Human Metabolome Database: Showing Protein Potassium voltage-gated channel subfamily H member 8 (HMDBP08147)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 metabolite

Identification

HMDB Protein ID

HMDBP08147

Secondary Accession Numbers

13858

Name

Potassium voltage-gated channel subfamily H member 8

Synonyms

ELK channel 3
ELK1
ELK3
Ether-a-go-go-like potassium channel 3
Voltage-gated potassium channel subunit Kv12.1
hElk1

Gene Name

KCNH8

Protein Type

Unknown

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, outward rectifying current. Channel properties may be modulated by cAMP and subunit assembly

Pathways

Not Available

Reactions

Not Available

GO Classification

Component
membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
kinase activity
protein histidine kinase activity
two-component sensor activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
molecular transducer activity
signal transducer activity
protein kinase activity
transporter activity
ion channel activity
cation channel activity
potassium channel activity
voltage-gated potassium channel activity
Process
signaling process
signal transmission
two-component signal transduction system (phosphorelay)
establishment of localization
transport
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
regulation of gene expression
regulation of transcription
regulation of transcription, dna-dependent
regulation of cellular process
signal transduction
transmembrane transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport

Cellular Location

Membrane
Multi-pass membrane protein

Gene Properties

Chromosome Location

Chromosome:3

Locus

3p24.3

SNPs

KCNH8

Gene Sequence

>3324 bp
ATGCCGGTTATGAAAGGATTACTGGCGCCGCAAAACACCTTCCTGGACACCATCGCCACC
CGTTTTGACGGAACACATAGCAACTTCATCCTTGCCAATGCCCAGGTGGCTAAGGGTTTC
CCCATAGTCTACTGTTCCGATGGCTTCTGCGAGCTTGCTGGATTTGCCCGAACTGAAGTC
ATGCAGAAGAGTTGTAGCTGCAAGTTCTTATTTGGGGTTGAAACCAATGAGCAACTGATG
CTTCAAATAGAAAAGTCACTGGAGGAGAAAACAGAATTCAAAGGAGAAATTATGTTCTAC
AAGAAAAACGGGTCTCCATTTTGGTGCCTACTGGATATTGTTCCCATAAAGAATGAAAAA
GGAGATGTAGTACTTTTTCTGGCCTCGTTCAAAGATATAACAGATACAAAAGTGAAGATT
ACTCCAGAAGATAAAAAAGAAGACAAAGTCAAAGGAAGATCAAGAGCAGGGACCCACTTT
GACTCAGCCCGGAGACGGAGTCGAGCAGTCCTTTATCACATCTCTGGGCACCTGCAAAGA
AGAGAAAAGAACAAATTGAAAATAAATAACAATGTTTTTGTAGATAAACCAGCATTTCCG
GAGTATAAAGTTTCTGATGCAAAAAAGTCCAAATTCATACTTCTGCATTTTAGCACTTTT
AAAGCTGGCTGGGACTGGCTTATTTTGTTGGCAACGTTTTATGTTGCTGTGACTGTACCT
TACAACGTTTGCTTTATTGGCAATGACGACCTGTCCACAACTCGGAGCACAACCGTCAGT
GACATTGCAGTGGAGATTCTTTTTATTATAGATATTATTTTAAATTTCCGAACAACTTAT
