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Identification
HMDB Protein ID HMDBP08030
Secondary Accession Numbers
  • 13741
Name Synaptotagmin-3
Synonyms
  1. Synaptotagmin III
  2. SytIII
Gene Name SYT3
Protein Type Unknown
Biological Properties
General Function Involved in transporter activity
Specific Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
Pathways Not Available
Reactions Not Available
GO Classification
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
organelle
vesicle
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Single-pass membrane protein
  3. secretory vesicle
  4. synaptic vesicle membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.33
SNPs SYT3
Gene Sequence
>1773 bp
ATGTCAGGAGACTACGAGGATGACCTCTGCCGGCGGGCACTCATCCTGGTCTCGGACCTC
TGTGCGCGGGTCCGAGATGCTGACACCAACGACAGGTGCCAGGAGTTCAATGACCGAATC
CGAGGCTATCCCCGGGGTCCAGATGCAGACATCTCCGTGAGCCTGCTGTCGGTCATCGTG
ACATTCTGTGGCATTGTCCTTCTGGGTGTCTCTCTCTTCGTGTCCTGGAAGTTGTGCTGG
GTGCCCTGGCGGGACAAGGGAGGCTCGGCAGTGGGCGGTGGCCCCCTGCGCAAAGACCTA
GGCCCTGGTGTCGGGCTGGCAGGCCTGGTAGGCGGAGGCGGGCACCACCTGGCGGCTGGC
CTGGGTGGCCATCCTCTGCTGGGCGGCCCACACCACCATGCCCATGCCGCCCACCATCCA
CCCTTTGCTGAGCTGCTGGAGCCAGGCAGCCTGGGGGGTTCTGACACCCCTGAGCCCTCC
TACTTGGACATGGACTCGTATCCAGAGGCTGCAGCAGCAGCAGTGGCCGCTGGGGTCAAA
CCGAGCCAAACATCCCCTGAGCTGCCCTCTGAGGGGGGAGCAGGCTCTGGGTTGCTCCTG
CTGCCCCCCAGTGGTGGGGGCTTGCCCAGTGCCCAGTCACATCAGCAGGTCACAAGCCTG
GCACCCACTACCAGGTACCCAGCCCTGCCCCGACCCCTCACCCAGCAGACTCTGACCTCC
CAGCCGGACCCCAGCAGTGAGGAGCGCCCACCTGCCCTGCCCTTACCCCTGCCTGGAGGC
GAGGAAAAAGCCAAACTCATTGGGCAGATTAAGCCAGAGCTGTACCAGGGGACTGGCCCT
GGTGGCCGGCGGAGCGGTGGGGGCCCAGGCTCTGGAGAGGCAGGCACAGGGGCACCCTGT
GGCCGTATCAGCTTCGCCCTGCGGTACCTCTATGGCTCGGACCAGCTGGTGGTGAGGATC
CTGCAGGCCCTGGACCTCCCTGCCAAGGACTCCAACGGCTTCTCAGACCCCTACGTCAAG
ATCTACCTGCTGCCTGACCGCAAGAAAAAGTTTCAGACCAAGGTGCACAGGAAGACCCTG
AACCCCGTCTTCAATGAGACGTTTCAATTCTCGGTGCCCCTGGCCGAGCTGGCCCAACGC
AAACTGCACTTCAGCGTCTATGACTTTGACCGCTTCTCGCGGCACGACCTCATCGGCCAG
GTGGTGCTGGACAACCTCCTGGAGCTGGCCGAGCAGCCCCCTGACCGCCCGCTCTGGAGG
GACATCGTGGAGGGCGGCTCGGAAAAAGCAGATCTTGGGGAGCTCAACTTCTCACTCTGC
TACCTCCCCACGGCCGGGCGCCTCACCGTGACCATCATCAAAGCCTCTAACCTCAAAGCG
ATGGACCTCACTGGCTTCTCAGACCCCTACGTGAAGGCCTCCCTGATCAGCGAGGGGCGG
CGTCTGAAGAAGCGGAAAACCTCCATCAAGAAGAACACGCTGAACCCCACCTATAATGAG
GCGCTGGTGTTCGACGTGGCCCCCGAGAGCGTGGAGAACGTGGGGCTCAGCATCGCCGTG
GTGGACTACGACTGCATCGGGCACAACGAGGTGATCGGCGTGTGCCGTGTGGGCCCCGAC
GCTGCCGACCCGCACGGCCGCGAGCACTGGGCAGAGATGCTGGCCAATCCCCGCAAGCCC
GTGGAGCACTGGCATCAGCTAGTGGAGGAAAAGACTGTGACCAGCTTCACAAAAGGCAGC
AAAGGACTATCAGAGAAAGAGAACTCCGAGTGA
Protein Properties
Number of Residues 590
Molecular Weight 63303.2
Theoretical pI 6.6
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 55-75
Protein Sequence
>Synaptotagmin-3
MSGDYEDDLCRRALILVSDLCARVRDADTNDRCQEFNDRIRGYPRGPDADISVSLLSVIV
TFCGIVLLGVSLFVSWKLCWVPWRDKGGSAVGGGPLRKDLGPGVGLAGLVGGGGHHLAAG
LGGHPLLGGPHHHAHAAHHPPFAELLEPGSLGGSDTPEPSYLDMDSYPEAAAAAVAAGVK
PSQTSPELPSEGGAGSGLLLLPPSGGGLPSAQSHQQVTSLAPTTRYPALPRPLTQQTLTS
QPDPSSEERPPALPLPLPGGEEKAKLIGQIKPELYQGTGPGGRRSGGGPGSGEAGTGAPC
GRISFALRYLYGSDQLVVRILQALDLPAKDSNGFSDPYVKIYLLPDRKKKFQTKVHRKTL
NPVFNETFQFSVPLAELAQRKLHFSVYDFDRFSRHDLIGQVVLDNLLELAEQPPDRPLWR
DIVEGGSEKADLGELNFSLCYLPTAGRLTVTIIKASNLKAMDLTGFSDPYVKASLISEGR
RLKKRKTSIKKNTLNPTYNEALVFDVAPESVENVGLSIAVVDYDCIGHNEVIGVCRVGPD
AADPHGREHWAEMLANPRKPVEHWHQLVEEKTVTSFTKGSKGLSEKENSE
GenBank ID Protein 13276689
UniProtKB/Swiss-Prot ID Q9BQG1
UniProtKB/Swiss-Prot Entry Name SYT3_HUMAN
PDB IDs
GenBank Gene ID AL136594
GeneCard ID SYT3
GenAtlas ID SYT3
HGNC ID HGNC:11511
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A: Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res. 2001 Mar;11(3):422-35. [PubMed:11230166 ]
  3. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE: The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7. [PubMed:16959974 ]