Hmdb loader
Survey

Showing Protein Transient receptor potential cation channel subfamily M member 4 (HMDBP08082)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP08082
Secondary Accession Numbers
  • 13793
Name Transient receptor potential cation channel subfamily M member 4
Synonyms
  1. Calcium-activated non-selective cation channel 1
  2. LTrpC-4
  3. LTrpC4
  4. Long transient receptor potential channel 4
  5. Melastatin-4
  6. hTRPM4
Gene Name TRPM4
Protein Type Unknown
Biological Properties
General Function Involved in ion channel activity
Specific Function Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:1
Locus 19q13.33
SNPs TRPM4
Gene Sequence 
>3645 bp
ATGGTGGTGCCGGAGAAGGAGCAGAGCTGGATCCCCAAGATCTTCAAGAAGAAGACCTGC
ACGACGTTCATAGTTGACTCCACAGATCCGGGAGGGACCTTGTGCCAGTGTGGGCGCCCC
CGGACCGCCCACCCCGCAGTGGCCATGGAGGATGCCTTCGGGGCAGCCGTGGTGACCGTG
TGGGACAGCGATGCACACACCACGGAGAAGCCCACCGATGCCTACGGAGAGCTGGACTTC
ACGGGGGCCGGCCGCAAGCACAGCAATTTCCTCCGGCTCTCTGACCGAACGGATCCAGCT
GCAGTTTATAGTCTGGTCACACGCACATGGGGCTTCCGTGCCCCGAACCTGGTGGTGTCA
GTGCTGGGGGGATCGGGGGGCCCCGTCCTCCAGACCTGGCTGCAGGACCTGCTGCGTCGT
GGGCTGGTGCGGGCTGCCCAGAGCACAGGAGCCTGGATTGTCACTGGGGGTCTGCACACG
GGCATCGGCCGGCATGTTGGTGTGGCTGTACGGGACCATCAGATGGCCAGCACTGGGGGC
ACCAAGGTGGTGGCCATGGGTGTGGCCCCCTGGGGTGTGGTCCGGAATAGAGACACCCTC
ATCAACCCCAAGGGCTCGTTCCCTGCGAGGTACCGGTGGCGCGGTGACCCGGAGGACGGG
GTCCAGTTTCCCCTGGACTACAACTACTCGGCCTTCTTCCTGGTGGACGACGGCACACAC
GGCTGCCTGGGGGGCGAGAACCGCTTCCGCTTGCGCCTGGAGTCCTACATCTCACAGCAG
AAGACGGGCGTGGGAGGGACTGGAATTGACATCCCTGTCCTGCTCCTCCTGATTGATGGT
GATGAGAAGATGTTGACGCGAATAGAGAACGCCACCCAGGCTCAGCTCCCATGTCTCCTC
GTGGCTGGCTCAGGGGGAGCTGCGGACTGCCTGGCGGAGACCCTGGAAGACACTCTGGCC
CCAGGGAGTGGGGGAGCCAGGCAAGGCGAAGCCCGAGATCGAATCAGGCGTTTCTTTCCC
AAAGGGGACCTTGAGGTCCTGCAGGCCCAGGTGGAGAGGATTATGACCCGGAAGGAGCTC
CTGACAGTCTATTCTTCTGAGGATGGGTCTGAGGAATTCGAGACCATAGTTTTGAAGGCC
CTTGTGAAGGCCTGTGGGAGCTCGGAGGCCTCAGCCTACCTGGATGAGCTGCGTTTGGCT
GTGGCTTGGAACCGCGTGGACATTGCCCAGAGTGAACTCTTTCGGGGGGACATCCAATGG
CGGTCCTTCCATCTCGAAGCTTCCCTCATGGACGCCCTGCTGAATGACCGGCCTGAGTTC
GTGCGCTTGCTCATTTCCCACGGCCTCAGCCTGGGCCACTTCCTGACCCCGATGCGCCTG
GCCCAACTCTACAGCGCGGCGCCCTCCAACTCGCTCATCCGCAACCTTTTGGACCAGGCG
TCCCACAGCGCAGGCACCAAAGCCCCAGCCCTAAAAGGGGGAGCTGCGGAGCTCCGGCCC
CCTGACGTGGGGCATGTGCTGAGGATGCTGCTGGGGAAGATGTGCGCGCCGAGGTACCCC
TCCGGGGGCGCCTGGGACCCTCACCCAGGCCAGGGCTTCGGGGAGAGCATGTATCTGCTC
TCGGACAAGGCCACCTCGCCGCTCTCGCTGGATGCTGGCCTCGGGCAGGCCCCCTGGAGC
GACCTGCTTCTTTGGGCACTGTTGCTGAACAGGGCACAGATGGCCATGTACTTCTGGGAG
ATGGGTTCCAATGCAGTTTCCTCAGCTCTTGGGGCCTGTTTGCTGCTCCGGGTGATGGCA
CGCCTGGAGCCTGACGCTGAGGAGGCAGCACGGAGGAAAGACCTGGCGTTCAAGTTTGAG
GGGATGGGCGTTGACCTCTTTGGCGAGTGCTATCGCAGCAGTGAGGTGAGGGCTGCCCGC
CTCCTCCTCCGTCGCTGCCCGCTCTGGGGGGATGCCACTTGCCTCCAGCTGGCCATGCAA
GCTGACGCCCGTGCCTTCTTTGCCCAGGATGGGGTACAGTCTCTGCTGACACAGAAGTGG
TGGGGAGATATGGCCAGCACTACACCCATCTGGGCCCTGGTTCTCGCCTTCTTTTGCCCT
CCACTCATCTACACCCGCCTCATCACCTTCAGGAAATCAGAAGAGGAGCCCACACGGGAG
GAGCTAGAGTTTGACATGGATAGTGTCATTAATGGGGAAGGGCCTGTCGGGACGGCGGAC
CCAGCCGAGAAGACGCCGCTGGGGGTCCCGCGCCAGTCGGGCCGTCCGGGTTGCTGCGGG
GGCCGCTGCGGGGGGCGCCGGTGCCTACGCCGCTGGTTCCACTTCTGGGGCGCGCCGGTG
ACCATCTTCATGGGCAACGTGGTCAGCTACCTGCTGTTCCTGCTGCTTTTCTCGCGGGTG
CTGCTCGTGGATTTCCAGCCGGCGCCGCCCGGCTCCCTGGAGCTGCTGCTCTATTTCTGG
