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Identification
HMDB Protein ID HMDBP08232
Secondary Accession Numbers
  • 13944
Name Methionine aminopeptidase 1D, mitochondrial
Synonyms Not Available
Gene Name MAP1D
Protein Type Unknown
Biological Properties
General Function Involved in aminopeptidase activity
Specific Function Removes the amino-terminal methionine from nascent proteins. May play a role in colon tumorigenesis
Pathways Not Available
Reactions Not Available
GO Classification
Function
metalloexopeptidase activity
exopeptidase activity
aminopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
metabolic process
macromolecule metabolic process
cellular process
protein metabolic process
proteolysis
Cellular Location
  1. Mitochondrion
Gene Properties
Chromosome Location Chromosome:2
Locus 2q31.1
SNPs MAP1D
Gene Sequence
>1008 bp
ATGGCGGCGCCCAGTGGCGTCCACCTGCTCGTCCGCAGAGGTTCTCATAGAATTTTCTCT
TCACCACTCAATCATATCTACTTACACAAGCAGTCAAGCAGTCAACAAAGAAGAAATTTC
TTTTTTCGGAGACAAAGAGATATTTCACACAGTATAGTTTTGCCGGCTGCAGTTTCTTCA
GCTCATCCGGTTCCTAAGCACATAAAGAAGCCAGACTATGTGACGACAGGCATTGTACCA
GACTGGGGAGACAGCATAGAAGTTAAGAATGAAGATCAGATTCAAGGGCTTCATCAGGCT
TGTCAGCTGGCCCGCCACGTCCTCCTCTTGGCTGGGAAGAGTTTAAAGGTTGACATGACA
ACTGAAGAGATAGATGCTCTTGTTCATCGGGAAATCATCAGTCATAATGCCTATCCCTCA
CCTCTAGGCTATGGAGGTTTTCCAAAATCTGTTTGTACCTCTGTAAACAACGTGCTCTGT
CATGGTATTCCTGACAGTCGACCTCTTCAGGATGGAGATATTATCAACATTGATGTCACA
GTCTATTACAATGGCTACCATGGAGACACCTCTGAAACATTTTTGGTGGGCAATGTGGAC
GAATGTGGTAAAAAGTTAGTGGAGGTTGCCAGGAGGTGTAGAGATGAAGCAATTGCAGCT
TGCAGAGCAGGGGCTCCCTTCTCTGTAATTGGAAACACAATCAGCCACATAACTCATCAG
AATGGTTTTCAAGTCTGTCCACATTTTGTGGGACATGGAATAGGATCTTACTTTCATGGA
CATCCAGAAATTTGGCATCATGCAAACGACAGTGATCTACCCATGGAGGAGGGCATGGCA
TTCACTATAGAGCCAATCATCACGGAGGGATCCCCTGAATTTAAAGTCCTGGAGGATGCA
TGGACTGTGGTCTCCCTAGACAATCAAAGGTCGGCGCAGTTCGAGCACACGGTTCTGATC
ACGTCGAGGGGCGCGCAGATCCTGACCAAACTACCCCATGAGGCCTGA
Protein Properties
Number of Residues 335
Molecular Weight 37087.6
Theoretical pI 6.85
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Methionine aminopeptidase 1D, mitochondrial
MAAPSGVHLLVRRGSHRIFSSPLNHIYLHKQSSSQQRRNFFFRRQRDISHSIVLPAAVSS
AHPVPKHIKKPDYVTTGIVPDWGDSIEVKNEDQIQGLHQACQLARHVLLLAGKSLKVDMT
TEEIDALVHREIISHNAYPSPLGYGGFPKSVCTSVNNVLCHGIPDSRPLQDGDIINIDVT
VYYNGYHGDTSETFLVGNVDECGKKLVEVARRCRDEAIAACRAGAPFSVIGNTISHITHQ
NGFQVCPHFVGHGIGSYFHGHPEIWHHANDSDLPMEEGMAFTIEPIITEGSPEFKVLEDA
WTVVSLDNQRSAQFEHTVLITSRGAQILTKLPHEA
GenBank ID Protein 38893021
UniProtKB/Swiss-Prot ID Q6UB28
UniProtKB/Swiss-Prot Entry Name AMP1D_HUMAN
PDB IDs Not Available
GenBank Gene ID AY374142
GeneCard ID MAP1D
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Serero A, Giglione C, Sardini A, Martinez-Sanz J, Meinnel T: An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. J Biol Chem. 2003 Dec 26;278(52):52953-63. Epub 2003 Oct 7. [PubMed:14532271 ]
  3. Leszczyniecka M, Bhatia U, Cueto M, Nirmala NR, Towbin H, Vattay A, Wang B, Zabludoff S, Phillips PE: MAP1D, a novel methionine aminopeptidase family member is overexpressed in colon cancer. Oncogene. 2006 Jun 8;25(24):3471-8. Epub 2006 Mar 27. [PubMed:16568094 ]
  4. Hu XV, Chen X, Han KC, Mildvan AS, Liu JO: Kinetic and mutational studies of the number of interacting divalent cations required by bacterial and human methionine aminopeptidases. Biochemistry. 2007 Nov 6;46(44):12833-43. Epub 2007 Oct 11. [PubMed:17929833 ]