Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08528
Secondary Accession Numbers
  • 14240
Name Rab3 GTPase-activating protein catalytic subunit
Synonyms
  1. RAB3 GTPase-activating protein 130 kDa subunit
  2. Rab3-GAP
  3. Rab3-GAP p130
Gene Name RAB3GAP1
Protein Type Unknown
Biological Properties
General Function Involved in Rab GTPase activator activity
Specific Function Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters
Pathways Not Available
Reactions Not Available
GO Classification Not Available
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location Chromosome:2
Locus 2q21.3
SNPs RAB3GAP1
Gene Sequence
>2946 bp
ATGGCTGCCGACAGTGAGCCCGAATCCGAGGTATTTGAGATCACGGACTTCACCACTGCC
TCGGAATGGGAAAGGTTTATTTCCAAAGTTGAAGAAGTCTTGAATGACTGGAAACTGATT
GGAAACTCTTTGGGAAAGCCACTCGAAAAGGGTATATTTACTTCTGGCACATGGGAAGAG
AAATCAGATGAAATTTCCTTTGCTGACTTCAAGTTCTCAGTCACTCATCATTATCTTGTA
CAAGAGTCCACTGATAAAGAAGGAAAGGATGAGTTATTAGAGGATGTTGTTCCACAATCT
ATGCAAGATTTGCTGGGTATGAATAATGACTTTCCTCCAAGAGCACATTGCCTGGTAAGA
TGGTATGGGCTACGTGAGTTCGTGGTGATTGCCCCTGCTGCACACAGTGACGCTGTTCTC
AGCGAATCTAAGTGCAACCTTCTTCTGAGTTCTGTTTCTATTGCCTTGGGAAACACTGGC
TGTCAGGTGCCACTCTTTGTGCAAATTCACCACAAATGGCGAAGAATGTATGTAGGAGAA
TGTCAAGGTCCTGGTGTACGAACTGATTTCGAAATGGTTCATCTTAGAAAAGTGCCAAAT
CAGTACACTCACTTATCAGGTCTGCTGGATATCTTCAAATCAAAGATTGGATGTCCTTTA
ACTCCATTGCCTCCAGTTAGTATTGCTATTCGATTTACCTATGTACTTCAAGATTGGCAG
CAGTATTTTTGGCCTCAGCAACCTCCAGACATAGATGCCCTTGTAGGAGGAGAAGTTGGA
GGCTTGGAGTTTGGCAAGTTACCATTTGGTGCCTGCGAAGATCCTATTAGTGAACTCCAT
TTAGCTACTACATGGCCTCATCTGACCGAAGGGATCATTGTGGATAATGATGTTTATTCT
GATTTGGATCCTATTCAAGCTCCACATTGGTCTGTTAGAGTTCGAAAAGCTGAGAATCCT
CAGTGTTTGCTAGGTGATTTTGTCACTGAATTTTTTAAAATTTGCCGTCGAAAGGAGTCA
ACTGATGAGATTCTTGGACGATCTGCATTTGAGGAAGAAGGCAAAGAAACTGCTGATATA
ACTCATGCTTTGTCAAAATTGACAGAGCCGGCATCAGTTCCAATTCATAAATTATCAGTT
TCAAATATGGTACACACTGCAAAGAAGAAAATCCGAAAACACAGAGGTGTAGAGGAGTCA
CCGCTAAATAATGATGTTCTTAATACTATTCTCCTGTTCTTATTCCCTGATGCTGTTTCT
GAGAAACCATTAGATGGAACTACTTCAACAGATAATAATAATCCTCCATCAGAGAGTGAA
GACTATAATCTCTACAATCAGTTCAAGTCTGCACCATCTGACAGTTTAACATACAAACTG
GCTTTGTGTCTCTGTATGATCAATTTTTACCATGGAGGGTTGAAAGGAGTGGCACACCTC
TGGCAGGAATTTGTTCTTGAAATGCGTTTCCGATGGGAAAACAACTTTCTGATTCCAGGA
