Human Metabolome Database: Showing Protein Sarcoplasmic reticulum histidine-rich calcium-binding protein (HMDBP08007)

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Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification
HMDB Protein ID	HMDBP08007
Secondary Accession Numbers	13718
Name	Sarcoplasmic reticulum histidine-rich calcium-binding protein
Synonyms	Not Available
Gene Name	HRC
Protein Type	Unknown
Biological Properties
General Function	Involved in calcium ion binding
Specific Function	May play a role in the regulation of calcium sequestration or release in the SR of skeletal and cardiac muscle
Pathways	Not Available
Reactions	Not Available
GO Classification	Not Available
Cellular Location	Sarcoplasmic reticulum lumen
Gene Properties
Chromosome Location	Chromosome:1
Locus	19q13.3
SNPs	HRC
Gene Sequence	>2100 bp ATGGGCCACCATAGGCCATGGCTGCACGCTTCTGTCCTCTGGGCTGGGGTGGCCAGCCTG CTCCTCCCCCCGGCCATGACCCAGCAGCTCAGAGGGGATGGGCTAGGCTTCAGAAACCGG AACAACAGCACTGGAGTCGCCGGGCTCTCCGAGGAGGCATCAGCAGAGCTTCGCCACCAC CTCCACAGCCCTAGAGACCATCCAGATGAGAACAAGGATGTTTCCACAGAGAATGGGCAT CATTTCTGGAGCCACCCAGACCGTGAAAAGGAGGATGAAGATGTCTCCAAGGAATATGGG CACCTACTCCCAGGCCACAGGTCCCAAGACCACAAAGTCGGAGATGAGGGTGTCTCAGGT GAGGAGGTCTTTGCAGAGCATGGTGGGCAGGCCCGTGGGCACAGAGGCCACGGGAGTGAA GACACGGAAGACTCAGCTGAGCACAGGCACCACCTCCCCAGCCACAGGAGCCACAGCCAT CAAGACGAGGATGAGGATGAAGTTGTGTCCAGTGAGCATCACCATCATATCCTCAGGCAT GGACACCGAGGCCATGATGGGGAAGATGATGAAGGAGAAGAGGAGGAGGAGGAGGAGGAG GAGGAAGAGGAGGCCTCCACTGAGTATGGACACCAGGCCCACAGGCACCGAGGCCATGGG AGTGAAGAGGATGAGGATGTCTCAGATGGACACCATCATCATGGCCCCAGCCACAGGCAC CAAGGCCATGAAGAAGATGACGATGATGATGATGATGATGATGATGATGATGATGATGAT GATGTCTCCATTGAATATAGACACCAGGCTCACAGGCACCAAGGCCACGGGATTGAAGAG GATGAAGATGTCTCAGATGGACACCATCATCGCGACCCCAGCCACAGGCACCGAAGCCAT GAAGAAGATGACAATGATGATGATGATGTCTCCACTGAGTATGGACACCAGGCCCACAGG CACCAAGACCACAGAAAGGAAGAGGTTGAGGCTGTCTCAGGTGAACACCACCATCATGTC CCTGACCACAGGCACCAAGGCCACAGAGACGAGGAAGAAGATGAGGATGTGTCCACTGAA CGTTGGCACCAGGGTCCCCAACATGTCCACCATGGCCTTGTAGATGAGGAAGAGGAAGAA GAGGAGATCACAGTCCAGTTCGGCCACTATGTTGCAAGCCACCAACCTCGAGGCCACAAG AGTGATGAAGAGGACTTCCAAGATGAGTATAAAACAGAAGTCCCTCACCATCACCACCAC AGAGTCCCCAGGGAGGAAGATGAGGAGGTCTCTGCTGAGCTTGGCCACCAGGCCCCCAGC CACAGGCAAAGCCACCAAGATGAAGAAACTGGCCATGGTCAAAGAGGGTCCATCAAAGAG ATGAGCCATCACCCCCCAGGACACACAGTGGTCAAGGATAGAAGCCATTTGAGGAAGGAT GATTCTGAGGAGGAAAAGGAGAAGGAAGAGGACCCCGGCTCCCATGAGGAAGACGATGAA AGTTCAGAGCAGGGAGAGAAAGGCACCCATCATGGCAGCCGGGACCAGGAAGATGAGGAG GATGAGGAGGAAGGTCATGGCCTCAGCCTGAACCAGGAGGAGGAAGAAGAGGAAGACAAG GAGGAGGAGGAGGAGGAAGAAGACGAGGAGAGGAGGGAAGAGAGGGCTGAGGTTGGGGCC CCACTGAGCCCAGACCACAGCGAGGAGGAAGAGGAGGAGGAGGAGGGGCTGGAGGAAGAT GAGCCCCGCTTCACCATCATCCCCAACCCACTGGACAGGAGAGAGGAGGCTGGAGGTGCC TCCAGCGAGGAGGAAAGCGGTGAGGACACAGGTCCACAGGATGCTCAGGAGTATGGGAAC TACCAGCCAGGGTCCCTGTGTGGCTACTGCTCCTTCTGCAATCGATGCACTGAATGTGAG AGCTGTCACTGTGATGAGGAGAACATGGGTGAGCACTGCGACCAGTGCCAGCACTGTCAG TTCTGCTATCTCTGCCCGCTGGTCTGCGAAACGGTCTGCGCTCCAGGAAGCTACGTTGAC TATTTCTCCTCGTCCCTTTATCAGGCCCTGGCAGACATGCTGGAAACGCCGGAACCCTGA
Protein Properties
Number of Residues	699
Molecular Weight	80243.5
Theoretical pI	4.36
Pfam Domain Function	Hist_rich_Ca-bd (PF10529 )
Signals	1-28
Transmembrane Regions	None
Protein Sequence	>Sarcoplasmic reticulum histidine-rich calcium-binding protein MGHHRPWLHASVLWAGVASLLLPPAMTQQLRGDGLGFRNRNNSTGVAGLSEEASAELRHH LHSPRDHPDENKDVSTENGHHFWSHPDREKEDEDVSKEYGHLLPGHRSQDHKVGDEGVSG EEVFAEHGGQARGHRGHGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRH GHRGHDGEDDEGEEEEEEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHHHHGPSHRH QGHEEDDDDDDDDDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSDGHHHRDPSHRHRSH EEDDNDDDDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTE RWHQGPQHVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHH RVPREEDEEVSAELGHQAPSHRQSHQDEETGHGQRGSIKEMSHHPPGHTVVKDRSHLRKD DSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDEEEGHGLSLNQEEEEEEDK EEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGA SSEEESGEDTGPQDAQEYGNYQPGSLCGYCSFCNRCTECESCHCDEENMGEHCDQCQHCQ FCYLCPLVCETVCAPGSYVDYFSSSLYQALADMLETPEP
External Links
GenBank ID Protein	46854902
UniProtKB/Swiss-Prot ID	P23327
UniProtKB/Swiss-Prot Entry Name	SRCH_HUMAN
PDB IDs	Not Available
GenBank Gene ID	BC069795
GeneCard ID	HRC
GenAtlas ID	HRC
HGNC ID	HGNC:5178
References
General References	Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ] Hofmann SL, Topham M, Hsieh CL, Francke U: cDNA and genomic cloning of HRC, a human sarcoplasmic reticulum protein, and localization of the gene to human chromosome 19 and mouse chromosome 7. Genomics. 1991 Apr;9(4):656-69. [PubMed:2037293 ]