived from cloned cDNA. Biochemistry. 1994 Feb 15;33(6):1592-8. [PubMed:7508748 ]
  17. Wasmoen TL, McKean DJ, Benirschke K, Coulam CB, Gleich GJ: Evidence of eosinophil granule major basic protein in human placenta. J Exp Med. 1989 Dec 1;170(6):2051-63. [PubMed:2584934 ]
  18. Oxvig C, Haaning J, Hojrup P, Sottrup-Jensen L: Location and nature of carbohydrate groups in proform of human major basic protein isolated from pregnancy serum. Biochem Mol Biol Int. 1994 May;33(2):329-36. [PubMed:7524900 ]
  19. Oxvig C, Gleich GJ, Sottrup-Jensen L: Localization of disulfide bridges and free sulfhydryl groups in human eosinophil granule major basic protein. FEBS Lett. 1994 Mar 21;341(2-3):213-7. [PubMed:8137941 ]
  20. Bonno M, Oxvig C, Kephart GM, Wagner JM, Kristensen T, Sottrup-Jensen L, Gleich GJ: Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta. Lab Invest. 1994 Oct;71(4):560-6. [PubMed:7526035 ]
  21. Overgaard MT, Oxvig C, Christiansen M, Lawrence JB, Conover CA, Gleich GJ, Sottrup-Jensen L, Haaning J: Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues. Biol Reprod. 1999 Oct;61(4):1083-9. [PubMed:10491647 ]
  22. Overgaard MT, Haaning J, Boldt HB, Olsen IM, Laursen LS, Christiansen M, Gleich GJ, Sottrup-Jensen L, Conover CA, Oxvig C: Expression of recombinant human pregnancy-associated plasma protein-A and identification of the proform of eosinophil major basic protein as its physiological inhibitor. J Biol Chem. 2000 Oct 6;275(40):31128-33. [PubMed:10913121 ]
  23. Overgaard MT, Sorensen ES, Stachowiak D, Boldt HB, Kristensen L, Sottrup-Jensen L, Oxvig C: Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment. J Biol Chem. 2003 Jan 24;278(4):2106-17. Epub 2002 Nov 5. [PubMed:12421832 ]
  24. Swaminathan GJ, Weaver AJ, Loegering DA, Checkel JL, Leonidas DD, Gleich GJ, Acharya KR: Crystal structure of the eosinophil major basic protein at 1.8 A. An atypical lectin with a paradigm shift in specificity. J Biol Chem. 2001 Jul 13;276(28):26197-203. Epub 2001 Apr 23. [PubMed:11319227 ]