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Showing Protein Synaptotagmin-7 (HMDBP08034)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP08034
Secondary Accession Numbers
  • 13745
Name Synaptotagmin-7
Synonyms
  1. IPCA-7
  2. Prostate cancer-associated protein 7
  3. Synaptotagmin VII
  4. SytVII
Gene Name SYT7
Protein Type Unknown
Biological Properties
General Function Involved in transporter activity
Specific Function May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis
Pathways Not Available
Reactions Not Available
GO Classification
Component
cytoplasmic vesicle
cytoplasmic membrane-bounded vesicle
coated vesicle
clathrin-coated vesicle
synaptic vesicle
membrane
cell part
organelle
vesicle
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Cytoplasmic vesicle
  2. Single-pass membrane protein
  3. secretory vesicle
  4. synaptic vesicle membrane
Gene Properties
Chromosome Location Chromosome:1
Locus 11q12-q13.1
SNPs SYT7
Gene Sequence 
>1212 bp
ATGTACCGGGACCCGGAGGCGGCCAGCCCAGGGGCGCCCTCGCGCGACGTCCTGCTGGTC
TCTGCCATCATCACCGTCAGCCTTAGCGTCACTGTCGTCCTCTGCGGCCTCTGCCACTGG
TGTCAGCGCAAACTGGGCAAACGCTACAAGAATTCCTTGGAGACGGTGGGCACGCCAGAC
TCAGGGCGTGGGCGCAGTGAGAAGAAGGCTATCAAGTTGCCTGCAGGAGGGAAGGCGGTG
AACACAGCCCCCGTGCCAGGCCAGACACCCCACGATGAGTCCGACCGCCGGACCGAGCCA
CGTTCCTCCGTCTCAGACCTCGTCAACTCCCTCACCAGCGAGATGCTCATGCTCTCCCCA
GGCTCCGAGGAGGATGAGGCCCACGAGGGTTGCAGCCGAGAGAACCTGGGCCGGATCCAG
TTCAGTGTCGGCTACAACTTCCAGGAGTCCACGCTCACCGTGAAGATCATGAAGGCCCAG
GAGCTGCCGGCCAAGGACTTCAGCGGCACCAGCGACCCCTTCGTCAAGATTTACCTGCTG
CCCGACAAGAAGCACAAGCTGGAGACCAAGGTGAAGCGGAAGAACCTGAACCCCCACTGG
AACGAGACCTTCCTCTTTGAAGGTTTTCCCTATGAGAAGGTGGTGCAGAGGATCCTCTAC
CTCCAAGTCCTGGACTATGACCGCTTCAGCCGCAACGACCCCATTGGGGAGGTGTCCATC
CCCCTTAACAAGGTGGACCTGACCCAGATGCAGACCTTCTGGAAGGATCTGAAGCCATGC
AGCGATGGGAGTGGGAGCCGAGGGGAGCTGCTCTTGTCTCTCTGCTACAACCCCTCTGCC
AACTCCATCATCGTGAACATCATCAAAGCCCGGAACCTCAAAGCCATGGACATCGGGGGC
ACATCAGACCCCTACGTGAAGGTATGGCTGATGTACAAGGACAAGCGGGTGGAGAAGAAG
AAGACGGTGACGATGAAGAGGAACCTGAACCCCATCTTCAATGAGTCCTTCGCCTTCGAT
ATCCCCACGGAGAAGCTGAGGGAGACGACCATCATCATCACTGTCATGGACAAGGACAAG
CTCAGCCGCAATGACGTCATCGGCAAGATCTACCTGTCCTGGAAGAGCGGGCCAGGGGAG
GTGAAGCACTGGAAGGACATGATTGCCCGTCCCCGGCAGCCCGTGGCCCAGTGGCACCAG
CTGAAGGCCTGA
Protein Properties
Number of Residues 403
Molecular Weight 45501.0
Theoretical pI 9.74
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 17-37
Protein Sequence 
>Synaptotagmin-7
MYRDPEAASPGAPSRDVLLVSAIITVSLSVTVVLCGLCHWCQRKLGKRYKNSLETVGTPD
SGRGRSEKKAIKLPAGGKAVNTAPVPGQTPHDESDRRTEPRSSVSDLVNSLTSEMLMLSP
GSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFSGTSDPFVKIYLL
PDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSI
PLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGG
TSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDK
LSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQLKA
GenBank ID Protein 38570146
UniProtKB/Swiss-Prot ID O43581
UniProtKB/Swiss-Prot Entry Name SYT7_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004200.2
GeneCard ID SYT7
GenAtlas ID SYT7
HGNC ID HGNC:11514
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  3. Cooper PR, Nowak NJ, Higgins MJ, Church DM, Shows TB: Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes. Genomics. 1998 May 1;49(3):419-29. [PubMed:9615227 ]