Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08392
Secondary Accession Numbers
  • 14104
Name FYVE, RhoGEF and PH domain-containing protein 3
Synonyms
  1. Zinc finger FYVE domain-containing protein 5
Gene Name FGD3
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Promotes the formation of filopodia. May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ion binding
cation binding
metal ion binding
binding
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
transition metal ion binding
zinc ion binding
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cytoplasm
  2. Cytoplasm (Probable)
  3. cytoskeleton (Probable)
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs FGD3
Gene Sequence
>2178 bp
ATGGAGTCAGGCAGGGGGTCCTCAACCCCTCCAGGACCCATTGCTGCCCTAGGGATGCCA
GACACTGGGCCTGGCAGTTCCTCCCTAGGGAAGCTTCAGGCGCTCCCTGTTGGGCCCAGA
GCCCACTGTGGGGACCCTGTCAGCCTGGCTGCAGCAGGGGACGGCTCTCCAGACATAGGC
CCCACGGGAGAGCTGAGTGGTAGCTTAAAGATCCCCAACCGGGACAGCGGGATCGACAGT
CCCTCCTCCAGTGTGGCTGGAGAGAACTTTCCCTGCGAGGAGGGCTTGGAGGCTGGCCCA
AGCCCCACTGTACTGGGGGCGCACGCAGAGATGGCCCTGGACAGCCAGGTCCCGAAGGTC
ACCCCCCAGGAGGAGGCGGACAGCGACGTGGGTGAGGAACCTGACTCTGAGAACACCCCC
CAGAAGGCTGACAAGGATGCCGGCCTGGCCCAGCACTCTGGCCCCCAGAAGCTTCTCCAC
ATTGCCCAGGAGCTCCTGCACACCGAGGAGACCTATGTGAAGCGGCTGCACCTGCTGGAC
CAGGTTTTCTGCACCAGGCTGACGGATGCGGGGATCCCTCCAGAAGTCATCATGGGCATA
TTCTCTAACATCTCCTCCATCCACCGCTTCCACGGGCAGTTCCTGCTGCCGGAGCTGAAG
ACGCGGATCACGGAGGAGTGGGACACAAACCCACGGCTCGGGGACATCCTGCAGAAGCTG
GCCCCATTCCTGAAGATGTACGGCGAGTATGTCAAGAACTTTGACCGAGCCGTAGGGCTG
GTGAGCACGTGGACCCAGCGCTCCCCACTGTTTAAAGACGTCGTCCACAGCATCCAGAAG
CAGGAGGTATGCGGGAACCTGACGCTGCAGCACCACATGCTGGAGCCCGTGCAGAGGGTC
CCCCGGTACGAGCTGCTGCTCAAGGACTATCTGAAGAGGCTCCCGCAGGACGCCCCAGAC
CGGAAGGATGCGGAGAGGTCCTTGGAGCTCATCTCCACAGCCGCCAACCACTCCAATGCT
GCCATTCGGAAAGTGGAGAAAATGCACAAGCTCTTGGAGGTGTACGAGCAGCTGGGTGGG
GAAGAAGACATTGTCAACCCGGCCAATGAACTGATCAAGGAGGGCCAAATCCAGAAACTG
TCAGCCAAGAACGGCACCCCCCAGGACCGCCACCTCTTCCTGTTCAACAGCATGATCCTT
TACTGTGTGCCCAAGCTGCGGCTCATGGGCCAGAAGTTCAGCGTCCGGGAGAAGATGGAC
ATCTCAGGCCTCCAGGTGCAGGATATCGTCAAGCCAAACACAGCACATACATTCATCATA
ACAGGAAGAAAAAGGTCCCTGGAGCTGCAGACGCGGACAGAGGAAGAGAAGAAAGAATGG
ATTCAGATCATCCAGGCCACCATCGAGAAGCACAAACAGAACAGCGAAACCTTCAAGGCT
TTTGGTGGCGCCTTCAGCCAGGATGAGGACCCCAGCCTCTCTCCAGACATGCCTATCACG
AGCACCAGCCCTGTGGAGCCTGTGGTGACCACCGAAGGCAGTTCGGGTGCAGCAGGGCTC
GAGCCCAGAAAACTATCCTCTAAGACCAGACGTGACAAGGAGAAGCAGAGCTGTAAGAGC
TGTGGTGAGACCTTCAACTCCATCACCAAGAGGAGGCATCACTGCAAGCTGTGTGGGGCG
GTCATCTGTGGGAAGTGCTCCGAGTTCAAGGCCGAGAACAGCCGGCAGAGCCGTGTCTGC
AGAGATTGTTTCCTGACACAGCCAGTGGCCCCTGAGAGCACAGAGAAGACACCCACTGCA
GACCCCCAGCCCAGCCTGCTCTGCGGCCCCCTGCGGCTGTCAGAGAGCGGTGAGACCTGG
AGCGAGGTGTGGGCCGCCATCCCCATGTCAGATCCCCAGGTGCTGCACCTGCAGGGAGGC
AGCCAGGACGGCCGGCTGCCCCGCACCATCCCTCTCCCCAGCTGCAAACTGAGTGTGCCG
GACCCTGAGGAGAGGCTGGACTCGGGGCATGTGTGGAAGCTGCAGTGGGCCAAGCAGTCC
TGGTACCTGAGCGCCTCCTCCGCAGAGCTGCAGCAGCAGTGGCTGGAAACCCTAAGCACT
GCTGCCCATGGGGACACGGCCCAGGACAGCCCGGGGGCCCTGCAGCTTCAGGTCCCTATG
GGCGCAGCTGCTCCGTGA
Protein Properties
Number of Residues 725
Molecular Weight 79400.1
Theoretical pI 6.08
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>FYVE, RhoGEF and PH domain-containing protein 3
MESGRGSSTPPGPIAALGMPDTGPGSSSLGKLQALPVGPRAHCGDPVSLAAAGDGSPDIG
PTGELSGSLKIPNRDSGIDSPSSSVAGENFPCEEGLEAGPSPTVLGAHAEMALDSQVPKV
TPQEEADSDVGEEPDSENTPQKADKDAGLAQHSGPQKLLHIAQELLHTEETYVKRLHLLD
QVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTNPRLGDILQKL
APFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQHHMLEPVQRV
PRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHKLLEVYEQLGG
EEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMGQKFSVREKMD
ISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEKHKQNSETFKA
FGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTRRDKEKQSCKS
CGETFNSITKRRHHCKLCGAVICGKCSEFKAENSRQSRVCRDCFLTQPVAPESTEKTPTA
DPQPSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQGGSQDGRLPRTIPLPSCKLSVP
DPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETLSTAAHGDTAQDSPGALQLQVPM
GAAAP
GenBank ID Protein 57209237
UniProtKB/Swiss-Prot ID Q5JSP0
UniProtKB/Swiss-Prot Entry Name FGD3_HUMAN
PDB IDs Not Available
GenBank Gene ID AL389924
GeneCard ID FGD3
GenAtlas ID FGD3
HGNC ID HGNC:16027
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [PubMed:19690332 ]
  3. Zahedi RP, Lewandrowski U, Wiesner J, Wortelkamp S, Moebius J, Schutz C, Walter U, Gambaryan S, Sickmann A: Phosphoproteome of resting human platelets. J Proteome Res. 2008 Feb;7(2):526-34. Epub 2007 Dec 19. [PubMed:18088087 ]
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