Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08323
Secondary Accession Numbers
  • 14035
Name Cdc42 effector protein 1
Synonyms
  1. Binder of Rho GTPases 5
  2. Serum protein MSE55
Gene Name CDC42EP1
Protein Type Unknown
Biological Properties
General Function Transcription
Specific Function Probably involved in the organization of the actin cytoskeleton. Induced membrane extensions in fibroblasts
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cytoplasm
  2. Endomembrane system
  3. Peripheral membrane protein
  4. cytoskeleton
Gene Properties
Chromosome Location Chromosome:2
Locus 22q13.1
SNPs CDC42EP1
Gene Sequence
>1176 bp
ATGCCCGGCCCCCAGGGGGGCAGAGGCGCCGCCACCATGAGCCTGGGCAAGCTCTCGCCT
GTGGGCTGGGTGTCCAGTTCACAGGGAAAGAGGCGGCTGACTGCAGACATGATCAGCCAC
CCACTCGGGGACTTCCGCCACACCATGCATGTGGGCCGTGGCGGGGATGTCTTCGGGGAC
ACGTCCTTCCTCAGCAACCACGGTGGCAGCTCCGGGAGCACCCATCGCTCACCCCGCAGC
TTCCTGGCCAAGAAGCTGCAGCTGGTGCGGAGGGTGGGGGCGCCCCCCCGGAGGATGGCA
TCTCCCCCTGCACCCTCCCCGGCTCCACCGGCCATCTCCCCCATCATCAAGAACGCCATC
TCCCTGCCCCAGCTCAACCAGGCCGCCTACGACAGCCTCGTGGTTGGCAAGCTCAGCTTC
GACAGCAGCCCCACCAGCTCCACGGACGGCCACTCCAGCTACGGCCTGGACTCTGGGTTC
TGCACCATCTCCCGCCTGCCCCGCTCGGAAAAGCCGCATGACCGAGACCGGGATGGTTCC
TTCCCCTCTGAGCCCGGGCTTCGCCGCTCTGACTCTCTCTTGTCCTTCCGCCTGGACCTC
GACCTTGGGCCCTCACTCCTCAGCGAGCTGCTAGGGGTCATGAGCCTCCCAGAAGCCCCT
GCAGCTGAGACTCCAGCCCCCGCTGCAAACCCCCCAGCCCCTACTGCAAACCCCACGGGT
CCTGCTGCAAACCCCCCAGCCACTACTGCAAACCCCCCAGCGCCTGCTGCAAACCCCTCA
GCACCTGCCGCAACCCCCACGGGTCCTGCTGCAAATCCCCCAGCCCCTGCCGCAAGCTCC
ACACCCCATGGACACTGTCCCAATGGGGTAACAGCTGGGTTGGGCCCAGTGGCTGAGGTG
AAGTCCAGCCCAGTGGGAGGGGGTCCCCGAGGACCTGCTGGCCCTGCCCTCGGCAGGCAC
TGGGGAGCAGGCTGGGATGGCGGCCACCACTACCCAGAGATGGATGCGCGGCAGGAGCGG
GTGGAGGTGCTGCCCCAAGCCCGGGCCTCCTGGGAGAGCCTGGACGAAGAGTGGAGGGCG
CCCCAGGCAGGCAGCAGGACCCCAGTGCCCAGCACAGTGCAAGCAAACACCTTTGAATTT
GCGGATGCTGAGGAGGATGATGAGGTCAAGGTGTGA
Protein Properties
Number of Residues 391
Molecular Weight 40294.4
Theoretical pI 7.17
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Cdc42 effector protein 1
MPGPQGGRGAATMSLGKLSPVGWVSSSQGKRRLTADMISHPLGDFRHTMHVGRGGDVFGD
TSFLSNHGGSSGSTHRSPRSFLAKKLQLVRRVGAPPRRMASPPAPSPAPPAISPIIKNAI
SLPQLNQAAYDSLVVGKLSFDSSPTSSTDGHSSYGLDSGFCTISRLPRSEKPHDRDRDGS
FPSEPGLRRSDSLLSFRLDLDLGPSLLSELLGVMSLPEAPAAETPAPAANPPAPTANPTG
PAANPPATTANPPAPAANPSAPAATPTGPAANPPAPAASSTPHGHCPNGVTAGLGPVAEV
KSSPVGGGPRGPAGPALGRHWGAGWDGGHHYPEMDARQERVEVLPQARASWESLDEEWRA
PQAGSRTPVPSTVQANTFEFADAEEDDEVKV
GenBank ID Protein 23238226
UniProtKB/Swiss-Prot ID Q00587
UniProtKB/Swiss-Prot Entry Name BORG5_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_152243.2
GeneCard ID CDC42EP1
GenAtlas ID CDC42EP1
HGNC ID HGNC:17014
References
General References
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  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
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  9. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  13. Joberty G, Perlungher RR, Macara IG: The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97. [PubMed:10490598 ]
  14. Bahou WF, Campbell AD, Wicha MS: cDNA cloning and molecular characterization of MSE55, a novel human serum constituent protein that displays bone marrow stromal/endothelial cell-specific expression. J Biol Chem. 1992 Jul 15;267(20):13986-92. [PubMed:1629197 ]
  15. Burbelo PD, Snow DM, Bahou W, Spiegel S: MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9083-8. [PubMed:10430899 ]