GTCAGCAAGTCTGGCCAAGTTATCTTTGAAGCAAGATCAATTTGCATCCACTATGTCACA
ACCTGGTTCATCATTGATTTAATCGCTGCCCTGCCTTTTGATCTTCTGTATGCTTTCAAC
GTCACAGTGGTGTCTCTCGTGCATCTTCTAAAGACAGTGCGCCTCTTGCGTCTTTTGCGT
CTGCTGCAGAAGTTAGACCGCTATTCCCAACACAGTACTATCGTCCTGACTCTGCTCATG
TCCATGTTTGCACTCCTTGCACACTGGATGGCGTGTATCTGGTACGTCATTGGAAAAATG
GAGAGGGAAGACAACAGCCTTCTGAAGTGGGAAGTTGGTTGGCTTCATGAGTTGGGAAAG
AGACTGGAATCTCCATACTATGGCAACAATACCTTGGGGGGCCCGTCGATCCGAAGTGCC
TATATTGCCGCTCTGTACTTCACGCTGAGCAGCCTCACCAGCGTGGGTTTTGGGAACGTC
TCTGCTAATACAGATGCAGAAAAGATCTTCTCCATCTGCACCATGCTGATTGGTGCCTTG
ATGCACGCCTTGGTGTTTGGAAACGTGACAGCAATCATACAGAGGATGTACTCCAGATGG
TCCCTCTATCACACTAGAACTAAGGATCTGAAAGATTTCATCCGTGTCCATCACTTGCCC
CAACAACTCAAGCAGAGGATGCTCGAATATTTTCAAACAACCTGGTCAGTCAACAATGGA
ATAGATTCAAATGAGCTTTTGAAAGACTTTCCAGATGAACTGCGTTCTGACATCACTATG
CACTTGAACAAGGAGATCTTACAGTTGTCCCTTTTTGAATGTGCCAGCCGGGGCTGCCTC
AGGTCTCTGTCTCTACACATCAAAACCTCTTTCTGTGCTCCGGGGGAGTATCTGCTGCGT
CAAGGGGATGCTTTGCAGGCCATCTACTTTGTATGCTCGGGCTCCATGGAAGTTCTTAAA
GACAGCATGGTGCTGGCTATTCTTGGGAAAGGGGATTTAATTGGAGCAAATCTATCAATT
AAGGACCAAGTGATCAAGACCAATGCAGATGTAAAGGCTTTAACCTACTGTGATCTCCAG
TGTATCATCCTCAAAGGACTCTTTGAAGTGCTAGACCTTTACCCAGAATATGCTCACAAA
TTCGTGGAAGACATTCAGCATGACCTCACATACAACCTCCGAGAAGGTCATGAGAGTGAT
GTGATATCAAGACTATCAAACAAATCTATGGTCTCACAGTCAGAGCCCAAGGGAAATGGC
AACATCAACAAGCGACTCCCATCCATTGTGGAAGATGAGGAAGAGGAGGAGGAGGGGGAG
GAAGAGGAGGCAGTCTCCCTCTCTCCCATCTGCACAAGGGGATCTTCTTCGCGCAACAAG
AAGGTTGGAAGCAATAAAGCCTACCTGGGCTTAAGCTTAAAGCAACTGGCCTCGGGAACG
GTGCCCTTTCACTCGCCTATCAGAGTCTCCAGGTCAAATTCCCCCAAAACCAAGCAGGAA
ATTGACCCCCCCAACCATAATAAAAGGAAAGAGAAGAACTTGAAATTGCAACTTTCAACT
TTGAATAATGCTGGACCCCCAGACCTCAGTCCAAGGATTGTTGATGGAATTGAAGATGGA
AACAGCAGTGAAGAAAGTCAGACTTTTGATTTTGGCTCTGAACGAATCAGATCAGAGCCC
AGAATTTCTCCTCCTCTTGGAGATCCAGAGATTGGAGCTGCTGTTCTCTTCATCAAAGCA
GAGGAGACCAAGCAGCAGATAAACAAACTCAACAGTGAGGTAACAACATTGACTCAGGAA
GTTTCTCAGTTGGGTAAAGACATGAGAAATGTGATCCAGCTTCTGGAAAACGTTCTGTCA
CCTCAGCAGCCATCACGGTTTTGCTCTTTGCACAGCACCTCTGTGTGTCCCTCCAGGGAG
AGCTTACAGACCAGAACGAGCTGGAGTGCACACCAGCCTTGCCTACACTTGCAAACAGGC
GGGGCTGCTTATACCCAAGCACAACTTTGTAGCAGTAATATCACCTCAGACATTTGGAGT
GTGGATCCCTCCTCTGTGGGGAGCAGCCCCCAACGAACTGGAGCTCATGAGCAAAATCCT
GCAGACAGTGAACTTTATCATTCTCCAAGCCTTGATTATTCACCTTCCCACTACCAGGTT
GTCCAAGAAGGTCATTTGCAATTTTTAAGGTGCATCTCTCCACATTCAGATTCTACGTTG
ACGCCTCTGCAGTCCATTTCAGCAACTCTCTCATCTTCTGTCTGCTCCTCTTCGGAAACA
TCTTTGCACCTAGTTCTCCCAAGCAGATCAGAGGAGGGCAGCTTCAGTCAGGGAACTGTG
AGTTCCTTCAGTCTGGAAAACTTACCAGGATCTTGGAACCAGGAAGGAATGGCATCAGCT
TCTACAAAACCTTTGGAGAACCTTCCACTGGAAGTTGTCACAAGCACAGCAGAAGTGAAA
GATAACAAAGCCATAAATGTATGA