TTAGCAAGTGGACCCCCAGATCTGAGGTGTTGTTTACTGCATCAGAAACTACAGATGTTA
AATTGTTGTATTGAAAGAAAGAAGGCACGTGATGAGGGGAAAAAGACAAGTGCTTCAGAT
GTCACTAATATATATCCAGGGGATGCTGGAAAAGCAGGAGACCAGTTGGTGCCAGATAAT
CTAAAAGAAACAGATAAGGAAAAGGGAGAGGTAGGAAAATCTTGGGATTCCTGGAGTGAC
AGCGAAGAAGAATTTTTTGAATGCCTAAGTGATACTGAAGAACTTAAAGGAAATGGACAA
GAGAGTGGCAAGAAAGGAGGACCTAAGGAGATGGCAAATTTAAGGCCGGAAGGACGGCTC
TATCAGCATGGGAAACTTACACTGCTGCATAATGGAGAACCTCTCTACATTCCAGTAACC
CAGGAACCAGCACCTATGACAGAAGATCTGCTAGAAGAGCAGTCTGAAGTTTTAGCTAAA
TTAGGTACATCGGCAGAGGGGGCTCACCTTCGAGCACGCATGCAGAGTGCCTGTCTGCTC
TCAGATATGGAGTCTTTTAAGGCAGCTAATCCAGGTTGCTCCCTGGAAGATTTTGTGAGG
TGGTATTCACCCCGGGATTATATTGAAGAGGAGGTGATTGATGAAAAGGGCAATGTGGTG
CTGAAAGGAGAACTGAGTGCCCGGATGAAGATTCCAAGCAATATGTGGGTAGAAGCCTGG
GAAACAGCTAAGCCAATTCCTGCTAGAAGGCAAAGGAGACTCTTTGATGATACACGGGAA
GCAGAAAAGGTGCTGCACTATCTGGCAATCCAGAAACCTGCAGACCTTGCTCGGCACCTG
TTACCTTGTGTGATTCATGCAGCTGTACTCAAGGTAAAGGAAGAAGAAAGTCTCGAAAAC
ATTTCTTCAGTTAAGAAGATCATAAAGCAGATAATATCCCATTCCAGTAAAGTTTTGCAC
TTCCCCAATCCAGAAGACAAGAAATTGGAAGAAATCATTCACCAGATTACTAATGTGGAA
GCTCTCATTGCCAGAGCTCGGTCACTAAAAGCCAAGTTTGGAACTGAGAAATGTGAACAG
GAGGAGGAAAAGGAAGATCTTGAAAGGTTTGTGAGTTGCCTGCTGGAGCAGCCTGAAGTG
TTAGTCACCGGTGCAGGAAGAGGACATGCTGGCAGGATCATTCACAAGCTGTTTGTGAAT
GCCCAGAGGGCTGCAGCTATGACTCCACCAGAGGAGGAATTGAAGAGAATGGGCTCCCCA
GAGGAAAGAAGGCAGAACTCCGTGTCAGACTTCCCACCCCCTGCTGGCCGGGAATTCATT
TTGCGCACCACTGTGCCGCGCCCTGCTCCCTACTCCAAAGCTCTGCCTCAGCGGATGTAC
AGTGTTCTCACCAAAGAGGACTTTAGACTTGCAGGTGCCTTTTCATCAGATACTTCCTTC
TTCTGA
Protein Properties
Number of Residues 981
Molecular Weight 110522.6
Theoretical pI 5.26
Pfam Domain Function Not Available
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Rab3 GTPase-activating protein catalytic subunit
MAADSEPESEVFEITDFTTASEWERFISKVEEVLNDWKLIGNSLGKPLEKGIFTSGTWEE
KSDEISFADFKFSVTHHYLVQESTDKEGKDELLEDVVPQSMQDLLGMNNDFPPRAHCLVR
WYGLREFVVIAPAAHSDAVLSESKCNLLLSSVSIALGNTGCQVPLFVQIHHKWRRMYVGE
CQGPGVRTDFEMVHLRKVPNQYTHLSGLLDIFKSKIGCPLTPLPPVSIAIRFTYVLQDWQ
QYFWPQQPPDIDALVGGEVGGLEFGKLPFGACEDPISELHLATTWPHLTEGIIVDNDVYS
DLDPIQAPHWSVRVRKAENPQCLLGDFVTEFFKICRRKESTDEILGRSAFEEEGKETADI
THALSKLTEPASVPIHKLSVSNMVHTAKKKIRKHRGVEESPLNNDVLNTILLFLFPDAVS
