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Identification
HMDB Protein ID HMDBP08578
Secondary Accession Numbers
  • 14293
Name SH3 domain-containing guanine exchange factor
Synonyms Not Available
Gene Name SGEF
Protein Type Unknown
Biological Properties
General Function Involved in Rho guanyl-nucleotide exchange factor activity
Specific Function Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry
Pathways Not Available
Reactions Not Available
GO Classification
Component
cell part
intracellular
Function
small gtpase regulator activity
ras guanyl-nucleotide exchange factor activity
rho guanyl-nucleotide exchange factor activity
enzyme regulator activity
nucleoside-triphosphatase regulator activity
gtpase regulator activity
Process
regulation of ras protein signal transduction
regulation of rho protein signal transduction
biological regulation
regulation of biological process
regulation of cellular process
regulation of cell communication
regulation of signal transduction
regulation of small gtpase mediated signal transduction
Cellular Location
  1. Cell projection
  2. ruffle
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs SGEF
Gene Sequence
>2616 bp
ATGGACGGCGAGAGCGAGGTGGATTTTTCTAGCAACAGCATAACCCCTTTGTGGCGGAGG
CGGTCGATTCCTCAGCCCCACCAGGTTCTGGGCCGGAGCAAGCCGAGGCCCCAGTCCTAC
CAGAGCCCCAACGGGTTACTAATTACGGATTTCCCGGTGGAGGACGGAGGGACGCTCCTC
GCAGCGCAGATTCCCGCCCAGGTGCCCACCGCCTCGGACAGCAGGACGGTACATAGGAGC
CCCCTGCTTCTGGGCGCCCAGCGGAGAGCGGTGGCCAATGGTGGGACGGCATCCCCGGAG
TACAGGGCTGCCTCTCCTCGACTTCGACGGCCCAAGTCACCCAAGCTCCCCAAAGCGGTG
CCTGGCGGCTCCCCGAAATCCCCAGCAAATGGCGCGGTGACCTTGCCTGCGCCGCCGCCG
CCGCCGGTTCTGCGCCCCCCGCGGACTCCTAACGCGCCCGCCCCCTGCACCCCCGAGGAG
GACCTTACTGGGTTGACTGCCAGCCCGGTGCCTTCGCCCACTGCAAATGGCCTTGCCGCT
AATAACGACTCTCCTGGGTCAGGTTCGCAGTCCGGCCGGAAGGCAAAGGACCCCGAACGG
GGGCTCTTTCCTGGGCCCCAGAAAAGTTCTTCGGAACAAAAACTCCCCCTCCAAAGGCTG
CCCTCCCAGGAGAACGAGCTCCTCGAGAATCCTTCCGTGGTTTTGAGTACAAACAGCCCC
GCCGCCCTCAAAGTGGGGAAGCAGCAGATCATTCCGAAGAGTCTGGCCTCGGAAATTAAA
ATAAGTAAATCCAACAATCAAAATGTGGAGCCCCACAAGAGACTCCTCAAGGTGCGCAGC
ATGGTGGAGGGCCTAGGAGGACCCCTGGGTCACGCAGGGGAGGAGAGTGAGGTCGATAAC
GACGTGGATAGCCCAGGGTCTCTGCGGAGAGGCTTGCGGTCCACGTCTTATCGCAGGGCA
GTGGTCAGTGGCTTTGATTTTGACAGTCCTACCAGCTCGAAGAAGAAGAACAGAATGTCC
CAGCCTGTTCTGAAAGTGGTGATGGAAGACAAGGAGAAGTTTTCCAGTCTGGGAAGGATA
AAGAAAAAAATGCTGAAAGGACAAGGAACATTTGATGGGGAAGAAAATGCTGTCCTGTAT
CAAAACTACAAGGAAAAGGCCCTTGACATTGATTCTGATGAAGAGTCAGAGCCCAAAGAA
CAGAAGTCAGATGAAAAAATTGTGATTCACCATAAGCCATTGAGATCCACATGGAGCCAA
CTCTCTGCGGTGAAAAGAAAGGGATTATCTCAGACAGTAAGCCAGGAGGAAAGAAAGAGA
CAAGAGGCTATCTTTGAAGTCATATCCTCTGAACATTCATATTTACTCAGCTTGGAGATC