GCTTTCACGCTGCTGTGCGAGGAACTGCGCCAGGGCCTGAGCGGAGGCGGGGGCAGCCTC
GCCAGCGGGGGCCCCGGGCCTGGCCATGCCTCACTGAGCCAGCGCCTGCGCCTCTACCTC
GCCGACAGCTGGAACCAGTGCGACCTAGTGGCTCTCACCTGCTTCCTCCTGGGCGTGGGC
TGCCGGCTGACCCCGGGTTTGTACCACCTGGGCCGCACTGTCCTCTGCATCGACTTCATG
GTTTTCACGGTGCGGCTGCTTCACATCTTCACGGTCAACAAACAGCTGGGGCCCAAGATC
GTCATCGTGAGCAAGATGATGAAGGACGTGTTCTTCTTCCTCTTCTTCCTCGGCGTGTGG
CTGGTAGCCTATGGCGTGGCCACGGAGGGGCTCCTGAGGCCACGGGACAGTGACTTCCCA
AGTATCCTGCGCCGCGTCTTCTACCGTCCCTACCTGCAGATCTTCGGGCAGATTCCCCAG
GAGGACATGGACGTGGCCCTCATGGAGCACAGCAACTGCTCGTCGGAGCCCGGCTTCTGG
GCACACCCTCCTGGGGCCCAGGCGGGCACCTGCGTCTCCCAGTATGCCAACTGGCTGGTG
GTGCTGCTCCTCGTCATCTTCCTGCTCGTGGCCAACATCCTGCTGGTCAACTTGCTCATT
GCCATGTTCAGTTACACATTCGGCAAAGTACAGGGCAACAGCGATCTCTACTGGAAGGCG
CAGCGTTACCGCCTCATCCGGGAATTCCACTCTCGGCCCGCGCTGGCCCCGCCCTTTATC
GTCATCTCCCACTTGCGCCTCCTGCTCAGGCAATTGTGCAGGCGACCCCGGAGCCCCCAG
CCGTCCTCCCCGGCCCTCGAGCATTTCCGGGTTTACCTTTCTAAGGAAGCCGAGCGGAAG
CTGCTAACGTGGGAATCGGTGCATAAGGAGAACTTTCTGCTGGCACGCGCTAGGGACAAG
CGGGAGAGCGACTCCGAGCGTCTGAAGCGCACGTCCCAGAAGGTGGACTTGGCACTGAAA
CAGCTGGGACACATCCGCGAGTACGAACAGCGCCTGAAAGTGCTGGAGCGGGAGGTCCAG
CAGTGTAGCCGCGTCCTGGGGTGGGTGGCCGAGGCCCTGAGCCGCTCTGCCTTGCTGCCC
CCAGGTGGGCCGCCACCCCCTGACCTGCCTGGGTCCAAAGACTGA
Protein Properties
Number of Residues 1214
Molecular Weight 134299.6
Theoretical pI 8.2
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 684-704
  • 777-797
  • 869-889
  • 893-913
  • 930-950
  • 1020-1040
Protein Sequence 
>Transient receptor potential cation channel subfamily M member 4
MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTV
WDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVS
VLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG
TKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTH
GCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLL
VAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKEL
LTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQW
RSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQA
SHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL
SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA
RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ
ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE
ELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPV
TIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSL
ASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFM
VFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFP
SILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLV
VLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFI
VISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDK
RESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLP
PGGPPPPDLPGSKD
GenBank ID Protein 20269879
UniProtKB/Swiss-Prot ID Q8TD43
UniProtKB/Swiss-Prot Entry Name TRPM4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF497623
GeneCard ID TRPM4
GenAtlas ID TRPM4
HGNC ID HGNC:17993
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Xu XZ, Moebius F, Gill DL, Montell C: Regulation of melastatin, a TRP-related protein, through interaction with a cytoplasmic isoform. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10692-7. Epub 2001 Sep 4. [PubMed:11535825 ]
