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Identification
HMDB Protein ID HMDBP07970
Secondary Accession Numbers
  • 13681
Name Ras-specific guanine nucleotide-releasing factor 2
Synonyms
  1. Ras guanine nucleotide exchange factor 2
  2. Ras-GRF2
Gene Name RASGRF2
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
guanyl-nucleotide exchange factor activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
signal transduction
intracellular signal transduction
small gtpase mediated signal transduction
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. Peripheral membrane protein
  4. Peripheral membrane protein
  5. Endoplasmic reticulum membrane
Gene Properties
Chromosome Location Chromosome:5
Locus 5q13
SNPs RASGRF2
Gene Sequence
>3711 bp
ATGCAGAAGAGCGTGCGCTACAACGAGGGGCACGCCCTGTACCTGGCCTTTCTGGCGCGC
AAGGAGGGCACCAAGCGCGGCTTCCTGAGTAAGAAGACGGCCGAGGCGAGCCGCTGGCAC
GAGAAGTGGTTCGCCCTCTACCAGAATGTGCTCTTCTACTTCGAGGGCGAGCAGAGCTGC
CGCCCGGCGGGCATGTACCTCCTGGAGGGCTGCAGCTGCGAACGAACGCCCGCGCCACCC
AGGGCCGGCGCCGGGCAGGGAGGCGTCCGAGACGCGCTGGACAAGCAGTATTACTTTACT
GTTCTTTTTGGCCATGAAGGTCAGAAGCCACTGGAGCTGCGCTGTGAGGAGGAGCAGGAT
GGTAAAGAGTGGATGGAGGCCATTCACCAAGCCAGTTATGCAGACATTTTGATTGAGAGG
GAAGTATTAATGCAGAAGTACATTCATCTAGTTCAGATCGTAGAGACAGAAAAAATTGCA
GCTAACCAACTCCGACATCAACTTGAAGATCAAGACACAGAAATCGAAAGGCTTAAATCA
GAGATTATTGCTCTTAATAAAACCAAAGAACGAATGCGACCTTACCAAAGCAACCAAGAA
GACGAAGATCCAGACATCAAGAAGATTAAAAAGGTTCAGAGCTTCATGCGAGGATGGTTG
TGCAGAAGGAAATGGAAGACCATCGTGCAGGATTACATTTGTTCTCCTCATGCTGAAAGT
ATGAGGAAGAGAAACCAGATTGTGTTCACCATGGTGGAGGCAGAGTCAGAGTACGTTCAC
CAGCTCTACATCCTGGTCAATGGCTTTCTCCGGCCCCTGCGTATGGCCGCCAGCTCCAAG
AAGCCCCCCATCAGCCACGACGACGTCAGCAGTATTTTTCTTAACAGTGAAACAATCATG
TTTCTTCATGAAATATTTCATCAAGGACTAAAGGCAAGGATAGCAAACTGGCCCACTTTA
ATTTTAGCTGATCTGTTTGATATTTTGCTCCCCATGCTGAACATTTATCAAGAATTTGTG
CGTAATCACCAGTACAGCCTGCAAGTTCTCGCCAATTGTAAGCAAAACAGAGATTTTGAC
AAACTCTTAAAACAGTATGAAGCCAATCCAGCCTGTGAGGGGAGGATGCTGGAGACATTC
TTGACCTATCCCATGTTCCAGATCCCCAGATATATCATCACACTCCATGAGCTCCTTGCT
CACACACCCCATGAGCATGTGGAAAGGAAAAGCCTGGAGTTTGCCAAATCAAAGCTAGAG
GAACTATCCAGAGTAATGCACGATGAAGTCAGCGACACTGAAAACATAAGGAAAAACCTT
GCCATCGAAAGAATGATCGTGGAGGGCTGTGACATCTTGCTGGACACCAGCCAAACGTTC
ATCCGCCAAGGTTCTCTTATTCAAGTACCTTCCGTTGAGAGGGGGAAACTTAGTAAAGTT
CGCCTGGGTTCGTTGTCTTTGAAAAAGGAAGGAGAGAGACAATGCTTCTTATTTACAAAA
CACTTTTTAATATGTACAAGAAGTTCAGGAGGGAAGCTTCATCTGCTCAAGACAGGTGGG
GTTCTGTCTCTAATAGACTGCACATTGATTGAGGAGCCAGATGCAAGCGATGATGACTCT
AAAGGTTCTGGGCAAGTGTTTGGGCACCTGGATTTTAAAATAGTGGTGGAGCCTCCTGAC