Protein Properties

Number of Residues

1107

Molecular Weight

123803.1

Theoretical pI

6.91

Pfam Domain Function

cNMP_binding (PF00027 )
Ion_trans (PF00520 )
PAS_3 (PF08447 )

Signals

None

Transmembrane Regions

226-246
256-276
299-319
328-348
358-378
449-469

Protein Sequence

>Potassium voltage-gated channel subfamily H member 8
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV
MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK
GDVVLFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQR
REKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVP
YNVCFIGNDDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVT
TWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLM
SMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSA
YIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRW
SLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITM
HLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLK
DSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHK
FVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGE
EEEAVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLASGTVPFHSPIRVSRSNSPKTKQE
IDPPNHNKRKEKNLKLQLSTLNNAGPPDLSPRIVDGIEDGNSSEESQTFDFGSERIRSEP
RISPPLGDPEIGAAVLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLS
PQQPSRFCSLHSTSVCPSRESLQTRTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWS
VDPSSVGSSPQRTGAHEQNPADSELYHSPSLDYSPSHYQVVQEGHLQFLRCISPHSDSTL
TPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSFSQGTVSSFSLENLPGSWNQEGMASA
STKPLENLPLEVVTSTAEVKDNKAINV

External Links

GenBank ID Protein

27886667

UniProtKB/Swiss-Prot ID

Q96L42

UniProtKB/Swiss-Prot Entry Name

KCNH8_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Muzny DM, Scherer SE, Kaul R, Wang J, Yu J, Sudbrak R, Buhay CJ, Chen R, Cree A, Ding Y, Dugan-Rocha S, Gill R, Gunaratne P, Harris RA, Hawes AC, Hernandez J, Hodgson AV, Hume J, Jackson A, Khan ZM, Kovar-Smith C, Lewis LR, Lozado RJ, Metzker ML, Milosavljevic A, Miner GR, Morgan MB, Nazareth LV, Scott G, Sodergren E, Song XZ, Steffen D, Wei S, Wheeler DA, Wright MW, Worley KC, Yuan Y, Zhang Z, Adams CQ, Ansari-Lari MA, Ayele M, Brown MJ, Chen G, Chen Z, Clendenning J, Clerc-Blankenburg KP, Chen R, Chen Z, Davis C, Delgado O, Dinh HH, Dong W, Draper H, Ernst S, Fu G, Gonzalez-Garay ML, Garcia DK, Gillett W, Gu J, Hao B, Haugen E, Havlak P, He X, Hennig S, Hu S, Huang W, Jackson LR, Jacob LS, Kelly SH, Kube M, Levy R, Li Z, Liu B, Liu J, Liu W, Lu J, Maheshwari M, Nguyen BV, Okwuonu GO, Palmeiri A, Pasternak S, Perez LM, Phelps KA, Plopper FJ, Qiang B, Raymond C, Rodriguez R, Saenphimmachak C, Santibanez J, Shen H, Shen Y, Subramanian S, Tabor PE, Verduzco D, Waldron L, Wang J, Wang J, Wang Q, Williams GA, Wong GK, Yao Z, Zhang J, Zhang X, Zhao G, Zhou J, Zhou Y, Nelson D, Lehrach H, Reinhardt R, Naylor SL, Yang H, Olson M, Weinstock G, Gibbs RA: The DNA sequence, annotation and analysis of human chromosome 3. Nature. 2006 Apr 27;440(7088):1194-8. [PubMed:16641997 ]
Baxter DF, Kirk M, Garcia AF, Raimondi A, Holmqvist MH, Flint KK, Bojanic D, Distefano PS, Curtis R, Xie Y: A novel membrane potential-sensitive fluorescent dye improves cell-based assays for ion channels. J Biomol Screen. 2002 Feb;7(1):79-85. [PubMed:11897058 ]
Zou A, Lin Z, Humble M, Creech CD, Wagoner PK, Krafte D, Jegla TJ, Wickenden AD: Distribution and functional properties of human KCNH8 (Elk1) potassium channels. Am J Physiol Cell Physiol. 2003 Dec;285(6):C1356-66. Epub 2003 Jul 30. [PubMed:12890647 ]