EKPLDGTTSTDNNNPPSESEDYNLYNQFKSAPSDSLTYKLALCLCMINFYHGGLKGVAHL
WQEFVLEMRFRWENNFLIPGLASGPPDLRCCLLHQKLQMLNCCIERKKARDEGKKTSASD
VTNIYPGDAGKAGDQLVPDNLKETDKEKGEVGKSWDSWSDSEEEFFECLSDTEELKGNGQ
ESGKKGGPKEMANLRPEGRLYQHGKLTLLHNGEPLYIPVTQEPAPMTEDLLEEQSEVLAK
LGTSAEGAHLRARMQSACLLSDMESFKAANPGCSLEDFVRWYSPRDYIEEEVIDEKGNVV
LKGELSARMKIPSNMWVEAWETAKPIPARRQRRLFDDTREAEKVLHYLAIQKPADLARHL
LPCVIHAAVLKVKEEESLENISSVKKIIKQIISHSSKVLHFPNPEDKKLEEIIHQITNVE
ALIARARSLKAKFGTEKCEQEEEKEDLERFVSCLLEQPEVLVTGAGRGHAGRIIHKLFVN
AQRAAAMTPPEEELKRMGSPEERRQNSVSDFPPPAGREFILRTTVPRPAPYSKALPQRMY
SVLTKEDFRLAGAFSSDTSFF
GenBank ID Protein 55743118
UniProtKB/Swiss-Prot ID Q15042
UniProtKB/Swiss-Prot Entry Name RB3GP_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_012233.2
GeneCard ID RAB3GAP1
GenAtlas ID RAB3GAP1
HGNC ID HGNC:17063
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell. 2006 Nov 3;127(3):635-48. [PubMed:17081983 ]
  3. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  4. Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S: Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. DNA Res. 1994;1(5):223-9. [PubMed:7584044 ]
  5. Fukui K, Sasaki T, Imazumi K, Matsuura Y, Nakanishi H, Takai Y: Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins. J Biol Chem. 1997 Feb 21;272(8):4655-8. [PubMed:9030515 ]
  6. Oishi H, Sasaki T, Nagano F, Ikeda W, Ohya T, Wada M, Ide N, Nakanishi H, Takai Y: Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis. J Biol Chem. 1998 Dec 18;273(51):34580-5. [PubMed:9852129 ]
  7. Clabecq A, Henry JP, Darchen F: Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP. J Biol Chem. 2000 Oct 13;275(41):31786-91. [PubMed:10859313 ]
  8. Aligianis IA, Johnson CA, Gissen P, Chen D, Hampshire D, Hoffmann K, Maina EN, Morgan NV, Tee L, Morton J, Ainsworth JR, Horn D, Rosser E, Cole TR, Stolte-Dijkstra I, Fieggen K, Clayton-Smith J, Megarbane A, Shield JP, Newbury-Ecob R, Dobyns WB, Graham JM Jr, Kjaer KW, Warburg M, Bond J, Trembath RC, Harris LW, Takai Y, Mundlos S, Tannahill D, Woods CG, Maher ER: Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. Nat Genet. 2005 Mar;37(3):221-3. [PubMed:15696165 ]