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Showing Protein Mitoferrin-1 (HMDBP08658)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP08658
Secondary Accession Numbers
  • 14377
Name Mitoferrin-1
Synonyms
  1. Mitochondrial iron transporter 1
  2. Mitochondrial solute carrier protein
  3. Solute carrier family 25 member 37
Gene Name SLC25A37
Protein Type Unknown
Biological Properties
General Function Involved in binding
Specific Function Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme
Pathways Not Available
Reactions Not Available
GO Classification
Component
membrane
cell part
Function
binding
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Mitochondrion inner membrane
  2. Multi-pass membrane protein
Gene Properties
Chromosome Location Chromosome:8
Locus 8p21.2
SNPs SLC25A37
Gene Sequence 
>1017 bp
ATGGAGCTGCGCAGCGGGAGCGTGGGCAGCCAGGCGGTGGCGCGGAGGATGGATGGGGAC
AGCCGAGATGGCGGCGGCGGCAAGGACGCCACCGGGTCGGAGGACTACGAGAACCTGCCG
ACTAGCGCCTCCGTGTCCACCCACATGACAGCAGGAGCGATGGCCGGGATCCTGGAGCAC
TCGGTCATGTACCCGGTGGACTCGGTGAAGACACGAATGCAGAGTTTGAGTCCAGATCCC
AAAGCCCAGTACACAAGTATCTACGGAGCCCTCAAGAAAATCATGCGGACCGAAGGCTTC
TGGAGGCCCTTGCGAGGCGTCAACGTCATGATCATGGGTGCAGGGCCGGCCCATGCCATG
TATTTTGCCTGCTATGAAAACATGAAAAGGACTTTAAATGACGTTTTCCACCACCAAGGA
AACAGCCACCTAGCCAACGGGATAGCTGGGAGTATGGCCACCCTGCTCCACGATGCGGTA
ATGAATCCAGCAGAAGTGGTGAAGCAGCGCTTGCAGATGTACAACTCGCAGCACCGGTCA
GCAATCAGCTGCATCCGGACGGTGTGGAGGACCGAGGGGTTGGGGGCCTTCTACCGGAGC
TACACCACGCAGCTGACCATGAACATCCCCTTCCAGTCCATCCACTTCATCACCTATGAG
TTCCTGCAGGAGCAGGTCAACCCCCACCGGACCTACAACCCGCAGTCCCACATCATCTCA
GGCGGGCTGGCCGGGGCCCTCGCCGCGGCCGCCACGACCCCCCTGGACGTCTGTAAGACC
CTTCTGAACACTCAGGAGAACGTGGCCCTCTCGCTGGCCAACATCAGCGGCCGGCTGTCG
GGTATGGCCAATGCCTTCCGGACGGTGTACCAGCTCAACGGCCTGGCCGGCTACTTCAAA
GGCATCCAGGCGCGTGTCATCTACCAGATGCCCTCCACCGCCATTTCTTGGTCTGTCTAT
GAGTTCTTCAAGTACTTTCTCACCAAGCGCCAGCTGGAAAATCGAGCTCCATACTAA
Protein Properties
Number of Residues 338
Molecular Weight 37322.3
Theoretical pI 9.55
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • 45-64
  • 106-125
  • 143-162
  • 200-219
  • 234-253
  • 301-320
Protein Sequence 
>Mitoferrin-1
MELRSGSVGSQAVARRMDGDSRDGGGGKDATGSEDYENLPTSASVSTHMTAGAMAGILEH
SVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVMIMGAGPAHAM
YFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRS
AISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYEFLQEQVNPHRTYNPQSHIIS
GGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFK
GIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENRAPY
GenBank ID Protein 82775373
UniProtKB/Swiss-Prot ID Q9NYZ2
UniProtKB/Swiss-Prot Entry Name MFRN1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_016612.2
GeneCard ID SLC25A37
GenAtlas ID SLC25A37
HGNC ID HGNC:29786
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9543-8. [PubMed:10931946 ]
  3. Imami K, Sugiyama N, Kyono Y, Tomita M, Ishihama Y: Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Anal Sci. 2008 Jan;24(1):161-6. [PubMed:18187866 ]
  4. Bechtel S, Rosenfelder H, Duda A, Schmidt CP, Ernst U, Wellenreuther R, Mehrle A, Schuster C, Bahr A, Blocker H, Heubner D, Hoerlein A, Michel G, Wedler H, Kohrer K, Ottenwalder B, Poustka A, Wiemann S, Schupp I: The full-ORF clone resource of the German cDNA Consortium. BMC Genomics. 2007 Oct 31;8:399. [PubMed:17974005 ]
  5. Li QZ, Eckenrode S, Ruan QG, Wang CY, Shi JD, McIndoe RA, She JX: Rapid decrease of RNA level of a novel mouse mitochondria solute carrier protein (Mscp) gene at 4-5 weeks of age. Mamm Genome. 2001 Nov;12(11):830-6. [PubMed:11845285 ]