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Identification
HMDB Protein ID HMDBP08233
Secondary Accession Numbers
  • 13945
Name Methionine aminopeptidase 1
Synonyms
  1. MAP 1
  2. MetAP 1
  3. Peptidase M 1
Gene Name METAP1
Protein Type Unknown
Biological Properties
General Function Involved in aminopeptidase activity
Specific Function Removes the amino-terminal methionine from nascent proteins. Required for normal progression through the cell cycle
Pathways Not Available
Reactions Not Available
GO Classification
Function
metalloexopeptidase activity
exopeptidase activity
aminopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
metallopeptidase activity
Process
metabolic process
macromolecule metabolic process
cellular process
protein metabolic process
proteolysis
Cellular Location
  1. Cytoplasmic
Gene Properties
Chromosome Location Chromosome:4
Locus 4q23
SNPs METAP1
Gene Sequence
>1161 bp
ATGGCGGCCGTGGAGACGCGGGTGTGCGAGACAGACGGCTGCAGCAGTGAGGCCAAGCTC
CAGTGTCCCACTTGCATCAAGCTGGGCATCCAGGGCTCGTACTTCTGCTCGCAGGAATGT
TTTAAAGGAAGTTGGGCTACTCACAAGTTACTACATAAGAAAGCAAAAGATGAAAAGGCG
AAGCGAGAAGTGTCTTCCTGGACTGTGGAAGGTGATATTAATACTGACCCATGGGCAGGT
TATCGATATACTGGTAAACTCAGACCACATTATCCACTGATGCCAACAAGGCCAGTGCCA
AGTTATATTCAAAGACCAGATTATGCTGATCATCCCTTAGGAATGTCTGAATCTGAACAG
GCTCTTAAAGGTACTTCTCAGATTAAATTACTCTCATCTGAAGATATAGAAGGGATGCGA
CTTGTATGTAGGCTTGCTAGAGAAGTTTTGGATGTTGCTGCCGGCATGATTAAACCAGGT
GTAACTACTGAAGAAATAGATCACGCTGTACACTTAGCATGTATTGCAAGAAATTGCTAC
CCTTCTCCCCTGAATTATTATAATTTCCCAAAGTCTTGTTGTACCTCAGTGAATGAAGTC
ATTTGCCATGGAATACCAGACAGAAGGCCCTTACAAGAAGGTGACATTGTTAATGTGGAT
ATCACTCTTTATCGCAATGGTTATCATGGGGACCTGAATGAGACATTTTTTGTTGGAGAA
GTGGATGATGGAGCACGGAAACTTGTTCAGACCACATATGAGTGCCTGATGCAAGCCATT
GATGCAGTGAAGCCTGGTGTTCGGTACAGAGAATTGGGAAACATTATCCAGAAGCATGCC
CAAGCAAATGGGTTTTCAGTTGTTCGAAGCTATTGTGGGCATGGAATCCACAAGCTTTTT
CATACAGCTCCCAATGTACCCCACTATGCTAAAAATAAAGCAGTTGGAGTGATGAAGTCG
GGCCATGTATTTACAATTGAGCCAATGATTTGTGAAGGCGGATGGCAGGATGAAACCTGG
CCAGATGGTTGGACTGCGGTGACAAGAGACGGAAAGCGGTCTGCTCAGTTTGAGCACACC
CTCCTGGTCACAGACACTGGCTGTGAAATCCTAACCCGGCGACTTGACAGTGCACGGCCT
CACTTCATGTCTCAATTTTAA
Protein Properties
Number of Residues 386
Molecular Weight 43214.9
Theoretical pI 7.18
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Methionine aminopeptidase 1
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKA
KREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQ
ALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCY
PSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGE
VDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLF
HTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHT
LLVTDTGCEILTRRLDSARPHFMSQF
GenBank ID Protein 194385462
UniProtKB/Swiss-Prot ID P53582
UniProtKB/Swiss-Prot Entry Name AMPM1_HUMAN
PDB IDs Not Available
GenBank Gene ID AK304239
GeneCard ID METAP1
GenAtlas ID METAP1
HGNC ID HGNC:15789
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
  2. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  3. Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005 Jan;23(1):94-101. Epub 2004 Dec 12. [PubMed:15592455 ]
  4. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
  5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al.: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1995;2(1):37-43. [PubMed:7788527 ]
  6. Addlagatta A, Hu X, Liu JO, Matthews BW: Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. [PubMed:16274222 ]
  7. Hu X, Addlagatta A, Matthews BW, Liu JO: Identification of pyridinylpyrimidines as inhibitors of human methionine aminopeptidases. Angew Chem Int Ed Engl. 2006 Jun 2;45(23):3772-5. [PubMed:16724298 ]
  8. Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO: Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. [PubMed:17114291 ]
  9. Addlagatta A, Matthews BW: Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase. Protein Sci. 2006 Aug;15(8):1842-8. Epub 2006 Jul 5. [PubMed:16823043 ]