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Identification
HMDB Protein ID HMDBP08662
Secondary Accession Numbers
  • 14381
Name Neuroglobin
Synonyms Not Available
Gene Name NGB
Protein Type Unknown
Biological Properties
General Function Involved in iron ion binding
Specific Function Involved in oxygen transport in the brain
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
iron ion binding
heme binding
oxygen binding
Process
establishment of localization
transport
gas transport
oxygen transport
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 14q24.3
SNPs NGB
Gene Sequence
>456 bp
ATGGAGCGCCCGGAGCCCGAGCTGATCCGGCAGAGCTGGCGGGCAGTGAGCCGCAGCCCG
CTGGAGCACGGCACCGTCCTGTTTGCCAGGCTGTTTGCCCTGGAGCCTGACCTGCTGCCC
CTCTTCCAGTACAACTGCCGCCAGTTCTCCAGCCCAGAGGACTGTCTCTCCTCGCCTGAG
TTCCTGGACCACATCAGGAAGGTGATGCTCGTGATTGATGCTGCAGTGACCAATGTGGAA
GACCTGTCCTCACTGGAGGAGTACCTTGCCAGCCTGGGCAGGAAGCACCGGGCAGTGGGT
GTGAAGCTCAGCTCCTTCTCGACAGTGGGTGAGTCTCTGCTCTACATGCTGGAGAAGTGT
CTGGGCCCTGCCTTCACACCAGCCACACGGGCTGCCTGGAGCCAACTCTACGGGGCCGTA
GTGCAGGCCATGAGTCGAGGCTGGGATGGCGAGTAA
Protein Properties
Number of Residues 151
Molecular Weight 16933.2
Theoretical pI 5.24
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Neuroglobin
MERPEPELIRQSWRAVSRSPLEHGTVLFARLFALEPDLLPLFQYNCRQFSSPEDCLSSPE
FLDHIRKVMLVIDAAVTNVEDLSSLEEYLASLGRKHRAVGVKLSSFSTVGESLLYMLEKC
LGPAFTPATRAAWSQLYGAVVQAMSRGWDGE
GenBank ID Protein 7527761
UniProtKB/Swiss-Prot ID Q9NPG2
UniProtKB/Swiss-Prot Entry Name NGB_HUMAN
PDB IDs
GenBank Gene ID AC007375
GeneCard ID NGB
GenAtlas ID NGB
HGNC ID HGNC:14077
References
General References
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  2. Heilig R, Eckenberg R, Petit JL, Fonknechten N, Da Silva C, Cattolico L, Levy M, Barbe V, de Berardinis V, Ureta-Vidal A, Pelletier E, Vico V, Anthouard V, Rowen L, Madan A, Qin S, Sun H, Du H, Pepin K, Artiguenave F, Robert C, Cruaud C, Bruls T, Jaillon O, Friedlander L, Samson G, Brottier P, Cure S, Segurens B, Aniere F, Samain S, Crespeau H, Abbasi N, Aiach N, Boscus D, Dickhoff R, Dors M, Dubois I, Friedman C, Gouyvenoux M, James R, Madan A, Mairey-Estrada B, Mangenot S, Martins N, Menard M, Oztas S, Ratcliffe A, Shaffer T, Trask B, Vacherie B, Bellemere C, Belser C, Besnard-Gonnet M, Bartol-Mavel D, Boutard M, Briez-Silla S, Combette S, Dufosse-Laurent V, Ferron C, Lechaplais C, Louesse C, Muselet D, Magdelenat G, Pateau E, Petit E, Sirvain-Trukniewicz P, Trybou A, Vega-Czarny N, Bataille E, Bluet E, Bordelais I, Dubois M, Dumont C, Guerin T, Haffray S, Hammadi R, Muanga J, Pellouin V, Robert D, Wunderle E, Gauguet G, Roy A, Sainte-Marthe L, Verdier J, Verdier-Discala C, Hillier L, Fulton L, McPherson J, Matsuda F, Wilson R, Scarpelli C, Gyapay G, Wincker P, Saurin W, Quetier F, Waterston R, Hood L, Weissenbach J: The DNA sequence and analysis of human chromosome 14. Nature. 2003 Feb 6;421(6923):601-7. Epub 2003 Jan 1. [PubMed:12508121 ]
  3. Burmester T, Weich B, Reinhardt S, Hankeln T: A vertebrate globin expressed in the brain. Nature. 2000 Sep 28;407(6803):520-3. [PubMed:11029004 ]
  4. Zhang C, Wang C, Deng M, Li L, Wang H, Fan M, Xu W, Meng F, Qian L, He F: Full-length cDNA cloning of human neuroglobin and tissue expression of rat neuroglobin. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1411-9. [PubMed:11820779 ]
  5. Dewilde S, Kiger L, Burmester T, Hankeln T, Baudin-Creuza V, Aerts T, Marden MC, Caubergs R, Moens L: Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family. J Biol Chem. 2001 Oct 19;276(42):38949-55. Epub 2001 Jul 25. [PubMed:11473128 ]
  6. Hamdane D, Kiger L, Dewilde S, Green BN, Pesce A, Uzan J, Burmester T, Hankeln T, Bolognesi M, Moens L, Marden MC: Coupling of the heme and an internal disulfide bond in human neuroglobin. Micron. 2004;35(1-2):59-62. [PubMed:15036292 ]
  7. Pesce A, Nardini M, Dewilde S, Ascenzi P, Burmester T, Hankeln T, Moens L, Bolognesi M: Human neuroglobin: crystals and preliminary X-ray diffraction analysis. Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1848-50. Epub 2002 Sep 28. [PubMed:12351835 ]
  8. Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M: Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Structure. 2003 Sep;11(9):1087-95. [PubMed:12962627 ]