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Identification
HMDB Protein ID HMDBP08031
Secondary Accession Numbers
  • 13742
Name Synaptotagmin-4
Synonyms
  1. Synaptotagmin IV
  2. SytIV
Gene Name SYT4
Protein Type Unknown
Biological Properties
General Function Involved in transporter activity
Specific Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
Pathways Not Available
Reactions Not Available
GO Classification
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
organelle
vesicle
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Single-pass membrane protein
  3. secretory vesicle
  4. synaptic vesicle membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 18q12.3
SNPs SYT4
Gene Sequence
>1278 bp
ATGGCTCCGATCACCACCAGCCGGGAAGAATTTGATGAAATCCCCACAGTGGTGGGGATC
TTCAGTGCATTTGGCCTGGTCTTCACAGTCTCTCTCTTTGCATGGATCTGCTGTCAGAGA
AAATCATCCAAGTCTAACAAGACTCCTCCATACAAGTTTGTGCATGTGCTTAAGGGAGTT
GATATTTACCCTGAAAACCTAAATAGCAAAAAGAAGTTTGGAGCAGATGATAAAAATGAA
GTAAAGAATAAGCCAGCTGTGCCAAAGAATTCATTGCATCTGGATCTTGAAAAGAGAGAT
CTCAATGGCAATTTTCCCAAAACCAACCTCAAACCTGGCAGTCCTTCTGATCTGGAGAAT
GCAACCCCGAAGCTCTTTTTAGAAGGGGAAAAAGAGTCAGTTTCCCCTGAGAGTTTAAAG
TCCAGCACTTCCCTTACTTCAGAAGAGAAACAAGAGAAGCTGGGAACTCTCTTCTTCTCC
TTAGAATACAACTTCGAGAGAAAAGCATTTGTGGTCAATATCAAGGAAGCCCGTGGCTTG
CCAGCCATGGATGAGCAGTCGATGACCTCTGACCCATATATCAAAATGACGATCCTCCCA
GAGAAGAAGCATAAAGTGAAAACTAGAGTGCTGAGAAAAACCTTGGATCCAGCTTTTGAT
GAGACCTTTACATTCTATGGGATACCCTACACCCAAATCCAAGAATTGGCCTTGCACTTC
ACAATTTTGAGTTTTGACAGGTTTTCAAGAGATGATATCATTGGGGAAGTTCTAATTCCT
CTCTCGGGAATTGAATTATCTGAAGGAAAAATGTTAATGAATAGAGAGATCATCAAGAGA
AATGTTAGGAAGTCTTCAGGACGGGGTGAGTTACTGATCTCTCTCTGCTATCAGTCCACC
ACAAACACTCTAACTGTGGTTGTCTTAAAAGCTCGACATCTGCCTAAATCTGATGTGTCC
GGACTTTCAGATCCCTATGTCAAAGTGAACCTGTACCATGCCAAAAAGAGAATCTCCAAG
AAGAAGACTCATGTGAAGAAATGCACCCCCAATGCAGTGTTCAATGAGCTGTTTGTCTTT
GATATTCCTTGTGAGGGCCTTGAAGATATAAGTGTTGAATTTTTGGTTTTGGATTCTGAA
AGGGGGTCCCGAAATGAGGTAATCGGGCAGTTAGTCTTGGGTGCAGCAGCAGAAGGAACT
GGTGGAGAGCACTGGAAAGAGATCTGTGACTACCCCAGGAGACAAATTGCCAAGTGGCAC
GTGCTCTGTGATGGTTAG
Protein Properties
Number of Residues 425
Molecular Weight 47957.8
Theoretical pI 8.78
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 17-37
Protein Sequence
>Synaptotagmin-4
MAPITTSREEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRKSSKSNKTPPYKFVHVLKGV
DIYPENLNSKKKFGADDKNEVKNKPAVPKNSLHLDLEKRDLNGNFPKTNLKPGSPSDLEN
ATPKLFLEGEKESVSPESLKSSTSLTSEEKQEKLGTLFFSLEYNFERKAFVVNIKEARGL
PAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPAFDETFTFYGIPYTQIQELALHF
TILSFDRFSRDDIIGEVLIPLSGIELSEGKMLMNREIIKRNVRKSSGRGELLISLCYQST
TNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVF
DIPCEGLEDISVEFLVLDSERGSRNEVIGQLVLGAAAEGTGGEHWKEICDYPRRQIAKWH
VLCDG
GenBank ID Protein 24308219
UniProtKB/Swiss-Prot ID Q9H2B2
UniProtKB/Swiss-Prot Entry Name SYT4_HUMAN
PDB IDs
GenBank Gene ID NM_020783.3
GeneCard ID SYT4
GenAtlas ID SYT4
HGNC ID HGNC:11512
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 2000 Feb 28;7(1):65-73. [PubMed:10718198 ]
  3. Ferguson GD, Chen XN, Korenberg JR, Herschman HR: The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. J Biol Chem. 2000 Nov 24;275(47):36920-6. [PubMed:10938284 ]