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| Identification |
|---|
| HMDB Protein ID
| HMDBP08559 |
| Secondary Accession Numbers
| |
| Name
| GTP-binding protein Rit1 |
| Synonyms
|
- Ras-like protein expressed in many tissues
- Ras-like without CAAX protein 1
|
| Gene Name
| RIT1 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in GTP binding |
| Specific Function
| Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF- dependent neuronal differentiation |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Component |
| membrane |
| cell part |
| intracellular |
| Function |
| purine nucleotide binding |
| binding |
| nucleotide binding |
| catalytic activity |
| hydrolase activity |
| guanyl nucleotide binding |
| guanyl ribonucleotide binding |
| gtp binding |
| gtpase activity |
| nucleoside-triphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
| intracellular signal transduction |
| small gtpase mediated signal transduction |
|
| Cellular Location
|
- Cell membrane
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q22 |
| SNPs
| RIT1 |
| Gene Sequence
|
>660 bp
ATGGATTCTGGAACTCGCCCAGTTGGTAGCTGCTGTAGCAGCCCCGCTGGGCTCTCACGG
GAGTACAAACTAGTGATGCTGGGTGCTGGTGGTGTAGGGAAGAGTGCCATGACCATGCAG
TTCATCAGCCACCGATTCCCAGAAGATCATGATCCCACCATTGAAGATGCTTATAAGATC
AGGATCCGTATTGATGATGAGCCTGCCAATCTGGACATTTTGGATACAGCTGGACAGGCA
GAGTTTACAGCCATGCGGGACCAGTATATGAGGGCAGGAGAAGGGTTTATCATCTGTTAC
TCTATCACGGATCGTCGAAGTTTCCATGAAGTTCGAGAGTTTAAACAGCTTATTTATCGA
GTCCGACGTACTGACGATACACCTGTGGTTCTTGTGGGAAACAAGTCAGACCTCAAACAG
CTAAGACAGGTCACCAAGGAAGAAGGATTGGCCTTGGCCCGAGAATTCAGCTGTCCCTTT
TTTGAGACATCTGCTGCATACCGCTACTATATTGATGATGTTTTCCATGCCCTTGTACGG
GAGATACGTAGGAAAGAAAAGGAGGCAGTACTGGCCATGGAGAAAAAATCTAAGCCCAAA
AACAGTGTATGGAAGAGGCTAAAATCACCATTCCGGAAGAAGAAAGATTCAGTAACTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 219 |
| Molecular Weight
| 25144.6 |
| Theoretical pI
| 9.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>GTP-binding protein Rit1
MDSGTRPVGSCCSSPAGLSREYKLVMLGAGGVGKSAMTMQFISHRFPEDHDPTIEDAYKI
RIRIDDEPANLDILDTAGQAEFTAMRDQYMRAGEGFIICYSITDRRSFHEVREFKQLIYR
VRRTDDTPVVLVGNKSDLKQLRQVTKEEGLALAREFSCPFFETSAAYRYYIDDVFHALVR
EIRRKEKEAVLAMEKKSKPKNSVWKRLKSPFRKKKDSVT
|
| External Links |
|---|
| GenBank ID Protein
| 4234918 |
| UniProtKB/Swiss-Prot ID
| Q92963 |
| UniProtKB/Swiss-Prot Entry Name
| RIT1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF084462 |
| GeneCard ID
| RIT1 |
| GenAtlas ID
| RIT1 |
| HGNC ID
| HGNC:10023 |
| References |
|---|
| General References
| - Lee CH, Della NG, Chew CE, Zack DJ: Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J Neurosci. 1996 Nov 1;16(21):6784-94. [PubMed:8824319 ]
- Wes PD, Yu M, Montell C: RIC, a calmodulin-binding Ras-like GTPase. EMBO J. 1996 Nov 1;15(21):5839-48. [PubMed:8918462 ]
- Shao H, Kadono-Okuda K, Finlin BS, Andres DA: Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch Biochem Biophys. 1999 Nov 15;371(2):207-19. [PubMed:10545207 ]
- Shi GX, Andres DA: Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades. Mol Cell Biol. 2005 Jan;25(2):830-46. [PubMed:15632082 ]
|
