Human Metabolome Database: Showing Protein Transient receptor potential cation channel subfamily V member 5 (HMDBP08085)

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Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08085

Secondary Accession Numbers

13796

Name

Transient receptor potential cation channel subfamily V member 5

Synonyms

CaT2
Calcium transport protein 2
ECaC
ECaC1
Epithelial calcium channel 1
OTRPC3
Osm-9-like TRP channel 3
TrpV5

Gene Name

TRPV5

Protein Type

Unknown

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
ion transport

Cellular Location

Multi-pass membrane protein
Apical cell membrane

Gene Properties

Chromosome Location

Chromosome:7

Locus

7q35

SNPs

TRPV5

Gene Sequence

>2190 bp
ATGGGGGGTTTTCTACCTAAGGCAGAAGGGCCCGGGAGCCAACTCCAGAAACTTCTGCCC
TCCTTTCTGGTCAGAGAACAAGACTGGGACCAGCACCTGGACAAGCTTCATATGCTGCAG
CAGAAGAGGATTCTAGAGTCTCCACTGCTTCGAGCATCCAAGGAAAATGACCTGTCTGTT
CTTAGGCAACTTCTACTGGACTGCACCTGTGACGTTCGACAAAGAGGAGCCCTGGGGGAG
ACGGCGCTGCACATAGCAGCCCTCTATGACAACTTGGAGGCGGCCTTGGTGCTGATGGAG
GCTGCCCCAGAGCTGGTCTTTGAGCCCACCACATGTGAGGCTTTTGCAGGTCAGACTGCA
CTGCACATCGCTGTTGTGAACCAGAATGTGAACCTGGTGCGTGCCCTGCTCACCCGCAGG
GCCAGTGTCTCTGCCAGAGCCACAGGCACTGCCTTCCGCCGTAGTCCCCGCAACCTCATC
TACTTTGGGGAGCACCCTTTGTCCTTTGCTGCCTGTGTGAACAGCGAGGAGATCGTGCGG
CTGCTCATTGAGCATGGAGCTGACATCAGGGCCCAGGACTCCCTGGGAAACACAGTATTA
CACATCCTCATCCTCCAGCCCAACAAAACCTTTGCCTGCCAGATGTACAACCTGCTGCTG
TCCTACGATGGACATGGGGACCACCTGCAGCCCCTGGACCTTGTGCCCAATCACCAGGGT
CTCACCCCCTTCAAGCTGGCTGGAGTGGAGGGTAACACTGTGATGTTCCAGCACCTGATG
CAGAAGCGGAGGCACATCCAGTGGACGTATGGACCCCTGACCTCCATTCTCTACGACCTC
ACAGAGATCGACTCCTGGGGAGAGGAGCTGTCCTTCCTGGAGCTTGTGGTCTCCTCTGAT
AAACGAGAGGCTCGCCAAATTCTGGAACAGACCCCAGTGAAGGAGCTGGTGAGCTTCAAG
TGGAACAAGTATGGCCGGCCGTACTTCTGCATCCTGGCTGCCTTGTACCTGCTCTACATG
ATCTGCTTTACCACGTGCTGCGTCTACCGCCCCCTTAAGTTTCGTGGTGGCAACCGCACT
CATTCTCGAGACATCACCATCCTCCAGCAAAAACTACTACAGGAGGCCTATGAGACACGT
GAAGATATCATCAGGCTGGTGGGGGAGCTGGTGAGCATCGTTGGGGCTGTGATCATCCTG
CTCCTAGAGATTCCAGACATCTTCAGGGTTGGTGCCTCTCGCTATTTTGGAAAGACGATT
CTTGGGGGGCCATTCCATGTCATCATCATCACCTATGCCTCCCTGGTGCTGGTGACCATG
GTGATGCGGCTCACCAACACCAATGGGGAGGTGGTGCCCATGTCCTTTGCCCTGGTGCTG
GGCTGGTGCAGTGTCATGTATTTCACTCGAGGATTCCAGATGCTGGGTCCCTTCACCATC
ATGATCCAGAAGATGATTTTTGGAGACCTAATGCGTTTCTGCTGGCTGATGGCTGTGGTC
ATCTTGGGATTTGCCTCCGCGTTCTATATCATTTTCCAGACAGAGGACCCAACCAGTCTG
GGGCAATTCTATGACTACCCCATGGCACTGTTCACCACCTTTGAGCTTTTTCTCACTGTT
ATTGATGCACCTGCCAACTACGACGTGGACTTGCCCTTCATGTTCAGCATTGTCAACTTC
GCCTTCGCCATCATTGCCACACTGCTCATGCTCAACTTGTTCATCGCCATGATGGGCGAC
ACCCACTGGAGGGTGGCCCAGGAGAGGGATGAGCTCTGGAGGGCCCAGGTCGTGGCCACC
ACAGTGATGCTGGAGCGGAAGCTGCCTCGCTGCCTGTGGCCTCGCTCCGGGATCTGTGGG
TGCGAATTCGGGCTGGGGGACCGCTGGTTCCTGCGGGTTGAGAACCACAATGATCAGAAT
CCTCTGCGAGTGCTTCGCTATGTGGAAGTGTTCAAGAACTCAGACAAGGAGGATGACCAG
GAGCATCCATCTGAGAAACAGCCCTCTGGGGCTGAGAGTGGGACTCTAGCCAGAGCCTCT
TTGGCTCTTCCAACTTCCTCCCTGTCCCGGACCGCGTCCCAGAGCAGCAGTCACCGAGGC
TGGGAGATCCTTCGTCAAAACACCCTGGGGCACTTGAATCTTGGACTGAACCTTAGTGAG
GGGGATGGAGAGGAGGTCTACCATTTTTGA

Protein Properties

Number of Residues

729

Molecular Weight

82549.9

Theoretical pI

6.43

Pfam Domain Function

Ank (PF00023 )

Signals

None

Transmembrane Regions

329-349
388-408
420-440
449-469
493-513
557-577

Protein Sequence

>Transient receptor potential cation channel subfamily V member 5
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSV
LRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTA
LHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVR
LLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQG
LTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSD
KREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRT
HSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTI
LGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTI
MIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTV
IDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVAT
TVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQ
EHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSE
GDGEEVYHF

External Links

GenBank ID Protein

17383973

UniProtKB/Swiss-Prot ID

Q9NQA5

UniProtKB/Swiss-Prot Entry Name

TRPV5_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [PubMed:12690205 ]
Peng JB, Brown EM, Hediger MA: Structural conservation of the genes encoding CaT1, CaT2, and related cation channels. Genomics. 2001 Aug;76(1-3):99-109. [PubMed:11549322 ]
Muller D, Hoenderop JG, Meij IC, van den Heuvel LP, Knoers NV, den Hollander AI, Eggert P, Garcia-Nieto V, Claverie-Martin F, Bindels RJ: Molecular cloning, tissue distribution, and chromosomal mapping of the human epithelial Ca2+ channel (ECAC1). Genomics. 2000 Jul 1;67(1):48-53. [PubMed:10945469 ]