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Identification
HMDB Protein ID HMDBP08722
Secondary Accession Numbers
  • 14445
Name Eyes absent homolog 3
Synonyms Not Available
Gene Name EYA3
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Pathways Not Available
Reactions
Protein tyrosine phosphate + Water → protein tyrosine + Phosphate details
GO Classification
Biological Process
multicellular organismal development
response to ionizing radiation
double-strand break repair
anatomical structure morphogenesis
histone dephosphorylation
positive regulation of DNA repair
visual perception
regulation of transcription, DNA-dependent
transcription, DNA-dependent
Cellular Component
cytoplasm
nucleus
transcription factor complex
Function
catalytic activity
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
metal ion binding
chromatin binding
protein tyrosine phosphatase activity
Process
metabolic process
multicellular organismal process
multicellular organismal development
Cellular Location
  1. Nucleus
  2. Cytoplasm
Gene Properties
Chromosome Location 1
Locus 1p36
SNPs EYA3
Gene Sequence
>1722 bp
ATGGAAGAAGAGCAAGATTTACCAGAGCAACCAGTGAAAAAAGCCAAGATGCAGGAATCA
GGAGAGCAAACTATAAGTCAAGTAAGCAATCCAGATGTCAGTGATCAGAAGCCTGAAACA
TCAAGCCTTGCTTCAAACCTTCCCATGTCAGAGGAAATTATGACATGCACCGATTACATC
CCTCGCTCATCCAATGATTATACCTCACAAATGTATTCTGCAAAACCTTATGCACATATT
CTCTCAGTTCCTGTTTCGGAAACTGCTTACCCTGGACAGACTCAATACCAGACACTACAG
CAGACTCAACCCTATGCTGTCTACCCTCAGGCAACCCAAACGTATGGACTACCTCCTTTT
GGTGCATTGTGGCCAGGTATGAAACCTGAAAGTGGTTTAATTCAGACTCCATCTCCAAGT
CAACACAGTGTTCTTACCTGCACTACAGGGTTAACCACAAGCCAGCCAAGCCCAGCACAT
TATTCTTATCCCATTCAAGCTTCAAGCACAAATGCCAGCCTGATATCTACTTCTTCTACA
ATTGCCAATATTCCAGCAGCAGCAGTAGCCAGCATCTCAAACCAGGATTATCCCACCTAT
ACTATTCTTGGTCAGAATCAGTACCAGGCCTGCTACCCCAGCTCCAGCTTTGGAGTCACA
GGTCAGACTAACAGTGATGCAGAGAGCACCACATTAGCAGCAACCACATACCAGTCGGAG
AAGCCTAGTGTCATGGCGCCTGCACCTGCAGCACAGAGACTTTCCTCTGGAGACCCTTCT
ACAAGTCCATCTTTGTCCCAGACTACACCAAGTAAAGATACTGATGATCAGTCCAGGAAA
AACATGACTAGCAAGAACCGGGGCAAGAGGAAAGCTGATGCCACTTCTTCCCAAGACAGT
GAATTAGAACGGGTATTTCTGTGGGACTTGGATGAAACCATCATCATCTTCCACTCACTT
CTTACTGGATCCTATGCCCAGAAATATGGAAAGGACCCAACAGTAGTGATTGGCTCAGGT
TTAACAATGGAAGAAATGATTTTTGAAGTGGCTGATACTCATCTATTTTTCAATGACTTA
GAGGAGTGTGACCAGGTACATGTGGAAGATGTGGCTTCTGATGACAATGGCCAAGACTTG
AGCAACTACAGTTTCTCAACAGATGGTTTCAGTGGCTCAGGAGGTAGTGGCAGCCATGGT
TCATCTGTGGGTGTTCAGGGAGGTGTGGACTGGATGAGGAAACTAGCTTTCCGCTACCGG
AAAGTGAGAGAAATCTATGATAAGCATAAAAGCAACGTGGGTGGTCTCCTCAGTCCCCAG
AGGAAGGAAGCACTGCAGAGATTAAGAGCAGAAATTGAAGTTTTAACAGATTCCTGGTTA
GGAACTGCATTAAAGTCCTTACTTCTCATCCAGTCCAGAAAGAATTGTGTGAATGTTCTG
ATCACTACCACCCAGCTGGTTCCAGCCCTGGCCAAGGTTCTCCTATATGGACTAGGAGAA
ATATTTCCTATTGAGAACATCTATAGTGCTACCAAAATTGGTAAGGAGAGCTGCTTTGAG
AGAATTGTGTCAAGGTTTGGAAAGAAAGTCACATATGTAGTGATTGGAGATGGACGAGAT
GAAGAAATTGCAGCCAAACAGCACAACATGCCTTTCTGGAGGATCACAAACCATGGAGAC
CTAGTATCCCTTCACCAGGCTTTAGAGCTTGATTTTCTCTAA
Protein Properties
Number of Residues 573
Molecular Weight 62662.3
Theoretical pI 5.213
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Eyes absent homolog 3
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYI
PRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPF
GALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSST
IANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSE
KPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDS
ELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDL
EECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYR
KVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVL
ITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRD
EEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
GenBank ID Protein 26667243
UniProtKB/Swiss-Prot ID Q99504
UniProtKB/Swiss-Prot Entry Name EYA3_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001990.2
GeneCard ID EYA3
GenAtlas ID EYA3
HGNC ID HGNC:3521
References
General References
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  3. Gauci S, Helbig AO, Slijper M, Krijgsveld J, Heck AJ, Mohammed S: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. Anal Chem. 2009 Jun 1;81(11):4493-501. doi: 10.1021/ac9004309. [PubMed:19413330 ]
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  5. Cook PJ, Ju BG, Telese F, Wang X, Glass CK, Rosenfeld MG: Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature. 2009 Apr 2;458(7238):591-6. doi: 10.1038/nature07849. Epub 2009 Feb 22. [PubMed:19234442 ]
  6. Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, Weil D, Cruaud C, Sahly I, Leibovici M, Bitner-Glindzicz M, Francis M, Lacombe D, Vigneron J, Charachon R, Boven K, Bedbeder P, Van Regemorter N, Weissenbach J, Petit C: A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet. 1997 Feb;15(2):157-64. [PubMed:9020840 ]
  7. Zimmerman JE, Bui QT, Steingrimsson E, Nagle DL, Fu W, Genin A, Spinner NB, Copeland NG, Jenkins NA, Bucan M, Bonini NM: Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res. 1997 Feb;7(2):128-41. [PubMed:9049631 ]
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