TTGATACGAATGTTTAAAAATTCTAAAGAACTGAGTGATACAATGACTAAAACCGAGAGG
CACCATCTTTTCTCCAATATTACAGATGTCTGTGAGGCAAGCAAAAAGTTCTTTATAGAG
TTGGAAGCAAGACATCAGAATAATATCTTCATAGATGACATAAGTGACATTGTGGAAAAA
CACACAGCATCCACATTTGACCCATATGTGAAATACTGCACAAATGAAGTCTACCAACAA
CGAACACTACAAAAATTGTTAGCTACCAATCCATCCTTTAAGGAAGTATTGTCAAGGATT
GAGTCCCATGAAGACTGTAGGAACTTACCCATGATCTCTTTTCTCATTCTCCCCATGCAG
AGGGTGACCCGCCTTCCCCTGCTGATGGATACTATCTGTCAAAAAACACCTAAGGACTCT
CCGAAGTATGAAGTCTGCAAAAGAGCCTTGAAGGAAGTTAGCAAGTTGGTTCGACTATGC
AATGAGGGCGCCCGGAAGATGGAAAGGACTGAGATGATGTACACAATTAACTCCCAGCTG
GAATTTAAAATTAAGCCTTTTCCTTTAGTCTCCTCTTCCCGGTGGTTGGTAAAAAGAGGT
GAATTGACAGCCTATGTTGAAGACACTGTGCTTTTCTCAAGAAGGACATCCAAACAGCAA
GTCTACTTCTTTCTCTTTAACGATGTGCTCATTATCACCAAGAAGAAGAGTGAAGAAAGT
TACAACGTCAATGATTATTCCTTAAGAGATCAGCTATTGGTGGAATCTTGTGACAATGAA
GAGCTTAATTCTTCTCCAGGGAAGAACAGCTCCACAATGCTCTATTCAAGACAGAGCTCT
GCCAGTCACCTCTTTACTCTGACAGTCCTTAGTAACCACGCGAATGAGAAAGTGGAGATG
CTACTAGGAGCTGAGACGCAGAGCGAGCGAGCCCGCTGGATAACTGCCCTGGGACACAGC
AGCGGGAAGCCGCCTGCAGACCGAACCTCACTGACCCAGGTGGAAATCGTTAGGTCATTT
ACTGCTAAGCAGCCAGATGAACTCTCCCTGCAGGTGGCTGACGTCGTCCTCATCTATCAA
CGTGTCAGCGATGGCTGGTATGAGGGGGAACGACTACGAGATGGAGAAAGAGGCTGGTTT
CCTATGGAATGTGCCAAGGAGATAACATGTCAAGCTACAATTGATAAGAATGTGGAGAGA
ATGGGACGCTTGCTAGGACTGGAGACCAACGTGTAG
Protein Properties
Number of Residues 871
Molecular Weight 97358.7
Theoretical pI 9.38
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>SH3 domain-containing guanine exchange factor
MDGESEVDFSSNSITPLWRRRSIPQPHQLLGRSKPRPQSYQSPNGLLITDFPVEDGGTLL
AAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAV
PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA
NNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSP
AALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDN
DVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRI
KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQ
LSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTER
HHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQ
RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS
PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG
ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNE
ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS
SGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWF
PMECAKEITCQATIDKNVERMGRLLGLETNV
GenBank ID Protein 194473700
UniProtKB/Swiss-Prot ID Q96DR7
UniProtKB/Swiss-Prot Entry Name SGEF_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_015595.3
GeneCard ID SGEF
GenAtlas ID ARHGEF26
HGNC ID HGNC:24490
References
General References
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