CGTGCCGCCTTCACTGTTGTCTTGTTAGCACCCTCACGCCAGGAGAAAGCTGCCTGGATG
AGTGACATCAGTCAGTGTGTGGACAATATACGATGTAATGGTTTAATGACTATAGTGTTT
GAAGAGAATTCCAAAGTCACTGTGCCACATATGATTAAGTCTGATGCCCGTCTTCATAAA
GACGACACTGACATTTGCTTCAGTAAAACACTCAACTCCTGCAAAGTGCCCCAGATCCGT
TATGCCAGCGTGGAGCGCCTCTTGGAACGACTGACAGACTTGCGGTTTCTTAGTATTGAT
TTCCTCAACACCTTTCTGCACACCTATCGTATTTTCACTACTGCCGCTGTGGTGCTGGGG
AAACTCTCCGACATATACAAGAGGCCTTTCACCTCCATCCCTGTCAGGTCATTGGAATTG
TTTTTTGCTACCAGCCAGAACAACAGAGGTGAACATTTGGTGGATGGCAAATCCCCACGT
CTGTGTCGCAAATTCTCTTCCCCGCCACCACTGGCTGTGTCCAGAACATCTTCCCCAGTG
AGGGCCAGAAAGCTGTCTTTGACTTCTCCCTTGAACTCAAAGATAGGAGCATTGGACCTG
ACAACTTCCAGCAGTCCCACCACCACCACCCAGAGTCCCGCTGCGTCTCCACCACCACAC
ACTGGTCAGATACCACTGGATCTCAGCAGAGGCCTCTCTTCTCCAGAGCAAAGCCCGGGA
ACGGTAGAAGAGAATGTCGATAACCCACGCGTGGATCTGTGTAACAAGCTAAAACGAAGT
ATTCAAAAAGCAGTCCTAGAGTCTGCACCAGCGGACCGAGCAGGAGTGGAAAGCTCCCCT
GCAGCGGACACCACAGAACTTTCACCTTGCAGATCCCCCTCAACTCCTCGGCACCTCCGC
TATCGACAGCCTGGAGGACAGACGGCGGACAATGCCCACTGCTCTGTTTCACCGGCTTCT
GCTTTTGCAATAGCCACAGCTGCAGCAGGACATGGGAGTCCACCAGGCTTTAACAACACC
GAGAGAACATGTGATAAAGAGTTTATTATACGGAGAACGGCTACCAATCGAGTTCTGAAC
GTCCTCCGTCACTGGGTCTCAAAGCACGCACAGGATTTCGAACTCAACAATGAACTAAAG
ATGAATGTCCTAAATTTGCTAGAAGAAGTTTTGCGAGACCCAGACCTTCTTCCCCAAGAA
AGGAAAGCCGCCGCGAATATCCTCAGGGCCCTTTCACAAGATGACCAAGATGACATCCAC
CTAAAATTAGAGGATATAATTCAAATGACTGACTGCATGAAGGCCGAATGCTTTGAGTCC
TTGTCGGCCATGGAGCTGGCAGAACAGATCACCCTCCTGGACCATGTCATTTTCAGAAGC
ATTCCCTACGAGGAGTTTCTTGGGCAGGGGTGGATGAAGCTGGATAAAAACGAAAGAACT
CCTTACATTATGAAAACCAGCCAACACTTCAATGACATGAGTAACCTGGTGGCCTCCCAG
ATAATGAACTATGCTGATGTCAGCTCCCGTGCCAACGCCATCGAGAAATGGGTGGCAGTG
GCGGACATCTGCCGATGCCTGCACAACTACAACGGCGTGCTGGAGATCACCTCGGCCTTA
AACAGAAGTGCCATCTACAGGCTGAAGAAAACCTGGGCCAAGGTCTCTAAGCAGACAAAA
GCTCTAATGGACAAACTTCAAAAGACTGTTTCCTCTGAAGGAAGATTTAAAAATCTTAGA
GAAACCCTTAAAAATTGTAACCCTCCTGCAGTTCCTTATCTTGGGATGTACTTGACAGAC
CTGGCATTTATTGAAGAAGGAACACCAAACTTTACTGAGGAAGGCCTTGTCAATTTCTCC
AAAATGAGAATGATATCACACATCATCAGAGAGATACGCCAGTTCCAGCAGACTTCCTAC
AGAATAGATCATCAGCCAAAGGTCGCACAGTACTTGCTTGACAAAGACCTTATCATAGAT
GAAGATACGCTATATGAGCTGTCACTCAAAATTGAACCTCGACTCCCTGCT
Protein Properties
Number of Residues 1237
Molecular Weight 140762.8
Theoretical pI 7.56
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Ras-specific guanine nucleotide-releasing factor 2
MQKSVRYNEGHALYLAFLARKEGTKRGFLSKKTAEASRWHEKWFALYQNVLFYFEGEQSC
RPAGMYLLEGCSCERTPAPPRAGAGQGGVRDALDKQYYFTVLFGHEGQKPLELRCEEEQD
GKEWMEAIHQASYADILIEREVLMQKYIHLVQIVETEKIAANQLRHQLEDQDTEIERLKS