  4. Launay P, Fleig A, Perraud AL, Scharenberg AM, Penner R, Kinet JP: TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell. 2002 May 3;109(3):397-407. [PubMed:12015988 ]
  5. Hofmann T, Chubanov V, Gudermann T, Montell C: TRPM5 is a voltage-modulated and Ca(2+)-activated monovalent selective cation channel. Curr Biol. 2003 Jul 1;13(13):1153-8. [PubMed:12842017 ]
  6. Nilius B, Prenen J, Droogmans G, Voets T, Vennekens R, Freichel M, Wissenbach U, Flockerzi V: Voltage dependence of the Ca2+-activated cation channel TRPM4. J Biol Chem. 2003 Aug 15;278(33):30813-20. Epub 2003 Jun 10. [PubMed:12799367 ]
  7. Earley S, Waldron BJ, Brayden JE: Critical role for transient receptor potential channel TRPM4 in myogenic constriction of cerebral arteries. Circ Res. 2004 Oct 29;95(9):922-9. Epub 2004 Oct 7. [PubMed:15472118 ]
  8. Guinamard R, Chatelier A, Demion M, Potreau D, Patri S, Rahmati M, Bois P: Functional characterization of a Ca(2+)-activated non-selective cation channel in human atrial cardiomyocytes. J Physiol. 2004 Jul 1;558(Pt 1):75-83. Epub 2004 Apr 30. [PubMed:15121803 ]
  9. Nilius B, Prenen J, Janssens A, Voets T, Droogmans G: Decavanadate modulates gating of TRPM4 cation channels. J Physiol. 2004 Nov 1;560(Pt 3):753-65. Epub 2004 Aug 26. [PubMed:15331675 ]
  10. Nilius B, Prenen J, Voets T, Droogmans G: Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch. 2004 Apr;448(1):70-5. Epub 2004 Jan 31. [PubMed:14758478 ]
  11. Launay P, Cheng H, Srivatsan S, Penner R, Fleig A, Kinet JP: TRPM4 regulates calcium oscillations after T cell activation. Science. 2004 Nov 19;306(5700):1374-7. [PubMed:15550671 ]
  12. Nilius B, Prenen J, Tang J, Wang C, Owsianik G, Janssens A, Voets T, Zhu MX: Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4. J Biol Chem. 2005 Feb 25;280(8):6423-33. Epub 2004 Dec 7. [PubMed:15590641 ]
  13. Nilius B, Prenen J, Janssens A, Owsianik G, Wang C, Zhu MX, Voets T: The selectivity filter of the cation channel TRPM4. J Biol Chem. 2005 Jun 17;280(24):22899-906. Epub 2005 Apr 21. [PubMed:15845551 ]
  14. Zhang Z, Okawa H, Wang Y, Liman ER: Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitization. J Biol Chem. 2005 Nov 25;280(47):39185-92. Epub 2005 Sep 26. [PubMed:16186107 ]
  15. Cheng H, Beck A, Launay P, Gross SA, Stokes AJ, Kinet JP, Fleig A, Penner R: TRPM4 controls insulin secretion in pancreatic beta-cells. Cell Calcium. 2007 Jan;41(1):51-61. Epub 2006 Jun 27. [PubMed:16806463 ]
  16. Nilius B, Mahieu F, Prenen J, Janssens A, Owsianik G, Vennekens R, Voets T: The Ca2+-activated cation channel TRPM4 is regulated by phosphatidylinositol 4,5-biphosphate. EMBO J. 2006 Feb 8;25(3):467-78. Epub 2006 Jan 19. [PubMed:16424899 ]
  17. Fonfria E, Murdock PR, Cusdin FS, Benham CD, Kelsell RE, McNulty S: Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res. 2006;26(3):159-78. [PubMed:16777713 ]
  18. Takezawa R, Cheng H, Beck A, Ishikawa J, Launay P, Kubota H, Kinet JP, Fleig A, Yamada T, Penner R: A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity. Mol Pharmacol. 2006 Apr;69(4):1413-20. Epub 2006 Jan 11. [PubMed:16407466 ]