Hmdb loader
Survey
Identification
HMDB Protein ID HMDBP08786
Secondary Accession Numbers
  • 14509
Name [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
Synonyms
  1. PDP 1
  2. PDPC 1
  3. Protein phosphatase 2C
  4. Pyruvate dehydrogenase phosphatase catalytic subunit 1
Gene Name PDP1
Protein Type Unknown
Biological Properties
General Function Involved in catalytic activity
Specific Function Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (By similarity).
Pathways Not Available
Reactions
[Pyruvate dehydrogenase (acetyl-transferring)] phosphate + Water → [pyruvate dehydrogenase (acetyl-transferring)] + Phosphate details
GO Classification
Biological Process
regulation of acetyl-CoA biosynthetic process from pyruvate
pyruvate metabolic process
peptidyl-threonine dephosphorylation
Cellular Component
mitochondrial matrix
Component
macromolecular complex
protein complex
protein serine/threonine phosphatase complex
Function
phosphoprotein phosphatase activity
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
phosphoric ester hydrolase activity
phosphatase activity
protein serine/threonine phosphatase activity
Molecular Function
protein serine/threonine phosphatase activity
calcium ion binding
[pyruvate dehydrogenase (lipoamide)] phosphatase activity
magnesium-dependent protein serine/threonine phosphatase activity
Process
phosphorus metabolic process
phosphate metabolic process
dephosphorylation
protein amino acid dephosphorylation
metabolic process
cellular metabolic process
Cellular Location
  1. Mitochondrion matrix
Gene Properties
Chromosome Location 8
Locus 8q22.1
SNPs PDP1
Gene Sequence
>1614 bp
ATGCCAGCACCAACTCAACTGTTTTTTCCTCTCATCCGTAACTGTGAACTGAGCAGGATC
TATGGCACTGCATGTTACTGCCACCACAAACATCTCTGTTGTTCCTCATCGTACATTCCT
CAGAGTCGACTGAGATACACACCTCATCCAGCATATGCTACCTTTTGCAGGCCAAAGGAG
AACTGGTGGCAGTACACCCAAGGAAGGAGATATGCTTCCACACCACAGAAATTTTACCTC
ACACCTCCACAAGTCAATAGCATCCTTAAAGCTAATGAATACAGTTTCAAAGTGCCAGAA
TTTGACGGCAAAAATGTCAGTTCTATCCTTGGATTTGACAGCAATCAGCTGCCTGCAAAT
GCACCCATTGAGGACCGGAGAAGTGCAGCAACCTGCTTGCAGACCAGAGGGATGCTTTTG
GGGGTTTTTGATGGCCATGCAGGTTGTGCTTGTTCCCAGGCAGTCAGTGAAAGACTCTTT
TATTATATTGCTGTCTCTTTGTTACCCCATGAGACTTTGCTAGAGATTGAAAATGCAGTG
GAGAGCGGCCGGGCACTGCTACCCATTCTCCAGTGGCACAAGCACCCCAATGATTACTTT
AGTAAGGAGGCATCCAAATTGTACTTTAACAGCTTGAGGACTTACTGGCAAGAGCTTATA
GACCTCAACACTGGTGAGTCGACTGATATTGATGTTAAGGAGGCTCTAATTAATGCCTTC
AAGAGGCTTGATAATGACATCTCCTTGGAGGCGCAAGTTGGTGATCCTAATTCTTTTCTC
AACTACCTGGTGCTTCGAGTGGCATTTTCTGGAGCCACTGCTTGTGTGGCCCATGTGGAT
GGTGTTGACCTTCATGTGGCCAATACTGGCGATAGCAGAGCCATGCTGGGTGTGCAGGAA
GAGGACGGCTCATGGTCAGCAGTCACGCTGTCTAATGACCACAATGCTCAAAATGAAAGA
GAACTAGAACGGCTGAAATTGGAACATCCAAAGAGTGAGGCCAAGAGTGTCGTGAAACAG
GATCGGCTGCTTGGCTTGCTGATGCCATTTAGGGCATTTGGAGATGTAAAGTTCAAATGG
AGCATTGACCTTCAAAAGAGAGTGATAGAATCTGGCCCAGACCAGTTGAATGACAATGAA
TATACCAAGTTTATTCCTCCTAATTATCACACACCTCCTTATCTCACTGCTGAGCCAGAG
GTAACTTACCACCGATTAAGGCCACAGGATAAGTTTCTGGTGTTGGCTACTGATGGGTTG
TGGGAGACTATGCATAGGCAGGATGTGGTTAGGATTGTGGGTGAGTACCTAACTGGCATG
CATCACCAACAGCCAATAGCTGTTGGTGGCTACAAGGTGACTCTGGGACAGATGCATGGC
CTTTTAACAGAAAGGAGAACCAAAATGTCCTCGGTATTTGAGGATCAGAACGCAGCAACC
CATCTCATTCGCCACGCTGTGGGCAACAACGAGTTTGGGACTGTTGATCATGAGCGCCTC
TCTAAAATGCTTAGTCTTCCTGAAGAGCTTGCTCGAATGTACAGAGATGACATTACAATC
ATTGTAGTTCAGTTCAATTCTCATGTTGTAGGGGCGTATCAAAACCAAGAATAG
Protein Properties
Number of Residues 537
Molecular Weight 63694.735
Theoretical pI 6.822
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
MPAPTQLFFPLIRNCELSRIYGTACYCHHKHLCCSSSYIPQSRLRYTPHPAYATFCRPKE
NWWQYTQGRRYASTPQKFYLTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNQLPAN
APIEDRRSAATCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENAV
ESGRALLPILQWHKHPNDYFSKEASKLYFNSLRTYWQELIDLNTGESTDIDVKEALINAF
KRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANTGDSRAMLGVQE
EDGSWSAVTLSNDHNAQNERELERLKLEHPKSEAKSVVKQDRLLGLLMPFRAFGDVKFKW
SIDLQKRVIESGPDQLNDNEYTKFIPPNYHTPPYLTAEPEVTYHRLRPQDKFLVLATDGL
WETMHRQDVVRIVGEYLTGMHHQQPIAVGGYKVTLGQMHGLLTERRTKMSSVFEDQNAAT
HLIRHAVGNNEFGTVDHERLSKMLSLPEELARMYRDDITIIVVQFNSHVVGAYQNQE
GenBank ID Protein 239985428
UniProtKB/Swiss-Prot ID Q9P0J1
UniProtKB/Swiss-Prot Entry Name PDP1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001161781.1
GeneCard ID PDP1
GenAtlas ID PDP1
HGNC ID HGNC:9279
References
General References
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