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Identification
HMDB Protein ID HMDBP08098
Secondary Accession Numbers
  • 13809
Name Vesicle-associated membrane protein 4
Synonyms
  1. VAMP-4
Gene Name VAMP4
Protein Type Unknown
Biological Properties
General Function Involved in vesicle-mediated transport
Specific Function Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
establishment of localization
transport
vesicle-mediated transport
Cellular Location
  1. Golgi apparatus
  2. trans-Golgi network membrane
  3. Single-pass type IV membrane protein (Probable)
Gene Properties
Chromosome Location Chromosome:1
Locus 1q24-q25
SNPs VAMP4
Gene Sequence
>426 bp
ATGCCTCCCAAGTTTAAGCGCCACCTCAATGATGATGATGTCACAGGTTCTGTGAAAAGT
GAAAGGAGAAATCTTTTGGAAGATGATTCAGATGAAGAAGAGGACTTTTTTCTAAGGGGA
CCATCTGGACCAAGATTTGGACCTAGAAATGATAAAATTAAGCATGTTCAGAATCAAGTG
GATGAAGTTATTGATGTCATGCCAGAAAATATTACAAAGGTAATTGAGAGAGGGGAGAGA
CTAGATGAACTACAGGACAAATCAGAAAGCTTATCGGATAATGCAACAGCTTTTAGCAAC
AGATCCAAACAACTTCGAAGGCAAATGTGGTGGCGTGGATGCAAAATAAAAGCCATCATG
GCTTTGGTTGCTGCTATCCTTTTGCTAGTGATTATCATTCTTATAGTCATGAAATACCGT
ACTTGA
Protein Properties
Number of Residues 141
Molecular Weight 16396.7
Theoretical pI 7.52
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 116-136
Protein Sequence
>Vesicle-associated membrane protein 4
MPPKFKRHLNDDDVTGSVKSERRNLLEDDSDEEEDFFLRGPSGPRFGPRNDKIKHVQNQV
DEVIDVMQENITKVIERGERLDELQDKSESLSDNATAFSNRSKQLRRQMWWRGCKIKAIM
ALVAAILLLVIIILIVMKYRT
GenBank ID Protein 3248920
UniProtKB/Swiss-Prot ID O75379
UniProtKB/Swiss-Prot Entry Name VAMP4_HUMAN
PDB IDs Not Available
GenBank Gene ID AF044310
GeneCard ID VAMP4
GenAtlas ID VAMP4
HGNC ID HGNC:12645
References
General References
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