EIIALNKTKERMRPYQSNQEDEDPDIKKIKKVQSFMRGWLCRRKWKTIVQDYICSPHAES
MRKRNQIVFTMVEAESEYVHQLYILVNGFLRPLRMAASSKKPPISHDDVSSIFLNSETIM
FLHEIFHQGLKARIANWPTLILADLFDILLPMLNIYQEFVRNHQYSLQVLANCKQNRDFD
KLLKQYEANPACEGRMLETFLTYPMFQIPRYIITLHELLAHTPHEHVERKSLEFAKSKLE
ELSRVMHDEVSDTENIRKNLAIERMIVEGCDILLDTSQTFIRQGSLIQVPSVERGKLSKV
RLGSLSLKKEGERQCFLFTKHFLICTRSSGGKLHLLKTGGVLSLIDCTLIEEPDASDDDS
KGSGQVFGHLDFKIVVEPPDAAAFTVVLLAPSRQEKAAWMSDISQCVDNIRCNGLMTIVF
EENSKVTVPHMIKSDARLHKDDTDICFSKTLNSCKVPQIRYASVERLLERLTDLRFLSID
FLNTFLHTYRIFTTAAVVLGKLSDIYKRPFTSIPVRSLELFFATSQNNRGEHLVDGKSPR
LCRKFSSPPPLAVSRTSSPVRARKLSLTSPLNSKIGALDLTTSSSPTTTTQSPAASPPPH
TGQIPLDLSRGLSSPEQSPGTVEENVDNPRVDLCNKLKRSIQKAVLESAPADRAGVESSP
AADTTELSPCRSPSTPRHLRYRQPGGQTADNAHCSVSPASAFAIATAAAGHGSPPGFNNT
ERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPDLLPQE
RKAAANILRALSQDDQDDIHLKLEDIIQMTDCMKAECFESLSAMELAEQITLLDHVIFRS
IPYEEFLGQGWMKLDKNERTPYIMKTSQHFNDMSNLVASQIMNYADVSSRANAIEKWVAV
ADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSKQTKALMDKLQKTVSSEGRFKNLR
ETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSY
RIDHQPKVAQYLLDKDLIIDEDTLYELSLKIEPRLPA
GenBank ID Protein 2522208
UniProtKB/Swiss-Prot ID O14827
UniProtKB/Swiss-Prot Entry Name RGRF2_HUMAN
PDB IDs Not Available
GenBank Gene ID AF023130
GeneCard ID RASGRF2
GenAtlas ID RASGRF2
HGNC ID HGNC:9876
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]
  3. Anborgh PH, Qian X, Papageorge AG, Vass WC, DeClue JE, Lowy DR: Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Mol Cell Biol. 1999 Jul;19(7):4611-22. [PubMed:10373510 ]
  4. Lutchman M, Kim AC, Cheng L, Whitehead IP, Oh SS, Hanspal M, Boukharov AA, Hanada T, Chishti AH: Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein kinase pathways. Eur J Biochem. 2002 Jan;269(2):638-49. [PubMed:11856323 ]
  5. Rabiet MJ, Tardif M, Braun L, Boulay F: Inhibitory effects of a dominant-interfering form of the Rho-GTPase Cdc42 in the chemoattractant-elicited signaling pathways leading to NADPH oxidase activation in differentiated HL-60 cells. Blood. 2002 Sep 1;100(5):1835-44. [PubMed:12176907 ]
  6. Kesavapany S, Amin N, Zheng YL, Nijhara R, Jaffe H, Sihag R, Gutkind JS, Takahashi S, Kulkarni A, Grant P, Pant HC: p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons. J Neurosci. 2004 May 5;24(18):4421-31. [PubMed:15128856 ]
  7. Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Munoz MT, Egea G, Lafarga M, Crespo P: Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Mol Cell Biol. 2004 Feb;24(4):1516-30. [PubMed:14749369 ]